ES8202802A1 - Procedimiento para la preparacion de nuevos derivados de acido 2-amino-benzoico - Google Patents

Procedimiento para la preparacion de nuevos derivados de acido 2-amino-benzoico

Info

Publication number
ES8202802A1
ES8202802A1 ES501882A ES501882A ES8202802A1 ES 8202802 A1 ES8202802 A1 ES 8202802A1 ES 501882 A ES501882 A ES 501882A ES 501882 A ES501882 A ES 501882A ES 8202802 A1 ES8202802 A1 ES 8202802A1
Authority
ES
Spain
Prior art keywords
amino
benzoic
medicines
intermediates
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501882A
Other languages
English (en)
Other versions
ES501882A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803016650 external-priority patent/DE3016650A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES501882A0 publication Critical patent/ES501882A0/es
Publication of ES8202802A1 publication Critical patent/ES8202802A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DEL ACIDO 1-AMINO-BENZOICO. CONSISTE EN REDUCIR UN COMPUESTO NITRADO DE FORMULA GENERAL (I). OPCIONALMENTE EL COMPUESTO OBTENIDO (II) SE TRANSFORMA MEDIANTE HIDROLISIS EN OTRO COMPUESTO EN QUE W ES UN GRUPO CARBOXI, O BIEN TRANSFORMA EN SUS SALES DE ADICION DE ACIDO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 50C. LA REDUCCION SE LLEVA A CABO CON HIDROGENO ACTIVADO CATALITICAMENTE, CON HIDRAZINA EN PRESENCIA DE NIQUEL RANY, CON HIDROGENO NACIENTE O CON UNA SAL METALICA.
ES501882A 1980-04-30 1981-05-05 Procedimiento para la preparacion de nuevos derivados de acido 2-amino-benzoico Expired ES8202802A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803016650 DE3016650A1 (de) 1979-07-13 1980-04-30 Neue 2-amino-benzoesaeure-derivate, deren herstellung und deren verwendung als arzneimittel oder zwischenprodukte

Publications (2)

Publication Number Publication Date
ES501882A0 ES501882A0 (es) 1982-03-01
ES8202802A1 true ES8202802A1 (es) 1982-03-01

Family

ID=6101342

Family Applications (3)

Application Number Title Priority Date Filing Date
ES501884A Granted ES501884A0 (es) 1980-04-30 1981-05-05 Procedimiento para la preparacion de nuevos derivados de acido 2-amino-benzoico
ES501882A Expired ES8202802A1 (es) 1980-04-30 1981-05-05 Procedimiento para la preparacion de nuevos derivados de acido 2-amino-benzoico
ES501883A Granted ES501883A0 (es) 1980-04-30 1981-05-05 Procedimiento para la preparacion de nuevos derivados de acido 2-amino-benzoico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES501884A Granted ES501884A0 (es) 1980-04-30 1981-05-05 Procedimiento para la preparacion de nuevos derivados de acido 2-amino-benzoico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES501883A Granted ES501883A0 (es) 1980-04-30 1981-05-05 Procedimiento para la preparacion de nuevos derivados de acido 2-amino-benzoico

Country Status (5)

Country Link
EP (1) EP0063826B1 (es)
DE (1) DE3069781D1 (es)
ES (3) ES501884A0 (es)
HU (1) HU186675B (es)
NO (1) NO843735L (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9326373D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
GB9326232D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3936467A (en) * 1968-03-27 1976-02-03 Ciba-Geigy Corporation Hydroxyalkylenimino-phenyl-acetic acids

Also Published As

Publication number Publication date
EP0063826B1 (de) 1984-12-05
ES8202803A1 (es) 1982-03-01
ES8202804A1 (es) 1982-03-01
NO843735L (no) 1981-01-14
ES501884A0 (es) 1982-03-01
EP0063826A2 (de) 1982-11-03
HU186675B (en) 1985-09-30
ES501883A0 (es) 1982-03-01
ES501882A0 (es) 1982-03-01
EP0063826A3 (en) 1982-12-29
DE3069781D1 (en) 1985-01-17

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