ES8304093A1 - Un procedimiento para la preparacion de una n-(fenil)-n'(1,4,5,6-tetrahidropiridin-2-il) o (4,5,6,7-tetrahidro-1h-1,3- diazepin-2-il) urea - Google Patents

Un procedimiento para la preparacion de una n-(fenil)-n'(1,4,5,6-tetrahidropiridin-2-il) o (4,5,6,7-tetrahidro-1h-1,3- diazepin-2-il) urea

Info

Publication number
ES8304093A1
ES8304093A1 ES503013A ES503013A ES8304093A1 ES 8304093 A1 ES8304093 A1 ES 8304093A1 ES 503013 A ES503013 A ES 503013A ES 503013 A ES503013 A ES 503013A ES 8304093 A1 ES8304093 A1 ES 8304093A1
Authority
ES
Spain
Prior art keywords
tetrahydropyrimidin
diazepin
antihypertensives
ureas
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503013A
Other languages
English (en)
Other versions
ES503013A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/159,986 external-priority patent/US4466966A/en
Priority claimed from US06/159,988 external-priority patent/US4285948A/en
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of ES8304093A1 publication Critical patent/ES8304093A1/es
Publication of ES503013A0 publication Critical patent/ES503013A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/16—Nitrogen atoms not forming part of a nitro radical acylated on said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE N-(FENIL)-N - (1,4,5,6-TETRAHIDROPIRIMIDIN-2-IL) O (4,5,6,7-TETRAHIDRO-1H-1,3-DIAZEPIN-2-IL) UREAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X ES BR O CL; Y ES BR, CL O CH ; Y N VALE 0 O 1. CONSISTE EN LA REACCION DE AMIDIFICACION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE X, Y Y N TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, A TEMPERATURAS COMPRENDIDAS ENTRE -20 C Y 70 C. EL COMPUESTO OBTENIDO SE PUEDE HACER REACCIONAR CON UN ACIDO PARA OBTENER LA SAL CORRESPONDIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA IRRITACION INTESTINAL Y COMO AGENTES ANTIDIARREICOS Y ANTIHIPERTENSIVOS.
ES503013A 1980-06-16 1981-06-12 Un procedimiento para la preparacion de una n-(fenil)-n'(1,4,5,6-tetrahidropiridin-2-il) o (4,5,6,7-tetrahidro-1h-1,3- diazepin-2-il) urea Granted ES503013A0 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15998580A 1980-06-16 1980-06-16
US15998780A 1980-06-16 1980-06-16
US06/159,986 US4466966A (en) 1980-06-16 1980-06-16 N-aryl-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ureas for intestinal disorders
US06/159,988 US4285948A (en) 1980-06-16 1980-06-16 N-Aryl-N'-(1,4,5,6-tetrahydropyrimidine-2-yl)ureas as antihypertensives

Publications (2)

Publication Number Publication Date
ES8304093A1 true ES8304093A1 (es) 1983-02-16
ES503013A0 ES503013A0 (es) 1983-02-16

Family

ID=27496405

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503013A Granted ES503013A0 (es) 1980-06-16 1981-06-12 Un procedimiento para la preparacion de una n-(fenil)-n'(1,4,5,6-tetrahidropiridin-2-il) o (4,5,6,7-tetrahidro-1h-1,3- diazepin-2-il) urea

Country Status (15)

Country Link
EP (1) EP0042279B1 (es)
CA (1) CA1151167A (es)
DE (1) DE3172886D1 (es)
DK (1) DK260281A (es)
ES (1) ES503013A0 (es)
FI (1) FI811855A7 (es)
GR (1) GR74547B (es)
HK (1) HK24686A (es)
IL (1) IL63099A (es)
MY (1) MY8600520A (es)
NO (1) NO812023L (es)
NZ (1) NZ197385A (es)
PH (1) PH16725A (es)
PT (1) PT73196B (es)
YU (1) YU151781A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100342275B1 (ko) * 1993-10-21 2002-12-05 지.디. 썰 엘엘씨 산화질소신타제저해제로서유용한아미디노유도체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL267923A (es) * 1960-08-05
US4204000A (en) * 1975-03-31 1980-05-20 William H. Rorer, Inc. Anti-ulcer amidinoureas

Also Published As

Publication number Publication date
HK24686A (en) 1986-04-11
MY8600520A (en) 1986-12-31
EP0042279B1 (en) 1985-11-13
GR74547B (es) 1984-06-29
PT73196B (en) 1983-04-26
NZ197385A (en) 1984-08-24
EP0042279A3 (en) 1982-08-25
PT73196A (en) 1981-07-01
FI811855L (fi) 1981-12-17
IL63099A0 (en) 1981-09-13
DK260281A (da) 1981-12-17
NO812023L (no) 1981-12-17
YU151781A (en) 1984-02-29
ES503013A0 (es) 1983-02-16
EP0042279A2 (en) 1981-12-23
PH16725A (en) 1984-01-25
FI811855A7 (fi) 1981-12-17
IL63099A (en) 1985-03-31
DE3172886D1 (en) 1985-12-19
CA1151167A (en) 1983-08-02

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