ES8201980A1 - Un procedimiento para la preparacion de nuevos derivados de hidantoina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de hidantoina

Info

Publication number
ES8201980A1
ES8201980A1 ES499432A ES499432A ES8201980A1 ES 8201980 A1 ES8201980 A1 ES 8201980A1 ES 499432 A ES499432 A ES 499432A ES 499432 A ES499432 A ES 499432A ES 8201980 A1 ES8201980 A1 ES 8201980A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
hereinbefore defined
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499432A
Other languages
English (en)
Other versions
ES499432A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8201980A1 publication Critical patent/ES8201980A1/es
Publication of ES499432A0 publication Critical patent/ES499432A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IDANTOINA DE FORMULA (I), DONDE N ES UN NUMERO ENTERO DE 0 A 5; X ES -CO-,-CS-O-CH2-; Y ES -CH2-CH2-; R2 ES HIDROGENO O ALQUILO; R3 ES ALQUILO C1-9 O CICLOALQUILO C5-8; R4 ES ALQUILO C1-6, Y SUS SALES FARMACEUTICAS ACEPTABLES. CONSISTE EN HACER REACCIONAR EL GRUPO -CN DEL COMPUESTO DE FORMULA (II), DONDE R11 ES HIDROXI O HIDROXI PROTEGIDO, Y X, Y, R2, R3 Y N TIENEN LOS SIGNIFICADOS YA INDICADOS, CON UN REACTIVO NUCLEOFILO, Y POSTERIORMENTE, SI SE DESEA, CONVERTIR UN GRUPO X, Y O R4 EN OTRO GRUPO DIFERENTE X, Y O R4, O DESPROTEGER EL GRUPO R11 PROTEGIDO. LAS SALES FARMACEUTICAMENTE ACEPTABLES SE PREPARAN TRATANDO LOS COMPUESTOS DE FORMULA (I) CON UNA BASE O UN ACIDO ADECUADOS. DE APLICACION EN FARMACIA POR SU ACTIVIDAD ANTIULCERANTE, ANTIHIPERTENSORA Y BRONCODILATADORA.
ES499432A 1979-05-23 1981-02-13 Un procedimiento para la preparacion de nuevos derivados de hidantoina Granted ES499432A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7917931 1979-05-23

Publications (2)

Publication Number Publication Date
ES8201980A1 true ES8201980A1 (es) 1982-01-01
ES499432A0 ES499432A0 (es) 1982-01-01

Family

ID=10505375

Family Applications (3)

Application Number Title Priority Date Filing Date
ES491761A Expired ES8105302A1 (es) 1979-05-23 1980-05-22 Un procedimiento para la preparacion de nuevos derivados de hidantoina.
ES499433A Expired ES8201981A1 (es) 1979-05-23 1981-02-13 Un procedimiento para la preparacion de nuevos derivados de hidantoina
ES499432A Granted ES499432A0 (es) 1979-05-23 1981-02-13 Un procedimiento para la preparacion de nuevos derivados de hidantoina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES491761A Expired ES8105302A1 (es) 1979-05-23 1980-05-22 Un procedimiento para la preparacion de nuevos derivados de hidantoina.
ES499433A Expired ES8201981A1 (es) 1979-05-23 1981-02-13 Un procedimiento para la preparacion de nuevos derivados de hidantoina

Country Status (8)

Country Link
US (1) US4315022A (es)
EP (1) EP0020039A1 (es)
JP (1) JPS55162776A (es)
AU (1) AU5862380A (es)
DK (1) DK220680A (es)
ES (3) ES8105302A1 (es)
IL (1) IL60040A0 (es)
ZA (1) ZA802765B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496577A (en) * 1983-10-05 1985-01-29 Syntex (U.S.A.) Inc. Imidazolidinone prostaglandins, compositions and use
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
US6300503B1 (en) * 1999-12-17 2001-10-09 Dixie Chemical Company Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same
ES2327251T3 (es) * 2004-07-02 2009-10-27 Allergan, Inc. Analogos de prostaglandina.
CA2571786A1 (en) * 2004-07-02 2006-02-09 Allergan, Inc. Prostaglandin analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1143583B (it) * 1976-06-03 1986-10-22 Wellcome Found Derivati della idantoina e relativo procedimento di produzione
US4147796A (en) * 1976-12-18 1979-04-03 Beecham Group Limited 1-(3-Hydroxyalk-1-yl)-5-(carboxyalkyl)hydantoin derivatives
AU4778279A (en) * 1978-06-15 1979-12-20 Beecham Group Limited Prostaglandin analogues

Also Published As

Publication number Publication date
IL60040A0 (en) 1980-07-31
ES491761A0 (es) 1981-06-01
AU5862380A (en) 1980-11-27
ZA802765B (en) 1981-05-27
DK220680A (da) 1980-11-24
ES8105302A1 (es) 1981-06-01
ES499433A0 (es) 1982-01-01
JPS55162776A (en) 1980-12-18
ES499432A0 (es) 1982-01-01
US4315022A (en) 1982-02-09
ES8201981A1 (es) 1982-01-01
EP0020039A1 (en) 1980-12-10

Similar Documents

Publication Publication Date Title
ES8107157A1 (es) Procedimiento para la preparacion de 2-cloro-6-nitroanilinas
ES8202334A1 (es) Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina
ES8100261A1 (es) Un procedimiento para la preparacion de un indol
ES482134A1 (es) Un procedimiento para preparar derivados de 1-(3-mercapto- 2-metilpropanoil)-prolil-aminoacido.
DK149785D0 (da) Optisk aktive ketaler, fremgangsmaade til fremstilling heraf og deresanvendelse ved fremstillingen af alpha-arylalkansyrer
DE3069408D1 (en) 5-oxo- and 5-thioxoproline derivatives, process for their production and pharmaceutical compositions containing them
IL75583A0 (en) Pyrazole analogs of mevalonolactone and derivatives thereof,their preparation and pharmaceutical compositions containing them
ES8301881A1 (es) Un procedimiento para la preparacion de derivados de ariletanolamina que tienen actividad antiobesidad yno hploglicemi- ca.
IL62110A (en) Pharmaceutical compositions containing(substituted)phenyl alkyl imidazole derivatives,some new such compounds and their preparation
ES435458A1 (es) Un procedimiento para la preparacion de sales metalicas de beta-alaninas n, n-disustituidas.
ES483289A1 (es) Un procedimiento para la preparacion de 1,2,3,5, tetrahidro-himidazotienopirimidin-2-onas.
ES8201980A1 (es) Un procedimiento para la preparacion de nuevos derivados de hidantoina
ES479707A1 (es) Procedimiento de preparacion de nuevas 1,3-diaril-2-imino- imidazolinas y 2-imino-hexahidro-piridinas sustituidas.
IE780182L (en) N-9,10-DIHYDROLYSERGYL-m-AMINOBENZOIC ACID AMIDES.
ES8200669A1 (es) Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos
ES8103056A1 (es) Un procedimiento para la preparacion de derivados de hidan- toina
ES449765A1 (es) Procedimiento para la preparacion de nuevas homoftalimidas.
ES483253A1 (es) Un procedimiento para la prepracion de derivados de pipera- zin-2,5-diona.
ES8603844A1 (es) Procedimiento para la obtencion de esteres de acido fenoxialcancarboxilico sustituidos
ES464150A1 (es) Procedimiento para la preparacion de compuestos derivados defenil-amino-2-imidazolina
ES8304973A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiocarbapenem 3-sustituidos.
ES8308860A1 (es) "un procedimiento para la preparacion de pirimid-2-onas".
ES485492A1 (es) Un procedimiento para preparar derivados de triazol
ES8104242A1 (es) Un procedimiento para la preparacion de nuevos derivados de hidantoina.
ES452591A1 (es) Procedimiento para preparar esteres organicos de acidos fos-foricos.