ES8300747A1 - Procedimiento para la preparacion de derivados de acido in- dolacetico - Google Patents
Procedimiento para la preparacion de derivados de acido in- dolaceticoInfo
- Publication number
- ES8300747A1 ES8300747A1 ES502848A ES502848A ES8300747A1 ES 8300747 A1 ES8300747 A1 ES 8300747A1 ES 502848 A ES502848 A ES 502848A ES 502848 A ES502848 A ES 502848A ES 8300747 A1 ES8300747 A1 ES 8300747A1
- Authority
- ES
- Spain
- Prior art keywords
- same
- producing
- pharmaceutical compositions
- indol acetic
- acetic derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- BOIZHGCLUSQNLD-UHFFFAOYSA-N acetic acid;1h-indole Chemical class CC(O)=O.C1=CC=C2NC=CC2=C1 BOIZHGCLUSQNLD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO INDOLACETICO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X ES HIDROGENO, FLUOR, CLORO O ALCOHILO C <003> ; Y N VALE DE 0 A 3. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE X Y N SON LOS MISMOS QUE EN LA FORMULA (I), O UNA SAL ALCALINA DEL MISMO, CON ACIDO 1-(P-CLOROBENZOIL)-5-METOXI-2-METILINDOL-3-ACETICO, UN CLORURO O UN ALCOHILESTER C <003> DEL MISMO. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE EN PRESENCIA DE UNA CARBODIIMIDA Y DE TRIMETIALUMINIO. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITROMBOTICA, ANTIARTERIOSCLEROTICA, ANALGESICA Y ANTIFLOGISTICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3034005A DE3034005C2 (de) | 1980-09-10 | 1980-09-10 | Indolessigsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8300747A1 true ES8300747A1 (es) | 1982-11-01 |
| ES502848A0 ES502848A0 (es) | 1982-11-01 |
Family
ID=6111558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES502848A Granted ES502848A0 (es) | 1980-09-10 | 1981-06-08 | Procedimiento para la preparacion de derivados de acido in- dolacetico |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0047358B1 (es) |
| JP (1) | JPS5750988A (es) |
| AR (1) | AR229470A1 (es) |
| AT (1) | ATE9470T1 (es) |
| AU (1) | AU539442B2 (es) |
| CA (1) | CA1164862A (es) |
| DE (1) | DE3034005C2 (es) |
| DK (1) | DK236781A (es) |
| ES (1) | ES502848A0 (es) |
| FI (1) | FI68622C (es) |
| HU (1) | HU187338B (es) |
| IE (1) | IE51776B1 (es) |
| PT (1) | PT73435B (es) |
| YU (1) | YU135081A (es) |
| ZA (1) | ZA813637B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3236243A1 (de) * | 1982-09-30 | 1984-04-05 | Merck Patent Gmbh, 6100 Darmstadt | Schwefelhaltige indolderivate |
| DE60323130D1 (de) | 2002-11-25 | 2008-10-02 | Hoffmann La Roche | Indolderivaten |
| CN104876848B (zh) * | 2015-05-15 | 2017-05-17 | 南开大学 | 一种1‑酰基‑3‑吲哚硫酯化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD70880A (es) * | ||||
| US3966956A (en) * | 1972-07-14 | 1976-06-29 | Troponwerke Dinklage & Company | [1-(P-Chlorobenzoyl)-5-methoxy-2-methyl-3-indole]acetoxyacetic acid and salts in treating inflammation |
| US4119638A (en) * | 1976-11-29 | 1978-10-10 | G. D. Searle & Co. | Thio-ester of 1 (p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid |
| DE2735537A1 (de) * | 1977-08-06 | 1979-02-22 | Troponwerke Gmbh & Co Kg | Indolacetoxyacetylaminosaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1980
- 1980-09-10 DE DE3034005A patent/DE3034005C2/de not_active Expired
-
1981
- 1981-05-26 EP EP81104024A patent/EP0047358B1/en not_active Expired
- 1981-05-26 YU YU01350/81A patent/YU135081A/xx unknown
- 1981-05-26 AT AT81104024T patent/ATE9470T1/de not_active IP Right Cessation
- 1981-05-29 IE IE1209/81A patent/IE51776B1/en unknown
- 1981-05-29 CA CA000378654A patent/CA1164862A/en not_active Expired
- 1981-05-29 JP JP56081284A patent/JPS5750988A/ja active Pending
- 1981-05-29 DK DK236781A patent/DK236781A/da not_active Application Discontinuation
- 1981-05-29 ZA ZA00813637A patent/ZA813637B/xx unknown
- 1981-06-08 ES ES502848A patent/ES502848A0/es active Granted
- 1981-06-12 AR AR285704A patent/AR229470A1/es active
- 1981-07-08 AU AU72650/81A patent/AU539442B2/en not_active Ceased
- 1981-07-15 HU HU812076A patent/HU187338B/hu unknown
- 1981-07-27 PT PT73435A patent/PT73435B/pt unknown
- 1981-08-04 FI FI812418A patent/FI68622C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0047358B1 (en) | 1984-09-19 |
| DK236781A (da) | 1982-03-11 |
| YU135081A (en) | 1984-02-29 |
| FI812418L (fi) | 1982-03-11 |
| JPS5750988A (en) | 1982-03-25 |
| AU539442B2 (en) | 1984-09-27 |
| HU187338B (en) | 1985-12-28 |
| FI68622B (fi) | 1985-06-28 |
| AU7265081A (en) | 1982-03-18 |
| FI68622C (fi) | 1985-10-10 |
| CA1164862A (en) | 1984-04-03 |
| DE3034005A1 (de) | 1982-05-06 |
| ATE9470T1 (de) | 1984-10-15 |
| PT73435B (en) | 1982-10-08 |
| PT73435A (en) | 1981-08-01 |
| DE3034005C2 (de) | 1982-12-09 |
| EP0047358A1 (en) | 1982-03-17 |
| IE811209L (en) | 1982-03-10 |
| ZA813637B (en) | 1982-06-30 |
| IE51776B1 (en) | 1987-04-01 |
| AR229470A1 (es) | 1983-08-31 |
| ES502848A0 (es) | 1982-11-01 |
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