ES8207120A1 - Un procedimiento para la preparacion de nuevos derivados transisomericos de 4-fenil-1,2,3,4-tetrahidro-1-naftalenami-na. - Google Patents

Un procedimiento para la preparacion de nuevos derivados transisomericos de 4-fenil-1,2,3,4-tetrahidro-1-naftalenami-na.

Info

Publication number
ES8207120A1
ES8207120A1 ES506893A ES506893A ES8207120A1 ES 8207120 A1 ES8207120 A1 ES 8207120A1 ES 506893 A ES506893 A ES 506893A ES 506893 A ES506893 A ES 506893A ES 8207120 A1 ES8207120 A1 ES 8207120A1
Authority
ES
Spain
Prior art keywords
trans
isomeric
tetrahydro
phenyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506893A
Other languages
English (en)
Other versions
ES506893A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26782055&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8207120(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8207120A1 publication Critical patent/ES8207120A1/es
Publication of ES506893A0 publication Critical patent/ES506893A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS TRANS-ISOMERICOS DE 4-FENIL-1, 2 3,4-TETRAHIDRO-1-NAFTALENAMINA. CONSTA DE LAS SIGUIENTES ETAPAS: 1. SOMETER A HIDROGENACION A UN COMPUESTO DE FORMULA GENERAL (I) PARA OBTENER UNA MEZCLA DE BASE CIS- Y TRANS-ISOMERICAS DE FORMULA (II). 2. SEPARAR UNA BSE TRANS-ISOMERICA DE FORMULA (II) DE LA MEZCLA RESULTANTE DE LA PRIMERA ETAPA. 3. OPCIONALMENTE CONVERTIR LA BASE TRANS-ISOMERICA RESULTANTE DE LA SEGUNDA ETAPA EN UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE. R1 ES HIDROGENO O SU ALQUILO DE 1 A 3 ATOMOS DE CARBONO; R2 ES ALQUILO DE 1 A 3 ATOMOS DE CARBONO.
ES506893A 1979-11-01 1981-11-05 Un procedimiento para la preparacion de nuevos derivados transisomericos de 4-fenil-1,2,3,4-tetrahidro-1-naftalenami-na. Granted ES506893A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9023779A 1979-11-01 1979-11-01
US06/184,447 US4556676A (en) 1979-11-01 1980-09-05 Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine

Publications (2)

Publication Number Publication Date
ES8207120A1 true ES8207120A1 (es) 1982-09-01
ES506893A0 ES506893A0 (es) 1982-09-01

Family

ID=26782055

Family Applications (2)

Application Number Title Priority Date Filing Date
ES496441A Granted ES496441A0 (es) 1979-11-01 1980-10-31 Un procedimiento para la preparacion de nuevos derivados transisomericos de 4-fenil-1,2,3,4- tetrahidro-1-naftalenamina.
ES506893A Granted ES506893A0 (es) 1979-11-01 1981-11-05 Un procedimiento para la preparacion de nuevos derivados transisomericos de 4-fenil-1,2,3,4-tetrahidro-1-naftalenami-na.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES496441A Granted ES496441A0 (es) 1979-11-01 1980-10-31 Un procedimiento para la preparacion de nuevos derivados transisomericos de 4-fenil-1,2,3,4- tetrahidro-1-naftalenamina.

Country Status (18)

Country Link
US (1) US4556676A (es)
EP (1) EP0028901B1 (es)
KR (1) KR840002021B1 (es)
AR (2) AR225196A1 (es)
AT (1) ATE2667T1 (es)
AU (1) AU517842B2 (es)
CA (1) CA1130816A (es)
DE (1) DE3062226D1 (es)
DK (1) DK149308C (es)
ES (2) ES496441A0 (es)
FI (1) FI68807C (es)
GR (1) GR70782B (es)
IE (1) IE50396B1 (es)
IL (1) IL61376A (es)
NO (1) NO149102C (es)
PH (1) PH15468A (es)
PT (1) PT72005B (es)
YU (2) YU41744B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
US4866208A (en) * 1981-12-21 1989-09-12 The Dow Chemical Company Meta-phenylene diamine derivatives
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
US4839104A (en) * 1987-06-11 1989-06-13 Pfizer, Inc. Process for preparing sertraline intermediates
FR2623802B1 (fr) * 1987-11-26 1990-05-04 Lucien Laboratoires Derives d'amino-4 trifluoromethyl-1 tetralines. leur preparation et leur application en therapeutique
FR2642065B1 (fr) * 1989-01-24 1991-05-24 Lipha Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
FR2665443B1 (fr) * 1990-08-03 1992-11-06 Lucien Laboratoires Derives d'amino-4-methyl-1-tetralines, leur preparation et leur application en therapeutique.
US5082970A (en) * 1991-03-06 1992-01-21 Pfizer Inc. Process for recycling amine isomer
GB9114948D0 (en) * 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US5196607A (en) * 1992-02-14 1993-03-23 Pfizer Inc. Process for preparing ketone enantiomer
US5248699A (en) * 1992-08-13 1993-09-28 Pfizer Inc. Sertraline polymorph
US5466880A (en) * 1992-09-15 1995-11-14 Pfizer Inc. Process for preparing ketone enantiomer
EP0697894A4 (en) * 1993-03-31 1996-05-01 Univ Pennsylvania DOPAMINE D-3 AND SEROTONIN (5-HT 1A) RECEPTOR LIGANDS AND IMAGING AGENTS
EP0724552B1 (en) * 1993-11-30 1997-10-29 Pfizer Inc. Process for preparing a chiral tetralone
US6410794B1 (en) 1994-12-16 2002-06-25 Uop Llc Process for preparation of pharmaceutically desired chiral tetralone from tetralones
US6455736B1 (en) 1994-12-16 2002-09-24 Uop Llc Process for preparation of pharmaceutically desired sertraline and sertraline analogs
HU222341B1 (hu) * 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
IN182588B (es) 1998-05-12 1999-05-08 Sun Pharmaceutical Ind Ltd
IN187170B (es) 2000-01-04 2002-02-23 Sun Pharmaceutical Ind Ltd
DE10006411C2 (de) * 2000-02-14 2002-03-07 Huf Huelsbeck & Fuerst Gmbh Elektronischer Zündanlaßschalter für Kraftfahrzeuge und Reserveschlüssel zur Betätigung desselben
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
US6482440B2 (en) 2000-09-21 2002-11-19 Phase 2 Discovery, Inc. Long acting antidepressant microparticles
US6723878B2 (en) 2001-06-15 2004-04-20 Orion Corporation Fermion Method for preparing sertraline
EP1542961B1 (en) * 2002-09-16 2013-09-11 Sepracor, Inc. Trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine for use in treatment of cns disorders
CN100584818C (zh) * 2002-09-16 2010-01-27 塞普拉科公司 用反式4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺及其甲酰胺治疗cns病症
JP2006504693A (ja) * 2002-09-16 2006-02-09 セプラコア インコーポレーテッド トランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミンによるｃｎｓ障害の治療
US8134029B2 (en) 2002-09-16 2012-03-13 Sunovion Pharmaceuticals Inc. Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10334187A1 (de) * 2003-07-26 2005-03-03 Schwarz Pharma Ag Substituierte 2-Aminotetraline zur Behandlung von Depressionen
US20060014838A1 (en) * 2004-07-14 2006-01-19 Sudhakar Valluri Process for converting trans-sertraline to cis-sertraline
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
DK2816024T3 (en) 2006-03-31 2017-10-30 Sunovion Pharmaceuticals Inc CHIRALE AMINER
AU2007254751A1 (en) * 2006-05-31 2007-12-13 Sepracor Inc. Treatment of pain disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine and its formamide
WO2007146796A2 (en) * 2006-06-13 2007-12-21 Ramot At Tel-Aviv University Ltd. Antiproliferative compounds, compositions and methods of use
EP1987815A1 (en) * 2007-05-04 2008-11-05 Schwarz Pharma Ag Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
US20100081713A1 (en) * 2008-03-19 2010-04-01 CombinatoRx, (Singapore) Pte. Ltd. Compositions and methods for treating viral infections
MX2016014768A (es) * 2014-05-13 2017-03-06 Sunovion Pharmaceuticals Inc Dosificacion de dasotralina y metodo para el tratamiento del trastorno por deficit de atencion con hiperactividad adhd.
US20170266133A1 (en) * 2014-05-13 2017-09-21 Sunovion Pharmaceuticals Inc. Methods and compositions of dasotraline for treatment of adhd
WO2016046669A2 (en) * 2014-09-27 2016-03-31 Mohan M Alapati Compositions and methods for the treatment of depression and neurological diseases

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
GB793853A (en) * 1954-09-15 1958-04-23 Schering Ag Manufacture of new 3-amino-indanes
DE1098511B (de) * 1959-11-21 1961-02-02 Schering Ag Verfahren zur Abtrennung von analgetisch wirksamen d-1-Phenyl-3-dimethylaminoindan
US3704323A (en) * 1969-12-23 1972-11-28 Squibb & Sons Inc Indane derivatives
GB1420472A (en) * 1972-09-27 1976-01-07 Pfizer Aminophenyltetralin compounds
US4045488A (en) * 1974-11-06 1977-08-30 Pfizer Inc. Aminophenyltetralin compounds
US4029731A (en) * 1974-11-06 1977-06-14 Pfizer Inc. Aminophenyltetralin compounds

Also Published As

Publication number Publication date
GR70782B (es) 1983-03-23
KR830004201A (ko) 1983-07-06
DK149308C (da) 1986-12-08
DE3062226D1 (en) 1983-04-07
IL61376A0 (en) 1980-12-31
IE802260L (en) 1981-05-01
YU277480A (en) 1983-09-30
AR229106A1 (es) 1983-06-15
AR225196A1 (es) 1982-02-26
NO149102B (no) 1983-11-07
YU3383A (en) 1983-09-30
YU42066B (en) 1988-04-30
FI803399L (fi) 1981-05-02
YU41744B (en) 1987-12-31
PH15468A (en) 1983-01-24
ES8201948A1 (es) 1982-01-16
PT72005B (en) 1981-08-31
US4556676A (en) 1985-12-03
PT72005A (en) 1980-11-01
DK149308B (da) 1986-04-28
IL61376A (en) 1983-10-31
ES496441A0 (es) 1982-01-16
ES506893A0 (es) 1982-09-01
FI68807C (fi) 1985-11-11
ATE2667T1 (de) 1983-03-15
DK462480A (da) 1981-05-02
IE50396B1 (en) 1986-04-16
CA1130816A (en) 1982-08-31
NO149102C (no) 1984-02-15
NO803259L (no) 1981-05-04
KR840002021B1 (ko) 1984-11-05
AU6389880A (en) 1981-05-07
AU517842B2 (en) 1981-08-27
EP0028901B1 (en) 1983-03-02
FI68807B (fi) 1985-07-31
EP0028901A1 (en) 1981-05-20

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