ES8302734A1 - Procedimiento para preparar 5'-n-(aminoalquil)-amino-5'-deo-xiadenosina - Google Patents
Procedimiento para preparar 5'-n-(aminoalquil)-amino-5'-deo-xiadenosinaInfo
- Publication number
- ES8302734A1 ES8302734A1 ES500452A ES500452A ES8302734A1 ES 8302734 A1 ES8302734 A1 ES 8302734A1 ES 500452 A ES500452 A ES 500452A ES 500452 A ES500452 A ES 500452A ES 8302734 A1 ES8302734 A1 ES 8302734A1
- Authority
- ES
- Spain
- Prior art keywords
- alkylene
- hydrogen
- alkyl
- substituted
- deoxyadenosine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- -1 5'-deoxyadenosin-5'-yl Chemical group 0.000 abstract 1
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002831 pharmacologic agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 5''-N-(AMINOALQUIL)-AMINO-5''-DEOXIADENOSINA Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE AD ES ADENIN-9-IL; R ES ALQUILENO C <003> ; Y R Y R PUEDEN SER VARIOS RADICALES. CONSISTE EN EL TRATAMIENTO DE UNA 5''-N-(AMINOALQUIL)-AMINO-5''-DEOXIADENOSINA-2'',3''-HIDROXI-PROTEGIDA DE FORMULA (II) EN LA QUE AD, R , R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y R Y R SON GRUPOS BLOQUEADORES. LA REACCION TIENE POR OBJETO SEPARAR LOS GRUPOS BLOQUEADORES DE HIDROXI. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LEUCEMIAS, TUMORES SOLIDOS Y LINFOMAS Y PARA EL CONTROL DE INFECCIONES PARASITAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8009995 | 1980-03-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8302734A1 true ES8302734A1 (es) | 1983-02-01 |
| ES500452A0 ES500452A0 (es) | 1983-02-01 |
Family
ID=10512359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500452A Granted ES500452A0 (es) | 1980-03-25 | 1981-03-17 | Procedimiento para preparar 5'-n-(aminoalquil)-amino-5'-deo-xiadenosina |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4374128A (es) |
| EP (1) | EP0037310B1 (es) |
| JP (1) | JPS56164199A (es) |
| AU (1) | AU536796B2 (es) |
| CA (1) | CA1182817A (es) |
| DE (1) | DE3163462D1 (es) |
| ES (1) | ES500452A0 (es) |
| GB (1) | GB2073743B (es) |
| IL (1) | IL62352A (es) |
| ZA (1) | ZA811555B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5547662A (en) * | 1993-08-27 | 1996-08-20 | Becton, Dickinson And Company | Preparation of a skin surface for a surgical procedure |
| US5684042A (en) * | 1997-01-10 | 1997-11-04 | Medlogic Global Corporation | Cyanoacrylate compositions comprising an antimicrobial agent |
| US6534651B2 (en) * | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3809689A (en) * | 1971-02-25 | 1974-05-07 | Syntex Inc | Synthetic polyoxin type nucleosides and methods of preparing |
| US4087603A (en) * | 1976-09-27 | 1978-05-02 | Eli Lilly And Company | Antifungal antibiotics |
| FR2387244A1 (fr) * | 1977-04-13 | 1978-11-10 | Anvar | Derives amines de la 5'-deoxy-adenosine |
| US4086416A (en) * | 1977-05-17 | 1978-04-25 | Stanford Research Institute | Septacidin analogs |
| US4139563A (en) * | 1977-07-01 | 1979-02-13 | Merrell Toraude Et Compagnie | α-ACETYLENIC DERIVATIVES OF AMINES |
| US4182891A (en) * | 1977-07-01 | 1980-01-08 | Merrell Toraude Et Compagnie | α-Acetylenic derivatives of α-amino acids |
| US4134918A (en) * | 1977-09-06 | 1979-01-16 | Merrell Toraude Et Compagnie | Alpha-halomethyl derivatives of amines |
-
1981
- 1981-03-09 ZA ZA00811555A patent/ZA811555B/xx unknown
- 1981-03-10 CA CA000372620A patent/CA1182817A/en not_active Expired
- 1981-03-10 GB GB8107433A patent/GB2073743B/en not_active Expired
- 1981-03-12 IL IL62352A patent/IL62352A/xx unknown
- 1981-03-13 US US06/243,280 patent/US4374128A/en not_active Expired - Lifetime
- 1981-03-17 ES ES500452A patent/ES500452A0/es active Granted
- 1981-03-18 EP EP81400420A patent/EP0037310B1/en not_active Expired
- 1981-03-18 DE DE8181400420T patent/DE3163462D1/de not_active Expired
- 1981-03-19 AU AU68544/81A patent/AU536796B2/en not_active Ceased
- 1981-03-24 JP JP4185181A patent/JPS56164199A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB2073743A (en) | 1981-10-21 |
| AU536796B2 (en) | 1984-05-24 |
| DE3163462D1 (de) | 1984-06-14 |
| IL62352A0 (en) | 1981-05-20 |
| CA1182817A (en) | 1985-02-19 |
| AU6854481A (en) | 1981-10-01 |
| IL62352A (en) | 1984-03-30 |
| ZA811555B (en) | 1982-03-31 |
| JPH0132837B2 (es) | 1989-07-10 |
| JPS56164199A (en) | 1981-12-17 |
| EP0037310A1 (en) | 1981-10-07 |
| GB2073743B (en) | 1983-06-08 |
| US4374128A (en) | 1983-02-15 |
| ES500452A0 (es) | 1983-02-01 |
| EP0037310B1 (en) | 1984-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |