ES8300732A1 - Procedure for the obtaining of derivados de furil mettil mercaptano and its salts of pharmacological interest (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of derivados de furil mettil mercaptano and its salts of pharmacological interest (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES8300732A1 ES8300732A1 ES502940A ES502940A ES8300732A1 ES 8300732 A1 ES8300732 A1 ES 8300732A1 ES 502940 A ES502940 A ES 502940A ES 502940 A ES502940 A ES 502940A ES 8300732 A1 ES8300732 A1 ES 8300732A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- salts
- procedure
- obtaining
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000144 pharmacologic effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- SXPUVBFQXJHYNS-UHFFFAOYSA-N α-furil Chemical compound C=1C=COC=1C(=O)C(=O)C1=CC=CO1 SXPUVBFQXJHYNS-UHFFFAOYSA-N 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 238000006683 Mannich reaction Methods 0.000 abstract 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 238000005902 aminomethylation reaction Methods 0.000 abstract 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the obtaining of derivatives of furilmetilmercaptano and of its salts of pharmacological interest of formula (I). It consists of the reaction of methyl mercaptan fury with chloroacetonitrilo or chloroacetamide in an inert solvent, such as dimethylformamide at temperature between 80ºc and 160ºc; following dimethyl amino methylation according to a mannich reaction, reduction of the cyan or amido group with lithium and aluminum hydride and reaction of the amine with N-methyl-1 (methylthyl) -nitroetenoamine. > these compounds have pharmacological applications for the treatment of the affections caused by a gastric hypersecretion. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES502940A ES8300732A1 (en) | 1981-06-10 | 1981-06-10 | Procedure for the obtaining of derivados de furil mettil mercaptano and its salts of pharmacological interest (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES502940A ES8300732A1 (en) | 1981-06-10 | 1981-06-10 | Procedure for the obtaining of derivados de furil mettil mercaptano and its salts of pharmacological interest (Machine-translation by Google Translate, not legally binding) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES502940A0 ES502940A0 (en) | 1982-11-01 |
| ES8300732A1 true ES8300732A1 (en) | 1982-11-01 |
Family
ID=8482518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES502940A Expired ES8300732A1 (en) | 1981-06-10 | 1981-06-10 | Procedure for the obtaining of derivados de furil mettil mercaptano and its salts of pharmacological interest (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8300732A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT387573B (en) * | 1984-05-02 | 1989-02-10 | Richter Gedeon Vegyeszet | METHOD FOR PRODUCING THE BASIC THIOAETHER 2 - ((2-AMINO-AETHYL) -THIOMETHYL) -5 (DIMETHYL-AMINOMETHYL) -FURANE AND THE ACID ADDITION SALTS THEREOF |
| AT389873B (en) * | 1983-07-15 | 1990-02-12 | Richter Gedeon Vegyeszet | METHOD FOR PRODUCING THE 1- (2- (5- / |
-
1981
- 1981-06-10 ES ES502940A patent/ES8300732A1/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT389873B (en) * | 1983-07-15 | 1990-02-12 | Richter Gedeon Vegyeszet | METHOD FOR PRODUCING THE 1- (2- (5- / |
| AT387573B (en) * | 1984-05-02 | 1989-02-10 | Richter Gedeon Vegyeszet | METHOD FOR PRODUCING THE BASIC THIOAETHER 2 - ((2-AMINO-AETHYL) -THIOMETHYL) -5 (DIMETHYL-AMINOMETHYL) -FURANE AND THE ACID ADDITION SALTS THEREOF |
Also Published As
| Publication number | Publication date |
|---|---|
| ES502940A0 (en) | 1982-11-01 |
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