ES8202013A1 - Un procedimiento para la preparacion de nuevos derivados delacido clavulanico. - Google Patents
Un procedimiento para la preparacion de nuevos derivados delacido clavulanico.Info
- Publication number
- ES8202013A1 ES8202013A1 ES496266A ES496266A ES8202013A1 ES 8202013 A1 ES8202013 A1 ES 8202013A1 ES 496266 A ES496266 A ES 496266A ES 496266 A ES496266 A ES 496266A ES 8202013 A1 ES8202013 A1 ES 8202013A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- preparation
- group
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical class OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO CLAVULANICO, ASI COMO DE SUS SALES Y ESTERES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 SON HIDROGENO O ALQUILO C1-6, Y A ES OXIGENO, AZUFRE O EL GRUPO NR3, DONDE R3 PUEDE SER UNO O VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1, R2 Y A TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN COMPUESTO DE FORMULA (III), EN LA QUE B PUEDE SER UNO DE VARIOS TIPOS DE RADICALES, O CON UN ESTER O UNA SAL DE MISMO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE APROTICO, A UNA TEMPERATURA ENTRE -50 50 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIANOS Y COMO INHIBIDORES DE B-LACTAMASA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7937261 | 1979-10-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES496266A0 ES496266A0 (es) | 1982-01-16 |
| ES8202013A1 true ES8202013A1 (es) | 1982-01-16 |
Family
ID=10508806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES496266A Expired ES8202013A1 (es) | 1979-10-26 | 1980-10-24 | Un procedimiento para la preparacion de nuevos derivados delacido clavulanico. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0028083B1 (es) |
| JP (1) | JPS5677283A (es) |
| AU (1) | AU6368480A (es) |
| CA (1) | CA1132548A (es) |
| DE (1) | DE3066511D1 (es) |
| DK (1) | DK452880A (es) |
| ES (1) | ES8202013A1 (es) |
| ZA (1) | ZA806375B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011032192A1 (de) | 2009-09-15 | 2011-03-24 | Nabriva Therapeutics Ag | Substituierte clavulansäure |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU503489B2 (en) * | 1975-10-13 | 1979-09-06 | Beecham Group Limited | Substituted aminodeoxy clavulanic acid |
| GB1585124A (en) * | 1976-06-04 | 1981-02-25 | Glaxo Lab Ltd | Clavulanic acid derivatives |
| GB2007667B (en) * | 1977-10-28 | 1982-05-12 | Beecham Group Ltd | Process for the preparation of ss-lactam compounds |
| EP0008877B1 (en) * | 1978-09-09 | 1983-10-26 | Beecham Group Plc | Derivatives of clavulanic acid, a process for their preparation and their use |
-
1980
- 1980-10-09 DE DE8080303552T patent/DE3066511D1/de not_active Expired
- 1980-10-09 EP EP80303552A patent/EP0028083B1/en not_active Expired
- 1980-10-16 ZA ZA00806375A patent/ZA806375B/xx unknown
- 1980-10-20 CA CA362,824A patent/CA1132548A/en not_active Expired
- 1980-10-24 ES ES496266A patent/ES8202013A1/es not_active Expired
- 1980-10-24 DK DK452880A patent/DK452880A/da unknown
- 1980-10-24 AU AU63684/80A patent/AU6368480A/en not_active Abandoned
- 1980-10-25 JP JP15002080A patent/JPS5677283A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0028083B1 (en) | 1984-02-08 |
| JPS5677283A (en) | 1981-06-25 |
| CA1132548A (en) | 1982-09-28 |
| DK452880A (da) | 1981-04-27 |
| ES496266A0 (es) | 1982-01-16 |
| AU6368480A (en) | 1981-04-30 |
| EP0028083A1 (en) | 1981-05-06 |
| ZA806375B (en) | 1981-10-28 |
| DE3066511D1 (en) | 1984-03-15 |
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