ES8302694A1 - "un procedimiento para la preparacion de un derivado de imidazolina". - Google Patents
"un procedimiento para la preparacion de un derivado de imidazolina".Info
- Publication number
- ES8302694A1 ES8302694A1 ES509131A ES509131A ES8302694A1 ES 8302694 A1 ES8302694 A1 ES 8302694A1 ES 509131 A ES509131 A ES 509131A ES 509131 A ES509131 A ES 509131A ES 8302694 A1 ES8302694 A1 ES 8302694A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- imidazoline derivatives
- compositions containing
- cycloalkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002462 imidazolines Chemical class 0.000 title abstract 2
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 abstract 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003518 presynaptic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE IMIDAZOLINA. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (I), EN LA QUE R ES ALCOHILO C <003> ; R PUEDE SER UNO DE VARIOS RADICALES, Y HX ES UN ACIDO, CON ETILENDIAMINA, EN METANOL O ETANOL, CON LO QUE SE OBTIENE UN COMPUESTO DE FORMULA (II), EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I). EL COMPUESTO OBTENIDO SE PUEDE HIDROGENAR EN PRESENCIA DE UN CATALIZADOR DE PALADIO SOBRE CARBONO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL BLOQUEO DE LOS ADRENORRECEPTORES PRESINAPTICOS <007> .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8102906 | 1981-01-30 | ||
| GB8123277 | 1981-07-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8302694A1 true ES8302694A1 (es) | 1983-01-16 |
| ES509131A0 ES509131A0 (es) | 1983-01-16 |
Family
ID=26278285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509131A Granted ES509131A0 (es) | 1981-01-30 | 1982-01-28 | "un procedimiento para la preparacion de un derivado de imidazolina". |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4397860A (es) |
| EP (1) | EP0058006B1 (es) |
| AR (1) | AR229957A1 (es) |
| AU (1) | AU545344B2 (es) |
| CA (1) | CA1176638A (es) |
| CS (1) | CS245766B2 (es) |
| DE (1) | DE3262919D1 (es) |
| DK (1) | DK40482A (es) |
| ES (1) | ES509131A0 (es) |
| FI (1) | FI67544C (es) |
| GB (1) | GB2092139B (es) |
| GR (1) | GR75168B (es) |
| HU (1) | HU190983B (es) |
| IE (1) | IE52310B1 (es) |
| IL (1) | IL64880A (es) |
| NO (1) | NO156865C (es) |
| NZ (1) | NZ199469A (es) |
| PH (1) | PH17747A (es) |
| PL (1) | PL137716B1 (es) |
| PT (1) | PT74354B (es) |
| SU (1) | SU1197566A3 (es) |
| ZW (1) | ZW1882A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ203680A (en) * | 1982-04-17 | 1985-08-16 | Reckitt & Colmann Prod Ltd | Imidazolines and pharmaceutical compositions |
| US4634714A (en) * | 1983-12-01 | 1987-01-06 | American Home Products Corporation | Inhibition of prolactin release by a benzodioxinylimidazoline derivative |
| FR2698789B1 (fr) * | 1992-12-07 | 1995-03-03 | Pf Medicament | Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution. |
| FR2700113B1 (fr) * | 1993-01-07 | 1995-03-24 | Pf Medicament | Utilisation de l'Idazoxan et ses dérivés pour la fabrication de médicaments destinés au traitement des maladies neurodégénératives et en particulier l'évolution de la maladie d'Alzheimer. |
| US6162455A (en) * | 1997-01-22 | 2000-12-19 | American Cyanamid Company | Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals |
| FR2766824B1 (fr) * | 1997-07-30 | 1999-09-10 | Adir | Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6650943B1 (en) | 2000-04-07 | 2003-11-18 | Advanced Bionics Corporation | Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction |
| US6885895B1 (en) * | 2001-04-26 | 2005-04-26 | Advanced Bionics Corporation | Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction |
| US20050240229A1 (en) * | 2001-04-26 | 2005-10-27 | Whitehurst Tood K | Methods and systems for stimulation as a therapy for erectile dysfunction |
| RU2223450C1 (ru) * | 2002-06-25 | 2004-02-10 | Долотовский Владимир Васильевич | Водонагреватель емкостной газовый |
| CN103030646B (zh) * | 2011-09-29 | 2016-08-24 | 上海恒瑞医药有限公司 | 苯并二氧六环类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2979511A (en) * | 1959-03-25 | 1961-04-11 | Olin Mathieson | Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process |
| PH16249A (en) * | 1980-02-04 | 1983-08-16 | Reckitt & Colmann Prod Ltd | Imidazoline derivatives,its pharmaceutical composition and method of use |
-
1982
- 1982-01-12 NZ NZ199469A patent/NZ199469A/en unknown
- 1982-01-13 CA CA000394056A patent/CA1176638A/en not_active Expired
- 1982-01-18 US US06/340,461 patent/US4397860A/en not_active Expired - Fee Related
- 1982-01-22 GB GB8201828A patent/GB2092139B/en not_active Expired
- 1982-01-25 EP EP82300365A patent/EP0058006B1/en not_active Expired
- 1982-01-25 DE DE8282300365T patent/DE3262919D1/de not_active Expired
- 1982-01-26 AR AR288247A patent/AR229957A1/es active
- 1982-01-26 PH PH26794A patent/PH17747A/en unknown
- 1982-01-27 FI FI820262A patent/FI67544C/fi not_active IP Right Cessation
- 1982-01-28 GR GR67143A patent/GR75168B/el unknown
- 1982-01-28 NO NO820258A patent/NO156865C/no unknown
- 1982-01-28 ES ES509131A patent/ES509131A0/es active Granted
- 1982-01-28 SU SU823385605A patent/SU1197566A3/ru active
- 1982-01-28 AU AU79926/82A patent/AU545344B2/en not_active Ceased
- 1982-01-28 IL IL64880A patent/IL64880A/xx unknown
- 1982-01-29 CS CS82631A patent/CS245766B2/cs unknown
- 1982-01-29 IE IE209/82A patent/IE52310B1/en unknown
- 1982-01-29 ZW ZW18/82A patent/ZW1882A1/xx unknown
- 1982-01-29 HU HU82273A patent/HU190983B/hu not_active IP Right Cessation
- 1982-01-29 PT PT74354A patent/PT74354B/pt unknown
- 1982-01-29 DK DK40482A patent/DK40482A/da not_active Application Discontinuation
- 1982-02-19 PL PL1982235152A patent/PL137716B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL64880A0 (en) | 1982-03-31 |
| PH17747A (en) | 1984-11-27 |
| DK40482A (da) | 1982-07-31 |
| PL235152A1 (en) | 1983-07-18 |
| NO820258L (no) | 1982-08-02 |
| EP0058006A1 (en) | 1982-08-18 |
| NO156865C (no) | 1987-12-09 |
| ZW1882A1 (en) | 1982-06-23 |
| EP0058006B1 (en) | 1985-04-10 |
| IE52310B1 (en) | 1987-09-02 |
| AU7992682A (en) | 1982-08-05 |
| GR75168B (es) | 1984-07-13 |
| NO156865B (no) | 1987-08-31 |
| NZ199469A (en) | 1984-03-16 |
| HU190983B (en) | 1986-12-28 |
| AR229957A1 (es) | 1984-01-31 |
| DE3262919D1 (en) | 1985-05-15 |
| IL64880A (en) | 1985-04-30 |
| PT74354A (en) | 1982-02-01 |
| PL137716B1 (en) | 1986-07-31 |
| GB2092139B (en) | 1984-10-31 |
| FI67544B (fi) | 1984-12-31 |
| US4397860A (en) | 1983-08-09 |
| CA1176638A (en) | 1984-10-23 |
| AU545344B2 (en) | 1985-07-11 |
| SU1197566A3 (ru) | 1985-12-07 |
| FI67544C (fi) | 1985-04-10 |
| CS245766B2 (en) | 1986-10-16 |
| FI820262L (fi) | 1982-07-31 |
| IE820209L (en) | 1982-07-30 |
| GB2092139A (en) | 1982-08-11 |
| ES509131A0 (es) | 1983-01-16 |
| PT74354B (en) | 1983-07-04 |
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