ES8303300A1 - "procedimiento para la preparacion de nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos". - Google Patents

"procedimiento para la preparacion de nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos".

Info

Publication number
ES8303300A1
ES8303300A1 ES509513A ES509513A ES8303300A1 ES 8303300 A1 ES8303300 A1 ES 8303300A1 ES 509513 A ES509513 A ES 509513A ES 509513 A ES509513 A ES 509513A ES 8303300 A1 ES8303300 A1 ES 8303300A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
treatment
alkinyl
acylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509513A
Other languages
English (en)
Other versions
ES509513A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
C.H. Boehringer Sohn AG and Co KG
Original Assignee
C.H. Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn AG and Co KG filed Critical C.H. Boehringer Sohn AG and Co KG
Publication of ES8303300A1 publication Critical patent/ES8303300A1/es
Publication of ES509513A0 publication Critical patent/ES509513A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-(ACILAMINO-ARILOXI)-2-HIDROXI-3-ALQUINILAMINOPROPANOS Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES ALCOHILO C <- ; Y R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DERIVADO DE OXAZOLIDINA, DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO POR TRATAMIENTO A REFLUJO DEL COMPUESTO DISUELTO EN ALCOHOL, EN PRESENCIA DE UNA AMINA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ARRITMIAS CARDIACAS Y POR SUS PROPIEDADES HIPOTENSORAS.
ES509513A 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos". Granted ES509513A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803009047 DE3009047A1 (de) 1980-03-08 1980-03-08 Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8303300A1 true ES8303300A1 (es) 1983-02-01
ES509513A0 ES509513A0 (es) 1983-02-01

Family

ID=6096693

Family Applications (3)

Application Number Title Priority Date Filing Date
ES500154A Expired ES8205396A1 (es) 1980-03-08 1981-03-06 Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos
ES509513A Granted ES509513A0 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos".
ES509514A Granted ES509514A0 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES500154A Expired ES8205396A1 (es) 1980-03-08 1981-03-06 Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES509514A Granted ES509514A0 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos".

Country Status (18)

Country Link
US (1) US4609672A (es)
EP (1) EP0035733B1 (es)
JP (1) JPS56139448A (es)
AT (1) ATE4639T1 (es)
AU (1) AU541492B2 (es)
CA (1) CA1150735A (es)
DE (2) DE3009047A1 (es)
DK (1) DK102581A (es)
ES (3) ES8205396A1 (es)
FI (1) FI74272C (es)
GB (1) GB2071096B (es)
GR (1) GR74907B (es)
IE (1) IE52015B1 (es)
IL (1) IL62308A (es)
NO (1) NO150961C (es)
NZ (1) NZ196445A (es)
PT (1) PT72620B (es)
ZA (1) ZA811499B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3133719A1 (de) * 1981-08-26 1983-03-10 Boehringer Ingelheim KG, 6507 Ingelheim Neue 1-aryloxy-3-alkinylamino-2-propanole und verfahren zu ihrer herstellung
HK1040187B (zh) 1998-09-10 2005-09-02 萨诺费－阿文蒂斯德国有限公司 苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH546227A (en) * 1969-08-08 1974-02-28 Boehringer Sohn Ingelheim 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane
CH546224A (en) * 1969-08-08 1974-02-28 Boehringer Sohn Ingelheim 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane
DE2403809C2 (de) * 1974-01-26 1986-02-27 C.H. Boehringer Sohn, 6507 Ingelheim 1-Aryloxy-2-hydroxy-3-alkinylaminopropane und Verfahren zu ihrer Herstellung und pharmazeutische Präparate
DE2309887C2 (de) * 1973-02-28 1983-11-10 C.H. Boehringer Sohn, 6507 Ingelheim 1-Aryloxy-2-hydroxy-3-alkinylaminopropan-Derivate und deren physiologisch verträgliche Säureadditionssalze, pharmazeutische Präparate und Herstellungsverfahren für die Verbindungen
AT330150B (de) * 1973-02-28 1976-06-10 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen
DE3009036A1 (de) * 1980-03-08 1981-09-24 C.H. Boehringer Sohn, 6507 Ingelheim Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NO810764L (no) 1981-09-09
ES8302638A1 (es) 1983-01-16
IE810486L (en) 1981-09-08
PT72620A (de) 1981-04-01
NZ196445A (en) 1984-05-31
AU541492B2 (en) 1985-01-10
EP0035733A1 (de) 1981-09-16
FI74272C (fi) 1988-01-11
IL62308A0 (en) 1981-05-20
DK102581A (da) 1981-09-09
US4609672A (en) 1986-09-02
GB2071096B (en) 1983-09-14
FI810714L (fi) 1981-09-09
IE52015B1 (en) 1987-05-27
PT72620B (de) 1982-11-15
ES509514A0 (es) 1983-01-16
EP0035733B1 (de) 1983-09-14
DE3009047A1 (de) 1981-09-24
IL62308A (en) 1984-12-31
GB2071096A (en) 1981-09-16
AU6815781A (en) 1981-09-17
JPS56139448A (en) 1981-10-30
ES500154A0 (es) 1982-06-01
CA1150735A (en) 1983-07-26
DE3160861D1 (en) 1983-10-20
NO150961B (no) 1984-10-08
ATE4639T1 (de) 1983-09-15
NO150961C (no) 1985-01-16
ZA811499B (en) 1982-11-24
ES8205396A1 (es) 1982-06-01
FI74272B (fi) 1987-09-30
GR74907B (es) 1984-07-12
ES509513A0 (es) 1983-02-01

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