ES8301899A1 - Un procedimiento para la preparacion de n-carboxialquil-dipeptidos. - Google Patents

Un procedimiento para la preparacion de n-carboxialquil-dipeptidos.

Info

Publication number
ES8301899A1
ES8301899A1 ES506034A ES506034A ES8301899A1 ES 8301899 A1 ES8301899 A1 ES 8301899A1 ES 506034 A ES506034 A ES 506034A ES 506034 A ES506034 A ES 506034A ES 8301899 A1 ES8301899 A1 ES 8301899A1
Authority
ES
Spain
Prior art keywords
substituted
loweralkyl
chem
dipeptides
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506034A
Other languages
English (en)
Other versions
ES506034A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8301899A1 publication Critical patent/ES8301899A1/es
Publication of ES506034A0 publication Critical patent/ES506034A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE N-CARBOXIALQUIL-DIPEPTIDOS, DE FORMULA (I), EN LA QUE R Y R SON HIDROXI, ALCOXI INFERIOR O ARALOXI; R ES HIDROGENO O ALQUILO INFERIOR; R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 1-3. CONSISTE EN LA REACCION DE UNA CETONA DE FORMULA RCOCOR CON UN DIPEPTIDO O DIPEPTIDO PROTEGIDO, DE FORMULA (II), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO, EN DISOLUCION ACUOSA O EN UN DISOLVENTE ORGANICO, EN PRESENCIA DE UN AGENTE REDUCTOR. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INHIBIDORES DEL ENZIMA CONVERTIDOR DE LA ANGIOTENSINA Y ANTIHIPERTENSIVOS.
ES506034A 1980-10-06 1981-10-05 Un procedimiento para la preparacion de n-carboxialquil-dipeptidos. Granted ES506034A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19471580A 1980-10-06 1980-10-06
US29486481A 1981-08-25 1981-08-25

Publications (2)

Publication Number Publication Date
ES8301899A1 true ES8301899A1 (es) 1983-01-01
ES506034A0 ES506034A0 (es) 1983-01-01

Family

ID=26890323

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506034A Granted ES506034A0 (es) 1980-10-06 1981-10-05 Un procedimiento para la preparacion de n-carboxialquil-dipeptidos.

Country Status (5)

Country Link
EP (1) EP0049506A1 (es)
DK (1) DK440281A (es)
ES (1) ES506034A0 (es)
GR (1) GR75775B (es)
PT (1) PT73767B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
DE3378266D1 (en) * 1982-01-11 1988-11-24 Merck & Co Inc Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4483725A (en) * 1982-09-30 1984-11-20 At&T Bell Laboratories Reactive vapor deposition of multiconstituent material
US4652668A (en) * 1985-07-03 1987-03-24 Biomeasure, Inc. Aromatic amino acid derivatives
US5110799A (en) * 1989-07-28 1992-05-05 Merck & Co., Inc. Antiherpetic agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GR75775B (es) 1984-08-02
EP0049506A1 (en) 1982-04-14
PT73767B (en) 1983-10-14
PT73767A (en) 1981-11-01
DK440281A (da) 1982-04-07
ES506034A0 (es) 1983-01-01

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