ES8302460A1 - Procedimiento para preparar un complejo de antitrombina y de heparina de alta actividad. - Google Patents

Procedimiento para preparar un complejo de antitrombina y de heparina de alta actividad.

Info

Publication number
ES8302460A1
ES8302460A1 ES505911A ES505911A ES8302460A1 ES 8302460 A1 ES8302460 A1 ES 8302460A1 ES 505911 A ES505911 A ES 505911A ES 505911 A ES505911 A ES 505911A ES 8302460 A1 ES8302460 A1 ES 8302460A1
Authority
ES
Spain
Prior art keywords
antithrombin
heparin
complex
matrix
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505911A
Other languages
English (en)
Other versions
ES505911A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Cutter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cutter Laboratories Inc filed Critical Cutter Laboratories Inc
Publication of ES8302460A1 publication Critical patent/ES8302460A1/es
Publication of ES505911A0 publication Critical patent/ES505911A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN COMPLEJO DE ANTITROMBINA Y DE HEPARINA DE ALTA ACTIVIDAD. CONSTA DE LAS SIGUIENTES ETAPAS: 1<002> PONER EN CONTACTO UNA MATRIZ INSOLUBLE EN AGUA CONTENIENDO LECTINA CON HEPARINA Y ANTITROMBINA, CON LO QUE SE OBTIENE UNA MATRIZ INSOLUBLE EN AGUA QUE CONTIENE LECTINA CON ANTITROMBINA LIGADA DE FORMA REVERSIBLE A LA MISMA, SIENDO COMPLEJADA LA HEPARINA DE ALTA ACTIVIDAD A LA ANTITROMBINA DE LA MATRIZ. 2<002> SEPARAR LA HEPARINA SIN LIGAR, QUE CONTIENE HEPARINA DE BAJA ACTIVIDAD DE LA MATRIZ. 3<002> SEPARAR DE LA MATRIZ UN COMPLEJO DE ANTITROMBINA-HEPARINA DE ALTA ACTIVIDAD. LA LECTINA ES CONCANAVALINA A, MIENTRAS QUE LA MATRIZ RESOLUBLE EN AGUA ES UNA SAL DE AGAROSA.
ES505911A 1980-09-30 1981-09-30 Procedimiento para preparar un complejo de antitrombina y de heparina de alta actividad. Granted ES505911A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19217080A 1980-09-30 1980-09-30

Publications (2)

Publication Number Publication Date
ES8302460A1 true ES8302460A1 (es) 1982-12-01
ES505911A0 ES505911A0 (es) 1982-12-01

Family

ID=22708546

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505911A Granted ES505911A0 (es) 1980-09-30 1981-09-30 Procedimiento para preparar un complejo de antitrombina y de heparina de alta actividad.

Country Status (7)

Country Link
EP (1) EP0048898B1 (es)
JP (1) JPS5788125A (es)
AT (1) ATE12779T1 (es)
AU (1) AU553260B2 (es)
CA (1) CA1187074A (es)
DE (1) DE3170001D1 (es)
ES (1) ES505911A0 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0098814B1 (en) * 1982-06-10 1986-10-15 KabiVitrum AB Antithrombin-heparin complex
US4689323A (en) * 1983-09-26 1987-08-25 Miles Laboratories, Inc. Covalently bound heparin--antithrombin-III complex
EP0209924A1 (en) * 1985-07-12 1987-01-28 Akzo N.V. New anti-trombosis agent based on glycosaminoglycan, process for its preparation, and pharmaceutical compositions
DK148890D0 (da) * 1990-06-19 1990-06-19 Novo Nordisk As Farmaceutisk praeparat
KR100220538B1 (ko) * 1991-01-11 1999-09-15 뮈쉘 쥐르밀 아크리딘 유도체
AT405905B (de) * 1997-03-25 1999-12-27 Immuno Ag Neue verwendung von antithrombin iii
EP1362127B1 (en) * 2001-01-26 2007-11-07 The General Hospital Corporation Serpin drugs for treatment of hiv infection and method of use thereof
FR2889078B1 (fr) * 2005-07-27 2007-11-02 Aventis Pharma Sa Nouvelle methode de chromatographie d'affinite d'antithrombine iii

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6040859B2 (ja) * 1977-07-27 1985-09-12 喜温 三浦 抗血栓性人工医療材料
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法

Also Published As

Publication number Publication date
AU553260B2 (en) 1986-07-10
JPS5788125A (en) 1982-06-01
EP0048898B1 (en) 1985-04-17
CA1187074A (en) 1985-05-14
EP0048898A3 (en) 1982-09-15
AU7578581A (en) 1982-04-08
ES505911A0 (es) 1982-12-01
EP0048898A2 (en) 1982-04-07
DE3170001D1 (en) 1985-05-23
JPH0153650B2 (es) 1989-11-15
ATE12779T1 (de) 1985-05-15

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