ES8302731A1 - "PROCEDURE FOR THE PREPARATION OF NEW 4'-YODODERIVES OF ANTHRACICLINE GLYCOSIDES". - Google Patents
"PROCEDURE FOR THE PREPARATION OF NEW 4'-YODODERIVES OF ANTHRACICLINE GLYCOSIDES".Info
- Publication number
- ES8302731A1 ES8302731A1 ES511537A ES511537A ES8302731A1 ES 8302731 A1 ES8302731 A1 ES 8302731A1 ES 511537 A ES511537 A ES 511537A ES 511537 A ES511537 A ES 511537A ES 8302731 A1 ES8302731 A1 ES 8302731A1
- Authority
- ES
- Spain
- Prior art keywords
- yododerives
- glycosides
- procedure
- anthracicline
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182470 glycoside Natural products 0.000 title abstract 2
- 150000002338 glycosides Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 208000008342 Leukemia P388 Diseases 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001875 compounds Chemical group 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Procedure for the obtaining of 4 '' - yododerives of glycosides of antracicline, of formula (I), in which r is hydrogen or hydroxy; compounds that have pharmacological applications to inhibit the growth of tumors such as leukemia p388 or leukemia de gross. It consists of the soft alkaline hydrolytic reaction of the 4 '' - doxi-4 '' - iodo-N-trifluoroacetildaunorrubicina in aqueous dissolution of 0.1n sodium hydroxide. The obtained product is extracted with chloroform, the aqueous solution is adjusted to ph 8.6, and it is challenged again with chloroform, the extracts are dried, concentrated and acidified with 0.1n methanolic hydrogen chloride to crystallize. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES511537A ES8302731A1 (en) | 1982-04-20 | 1982-04-20 | "PROCEDURE FOR THE PREPARATION OF NEW 4'-YODODERIVES OF ANTHRACICLINE GLYCOSIDES". |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES511537A ES8302731A1 (en) | 1982-04-20 | 1982-04-20 | "PROCEDURE FOR THE PREPARATION OF NEW 4'-YODODERIVES OF ANTHRACICLINE GLYCOSIDES". |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES511537A0 ES511537A0 (en) | 1983-02-01 |
| ES8302731A1 true ES8302731A1 (en) | 1983-02-01 |
Family
ID=8484022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES511537A Expired ES8302731A1 (en) | 1982-04-20 | 1982-04-20 | "PROCEDURE FOR THE PREPARATION OF NEW 4'-YODODERIVES OF ANTHRACICLINE GLYCOSIDES". |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8302731A1 (en) |
-
1982
- 1982-04-20 ES ES511537A patent/ES8302731A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES511537A0 (en) | 1983-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted |