ES8303416A1 - "un procedimiento de preparacion de imidazo (1,2-a) pirimidinas". - Google Patents

"un procedimiento de preparacion de imidazo (1,2-a) pirimidinas".

Info

Publication number
ES8303416A1
ES8303416A1 ES510725A ES510725A ES8303416A1 ES 8303416 A1 ES8303416 A1 ES 8303416A1 ES 510725 A ES510725 A ES 510725A ES 510725 A ES510725 A ES 510725A ES 8303416 A1 ES8303416 A1 ES 8303416A1
Authority
ES
Spain
Prior art keywords
radical
4alkyl
pyrimidines
imidazo
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510725A
Other languages
English (en)
Other versions
ES510725A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES8303416A1 publication Critical patent/ES8303416A1/es
Publication of ES510725A0 publication Critical patent/ES510725A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE IMIDAZO 1,2-A PIRIMIDINAS Y DE SUS SALES DE ADICION FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UNA DICETONA DE FORMULA R CO-CHBR-COR , EN LA QUE R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON AMINO-2-PIRIMIDINA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 20 C Y 100 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD EN EL CAMPO DEL SISTEMA NERVIOSO CENTRAL.
ES510725A 1981-03-25 1982-03-24 "un procedimiento de preparacion de imidazo (1,2-a) pirimidinas". Granted ES510725A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8106006A FR2502622A1 (fr) 1981-03-25 1981-03-25 Derives d'imidazo (1,2-a) pyrimidines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES8303416A1 true ES8303416A1 (es) 1983-02-01
ES510725A0 ES510725A0 (es) 1983-02-01

Family

ID=9256644

Family Applications (1)

Application Number Title Priority Date Filing Date
ES510725A Granted ES510725A0 (es) 1981-03-25 1982-03-24 "un procedimiento de preparacion de imidazo (1,2-a) pirimidinas".

Country Status (12)

Country Link
EP (1) EP0061380A1 (es)
JP (1) JPS57169482A (es)
AU (1) AU8187482A (es)
DK (1) DK133482A (es)
ES (1) ES510725A0 (es)
FI (1) FI821035A7 (es)
FR (1) FR2502622A1 (es)
GR (1) GR75931B (es)
IL (1) IL65337A0 (es)
NO (1) NO820980L (es)
PT (2) PT74651B (es)
ZA (1) ZA822009B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69417A (en) * 1982-08-27 1987-12-20 Roussel Uclaf 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them
US4537889A (en) * 1982-12-27 1985-08-27 Eli Lilly And Company Inotropic agents
RO87859B (ro) * 1982-12-27 1985-12-31 Eli Lilly And Company Procedeu pentru prepararea unor derivati de inidazopirimidina pirezina si triazina
US4636502A (en) * 1982-12-27 1987-01-13 Eli Lilly And Company Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines
GB8334210D0 (en) * 1983-12-22 1984-02-01 Roussel Lab Ltd Imidazo(1 2-c)pyrimidines
GB8620060D0 (en) * 1986-08-18 1986-10-01 Roussel Lab Ltd Chemical compounds
US4731446A (en) * 1987-05-01 1988-03-15 The Dow Chemical Company Imidazo[1,2-a]pyrimidine sulfonic acids and acid halides
FR2699919B1 (fr) * 1992-12-24 1995-01-27 Synthelabo Dérivés d'imidazole, leur procédé de préparation et leur application en thérapeutique.
WO2018090921A1 (zh) * 2016-11-16 2018-05-24 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
CN108084186B (zh) * 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
WO2019141259A1 (zh) * 2018-01-19 2019-07-25 苏州信诺维医药科技有限公司 杂环化合物、制备方法及其在医药上的应用

Also Published As

Publication number Publication date
EP0061380A1 (fr) 1982-09-29
NO820980L (no) 1982-09-27
JPS57169482A (en) 1982-10-19
GR75931B (es) 1984-08-02
FI821035L (fi) 1982-09-26
ES510725A0 (es) 1983-02-01
IL65337A0 (en) 1982-05-31
PT74651B (fr) 1984-11-26
FR2502622A1 (fr) 1982-10-01
PT74651A (fr) 1982-04-01
ZA822009B (en) 1983-02-23
DK133482A (da) 1982-09-26
PT74652B (fr) 1984-12-04
FI821035A7 (fi) 1982-09-26
AU8187482A (en) 1982-09-30
FR2502622B1 (es) 1983-08-05
FI821035A0 (fi) 1982-03-24
PT74652A (fr) 1982-04-01

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