ES8303399A1 - "un metodo para preparar una 2-(piridilbutilamino)-pirimidona". - Google Patents
"un metodo para preparar una 2-(piridilbutilamino)-pirimidona".Info
- Publication number
- ES8303399A1 ES8303399A1 ES512426A ES512426A ES8303399A1 ES 8303399 A1 ES8303399 A1 ES 8303399A1 ES 512426 A ES512426 A ES 512426A ES 512426 A ES512426 A ES 512426A ES 8303399 A1 ES8303399 A1 ES 8303399A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridyl
- chemical process
- methoxy
- methyl
- yrimid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001311 chemical methods and process Methods 0.000 title 1
- AYWOFJWEAQSKPI-UHFFFAOYSA-N 2-[4-(3-methoxypyridin-2-yl)butyl]guanidine Chemical compound COC1=CC=CN=C1CCCCN=C(N)N AYWOFJWEAQSKPI-UHFFFAOYSA-N 0.000 abstract 1
- RZBQEWDGNIUYHR-UHFFFAOYSA-N 2-formyl-3-(6-methylpyridin-3-yl)propanoic acid Chemical compound CC1=CC=C(CC(C=O)C(O)=O)C=N1 RZBQEWDGNIUYHR-UHFFFAOYSA-N 0.000 abstract 1
- 125000006309 butyl amino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 2-(PIRIDILBUTILAMINO)-PIRIMIDONA, DE FORMULA (I), Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE UNA GUANIDINA DE FORMULA (II), CON UN 2-FORMIL-3-PIRIDINIL PROPIONATO, DE FORMULA (III), EN LA QUE ALK ES ALCOHILO INFERIOR C <- . LA REACCION SE LLEVA A CABO EN EL SISTEMA DISOLVENTE AGUA/HIDROCARBURO HALOGENADO, EN MEDIO NEUTRO O DEBILMENTE BASICO, EN PRESENCIA DE UN AGENTE DE TRANSFERENCIA DE FASE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD DE BLOQUEO DEL RECEPTOR H DE LA HISTAMINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8116156 | 1981-05-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8303399A1 true ES8303399A1 (es) | 1983-02-01 |
| ES512426A0 ES512426A0 (es) | 1983-02-01 |
Family
ID=10522080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES512426A Granted ES512426A0 (es) | 1981-05-27 | 1982-05-21 | "un metodo para preparar una 2-(piridilbutilamino)-pirimidona". |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0066442B1 (es) |
| JP (1) | JPS57200365A (es) |
| AT (1) | ATE14581T1 (es) |
| AU (1) | AU548256B2 (es) |
| DE (1) | DE3265063D1 (es) |
| DK (1) | DK234982A (es) |
| ES (1) | ES512426A0 (es) |
| GR (1) | GR75490B (es) |
| IE (1) | IE52967B1 (es) |
| PT (1) | PT74865B (es) |
| ZA (1) | ZA823607B (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1564502A (en) * | 1975-07-31 | 1980-04-10 | Smith Kline French Lab | Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives |
| US4154834A (en) * | 1975-12-29 | 1979-05-15 | Smith Kline & French Laboratories Limited | Substituted isocytosines having histamine H2 -antagonist activity |
| PH16240A (en) * | 1978-04-11 | 1983-08-11 | Smith Kline French Lab | Process for making histamine antagonist |
| AU531142B2 (en) * | 1979-04-04 | 1983-08-11 | Smith Kline & French Laboratories Limited | 2 amino- pyimindones |
| ZW21281A1 (en) * | 1980-10-01 | 1981-11-18 | Smith Kline French Lab | Amine derivatives |
-
1982
- 1982-05-10 PT PT74865A patent/PT74865B/pt unknown
- 1982-05-21 ES ES512426A patent/ES512426A0/es active Granted
- 1982-05-22 JP JP57087182A patent/JPS57200365A/ja active Pending
- 1982-05-24 AU AU84103/82A patent/AU548256B2/en not_active Ceased
- 1982-05-25 EP EP82302664A patent/EP0066442B1/en not_active Expired
- 1982-05-25 ZA ZA823607A patent/ZA823607B/xx unknown
- 1982-05-25 GR GR68256A patent/GR75490B/el unknown
- 1982-05-25 DK DK234982A patent/DK234982A/da not_active Application Discontinuation
- 1982-05-25 DE DE8282302664T patent/DE3265063D1/de not_active Expired
- 1982-05-25 AT AT82302664T patent/ATE14581T1/de active
- 1982-05-26 IE IE1263/82A patent/IE52967B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8410382A (en) | 1982-12-02 |
| EP0066442B1 (en) | 1985-07-31 |
| ES512426A0 (es) | 1983-02-01 |
| AU548256B2 (en) | 1985-12-05 |
| EP0066442A1 (en) | 1982-12-08 |
| IE52967B1 (en) | 1988-04-27 |
| JPS57200365A (en) | 1982-12-08 |
| ZA823607B (en) | 1983-03-30 |
| IE821263L (en) | 1982-11-27 |
| GR75490B (es) | 1984-07-23 |
| DK234982A (da) | 1982-11-28 |
| PT74865A (en) | 1982-06-01 |
| DE3265063D1 (en) | 1985-09-05 |
| ATE14581T1 (de) | 1985-08-15 |
| PT74865B (en) | 1983-12-07 |
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