ES8202834A1 - Un procedimiento para la preparacion de un adyuvante immuno-logico. - Google Patents

Un procedimiento para la preparacion de un adyuvante immuno-logico.

Info

Publication number
ES8202834A1
ES8202834A1 ES496276A ES496276A ES8202834A1 ES 8202834 A1 ES8202834 A1 ES 8202834A1 ES 496276 A ES496276 A ES 496276A ES 496276 A ES496276 A ES 496276A ES 8202834 A1 ES8202834 A1 ES 8202834A1
Authority
ES
Spain
Prior art keywords
reacted
preparation
compositions
colesten
iloxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496276A
Other languages
English (en)
Other versions
ES496276A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8202834A1 publication Critical patent/ES8202834A1/es
Publication of ES496276A0 publication Critical patent/ES496276A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN ADYUVANTE INMUNOLOGICO. CONSISTENTE EN SOMETER A REACCION DE ACETILACION LA 6-DESOXI-6-FTALIMIDO-D-GALACTOPIRANOSA, HACIENDOSE REACCIONAR EL PRODUCTO OBTANIDO CON ACIDO BROMHIDRICO, Y EL BROMURO OBTENIDO CON TIOUREA. SEGUIDAMENTE SE HACE REACCIONAR EL PRODUCTO FORMADO CON METABISULFITO DE POTASIO Y EL OBTENIDO EN ESTA ETAPA SE HACE REACCIONAR CON YODURO DE 6-(5-COLESTEN-3B-ILOXI) HEXILO, SOMETIENDOSE EL RESULTANTE A UNA REACCION DE HIDROLISIS PARA OBTENER FINALMENTE EL ADYUVANTE 6-(5-COLESTEN-3B-ILOXI) HEXIL 6-AMINO-6-DESOXI-1-TIO-B-D-GALACTOPIRANOSIDO. SI SE DESEA PUEDE HACERSE REACCIONAR ESTE COMPUESTO CON EL ACIDO OLEICO PARA PREPARAR EL CORRESPONDIENTE 6-OLEAMIDO-COMPUESTO.
ES496276A 1979-10-26 1980-10-24 Un procedimiento para la preparacion de un adyuvante immuno-logico. Granted ES496276A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/088,692 US4301152A (en) 1979-10-26 1979-10-26 Immunologic adjuvant

Publications (2)

Publication Number Publication Date
ES8202834A1 true ES8202834A1 (es) 1982-02-16
ES496276A0 ES496276A0 (es) 1982-02-16

Family

ID=22212874

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496276A Granted ES496276A0 (es) 1979-10-26 1980-10-24 Un procedimiento para la preparacion de un adyuvante immuno-logico.

Country Status (8)

Country Link
US (1) US4301152A (es)
EP (1) EP0028196B1 (es)
JP (1) JPS57114599A (es)
DE (1) DE3068451D1 (es)
DK (1) DK449580A (es)
ES (1) ES496276A0 (es)
GR (1) GR71208B (es)
PT (1) PT71959B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612370A (en) * 1982-04-02 1986-09-16 The Regents Of The University Of California Lipid-saccharide reaction products
US4652553A (en) * 1985-11-25 1987-03-24 Merck & Co., Inc. Steroidal glycolipids as host resistance stimulators
US4652637A (en) * 1985-11-25 1987-03-24 Merck & Co., Inc. Steroidal glycolipids
US4970199A (en) * 1987-06-18 1990-11-13 Merck & Co., Inc. Steroidal glycolipids as host resistance stimulators against viral infection
US4942154A (en) * 1987-06-18 1990-07-17 Merck & Co., Inc. Steroidal glycolipids as host resistance stimulators against viral infection
US5019568A (en) * 1987-06-18 1991-05-28 Merck & Co., Inc. Steroidal glycolipids as host resistance stimulators against viral infection
US5055562A (en) * 1988-02-01 1991-10-08 Biomira, Inc. Fluorocarbon chain-containing antigenic conjugates
US5514784A (en) * 1993-03-19 1996-05-07 Wong; Chi-Huey Thio linked glycosyl compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2216617A (en) * 1938-08-31 1940-10-01 Katz Jacob Surface active anionic compounds of amino alcohols
US4131732A (en) * 1977-04-21 1978-12-26 Smithkline Corporation Method for preparing auranofin
US4189471A (en) * 1978-07-11 1980-02-19 Merck & Co., Inc. Immunologic glycolipid adjuvants

Also Published As

Publication number Publication date
US4301152A (en) 1981-11-17
EP0028196A2 (en) 1981-05-06
DE3068451D1 (en) 1984-08-09
GR71208B (es) 1983-04-11
EP0028196A3 (en) 1981-10-14
JPS57114599A (en) 1982-07-16
PT71959B (en) 1982-03-31
EP0028196B1 (en) 1984-07-04
ES496276A0 (es) 1982-02-16
DK449580A (da) 1981-04-27
PT71959A (en) 1980-11-01

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