ES8302629A1 - Doxycycline monosodium tetrametaphosphate complexes and their preparation - Google Patents

Doxycycline monosodium tetrametaphosphate complexes and their preparation

Info

Publication number
ES8302629A1
ES8302629A1 ES507293A ES507293A ES8302629A1 ES 8302629 A1 ES8302629 A1 ES 8302629A1 ES 507293 A ES507293 A ES 507293A ES 507293 A ES507293 A ES 507293A ES 8302629 A1 ES8302629 A1 ES 8302629A1
Authority
ES
Spain
Prior art keywords
tetrametaphosphate
doxycycline
monosodium
preparation
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507293A
Other languages
Spanish (es)
Other versions
ES507293A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES8302629A1 publication Critical patent/ES8302629A1/en
Publication of ES507293A0 publication Critical patent/ES507293A0/en
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/04—Sodium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Doxycycline monosodium tetrametaphosphate, and ethanol-water and isopropanol-water solvates thereof have anti-bactericidal properties. Processes for their preparation and pharmaceutical compositions containing them are described.
ES507293A 1980-11-25 1981-11-19 PROCESS OF PREPARATION OF A COMPLEX SOLUBLE IN WATER OF AL-FA-6-DESOXI-5-HIDROXITETRACICLINA AND SODIUM TETRAMETAFOSFATO. Granted ES507293A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT72107A PT72107B (en) 1980-11-25 1980-11-25 PROCESS FOR PREPARING A WATER SOLUBLE COMPLEX OF ALPHA-6-DIOXI-5-HYDROXITETRACYCLINE AND DESODIUM TETRAMETAPHOSPHATE

Publications (2)

Publication Number Publication Date
ES8302629A1 true ES8302629A1 (en) 1983-02-01
ES507293A0 ES507293A0 (en) 1983-02-01

Family

ID=20082809

Family Applications (1)

Application Number Title Priority Date Filing Date
ES507293A Granted ES507293A0 (en) 1980-11-25 1981-11-19 PROCESS OF PREPARATION OF A COMPLEX SOLUBLE IN WATER OF AL-FA-6-DESOXI-5-HIDROXITETRACICLINA AND SODIUM TETRAMETAFOSFATO.

Country Status (13)

Country Link
JP (1) JPS57116033A (en)
KR (1) KR860000450B1 (en)
AU (1) AU543041B2 (en)
BE (1) BE891236A (en)
DE (1) DE3146279A1 (en)
ES (1) ES507293A0 (en)
FR (1) FR2494685A1 (en)
GB (1) GB2088864B (en)
HK (1) HK10687A (en)
NL (1) NL190067C (en)
PH (1) PH20236A (en)
PT (1) PT72107B (en)
ZA (1) ZA817804B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
NZ544826A (en) 2003-07-25 2008-07-31 Warner Chilcott Co Inc A doxycycline metal complex in a solid dosage form

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1068701B (en) * 1959-11-12 Bristol Laboratories Inc., East Syracuse, N. Y. (V. St. A.) Process for the preparation of antibiotic tetracycline sodium hexametaphosphate
BE568762A (en) *
US2791609A (en) * 1956-09-27 1957-05-07 Murray A Kaplan Tetracycline metallo-phosphate complexes and method preparation
US2795528A (en) * 1956-10-24 1957-06-11 Frank H Buckwalter Therapeutic composition containing a tetracycline and a phosphate other than orthophosphate
US3053892A (en) * 1960-04-27 1962-09-11 American Cyanamid Co Metaphosphoric acid complexes of tetracycline and its analogs
US3068264A (en) * 1961-06-06 1962-12-11 American Cyanamid Co Tetracycline antibiotic-aluminumphosphoric acid complexes
GB1180701A (en) * 1967-06-23 1970-02-11 Pfizer & Co C Process for Purifying Tetracycline Antibiotics with Phosphate Salts
ES396132A1 (en) * 1970-10-30 1972-12-01 Villax Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation
JPS5745215A (en) * 1980-09-01 1982-03-15 Toshiba Corp Molding device of iron plate for wound core

Also Published As

Publication number Publication date
PT72107A (en) 1980-12-01
KR830007076A (en) 1983-10-14
ZA817804B (en) 1982-12-29
FR2494685B1 (en) 1985-02-01
HK10687A (en) 1987-02-06
AU7761281A (en) 1982-06-03
NL190067C (en) 1993-10-18
GB2088864A (en) 1982-06-16
DE3146279A1 (en) 1982-08-19
AU543041B2 (en) 1985-03-28
JPS57116033A (en) 1982-07-19
ES507293A0 (en) 1983-02-01
KR860000450B1 (en) 1986-04-26
BE891236A (en) 1982-05-24
PH20236A (en) 1986-11-10
NL8105309A (en) 1982-06-16
NL190067B (en) 1993-05-17
GB2088864B (en) 1984-09-12
FR2494685A1 (en) 1982-05-28
PT72107B (en) 1981-10-28

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