ES8202559A1 - Un procedimiento para la preparacion de un derivado del aci-do cefalosporanico - Google Patents
Un procedimiento para la preparacion de un derivado del aci-do cefalosporanicoInfo
- Publication number
- ES8202559A1 ES8202559A1 ES499081A ES499081A ES8202559A1 ES 8202559 A1 ES8202559 A1 ES 8202559A1 ES 499081 A ES499081 A ES 499081A ES 499081 A ES499081 A ES 499081A ES 8202559 A1 ES8202559 A1 ES 8202559A1
- Authority
- ES
- Spain
- Prior art keywords
- oral administration
- derivatives suitable
- cephalosporin derivatives
- aminothiazol
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000005042 acyloxymethyl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- -1 cephalosporin compound Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN DERIVADO DEL ACIDO CEFALOSPORANICO Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R1 ES UN RADICAL ALQUILO C1-7; Y R2 ES HIDROGENO O RADICAL METILO. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1 TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) T X ES UN ATOMO DE HALOGENO, CON UN AGENTE NITROSANTE A TEMPERATURA AMBIENTE O INFERIOR, SEGUIDA DE LA REACCION DEL PRODUCTO OBTENIDO CON TIOUREA, EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE Y A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN ALICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6829179A JPS55160782A (en) | 1979-06-01 | 1979-06-01 | Cephalosporin compound for oral administration |
| JP8421979A JPS568391A (en) | 1979-07-03 | 1979-07-03 | Cephalosporin compound for oral use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES499081A0 ES499081A0 (es) | 1982-02-01 |
| ES8202559A1 true ES8202559A1 (es) | 1982-02-01 |
Family
ID=26409507
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES492045A Granted ES492045A0 (es) | 1979-06-01 | 1980-05-30 | Un procedimiento para la preparacion de un derivado del aci-do cefalosporanico |
| ES499081A Expired ES8202559A1 (es) | 1979-06-01 | 1981-02-03 | Un procedimiento para la preparacion de un derivado del aci-do cefalosporanico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES492045A Granted ES492045A0 (es) | 1979-06-01 | 1980-05-30 | Un procedimiento para la preparacion de un derivado del aci-do cefalosporanico |
Country Status (6)
| Country | Link |
|---|---|
| DE (1) | DE3020625A1 (es) |
| ES (2) | ES492045A0 (es) |
| FR (1) | FR2457870A1 (es) |
| GB (1) | GB2051066A (es) |
| IT (1) | IT8067851A0 (es) |
| NL (1) | NL8003186A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK379681A (da) * | 1981-07-17 | 1983-01-18 | Hoffmann La Roche | Fremgangsmaade til fremstilling af cephalosporiderivater |
| EP0148007A3 (en) * | 1983-12-26 | 1986-04-02 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds and medicaments and their production |
| US4914091A (en) * | 1984-04-02 | 1990-04-03 | American Cyanamid Company | Esters of cephalosporin derivitives |
| US4935508A (en) * | 1988-08-23 | 1990-06-19 | Bristol-Myers Company | Process for cephem prodrug esters |
-
1980
- 1980-05-30 NL NL8003186A patent/NL8003186A/nl not_active Application Discontinuation
- 1980-05-30 GB GB8017766A patent/GB2051066A/en not_active Withdrawn
- 1980-05-30 DE DE19803020625 patent/DE3020625A1/de not_active Withdrawn
- 1980-05-30 ES ES492045A patent/ES492045A0/es active Granted
- 1980-05-30 IT IT8067851A patent/IT8067851A0/it unknown
- 1980-06-02 FR FR8012193A patent/FR2457870A1/fr not_active Withdrawn
-
1981
- 1981-02-03 ES ES499081A patent/ES8202559A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8105326A1 (es) | 1981-05-16 |
| ES499081A0 (es) | 1982-02-01 |
| ES492045A0 (es) | 1981-05-16 |
| IT8067851A0 (it) | 1980-05-30 |
| GB2051066A (en) | 1981-01-14 |
| DE3020625A1 (de) | 1980-12-04 |
| NL8003186A (nl) | 1980-12-03 |
| FR2457870A1 (fr) | 1980-12-26 |
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