ES8304544A1 - Procedimiento para la fabricacion de nuevos compuestos de b-lactama - Google Patents

Procedimiento para la fabricacion de nuevos compuestos de b-lactama

Info

Publication number
ES8304544A1
ES8304544A1 ES506440A ES506440A ES8304544A1 ES 8304544 A1 ES8304544 A1 ES 8304544A1 ES 506440 A ES506440 A ES 506440A ES 506440 A ES506440 A ES 506440A ES 8304544 A1 ES8304544 A1 ES 8304544A1
Authority
ES
Spain
Prior art keywords
preparation
gram
compound
denotes
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506440A
Other languages
English (en)
Other versions
ES506440A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55132994A external-priority patent/JPS5767581A/ja
Priority claimed from JP4551081A external-priority patent/JPS57159738A/ja
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Publication of ES8304544A1 publication Critical patent/ES8304544A1/es
Publication of ES506440A0 publication Critical patent/ES506440A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE ~J-LACTAMA, DE FORMULA (I), EN LA QUE R ES UN GRUPO AROMATICO; X Q Y X SON HIDROGENO O HALOGENO; Y Z PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), O UN DERIVADO REACTIVO DEL MISMO; CON UN ACIDO DE FORMULA (III), O UN DERIVADO REACTIVO DEL MISMO; FORMULAS EN LAS QUE R , X , X Y Z TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN SU CASO EN PRESENCIA DE UN AGENTE DESHIDRATANTE O CONDENSANTE, A LA TEMPERATURA AMBIENTE O INFERIOR. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
ES506440A 1980-09-26 1981-09-23 Procedimiento para la fabricacion de nuevos compuestos de b-lactama Granted ES506440A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55132994A JPS5767581A (en) 1980-09-26 1980-09-26 Beta-lactam derivative
JP4551081A JPS57159738A (en) 1981-03-30 1981-03-30 2-halomethylene-arylacetice acid derivative

Publications (2)

Publication Number Publication Date
ES8304544A1 true ES8304544A1 (es) 1983-03-01
ES506440A0 ES506440A0 (es) 1983-03-01

Family

ID=26385516

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506440A Granted ES506440A0 (es) 1980-09-26 1981-09-23 Procedimiento para la fabricacion de nuevos compuestos de b-lactama

Country Status (5)

Country Link
EP (1) EP0048954B1 (es)
CA (1) CA1178947A (es)
DE (1) DE3175755D1 (es)
ES (1) ES506440A0 (es)
PT (1) PT73735B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3037997A1 (de) * 1980-10-08 1982-05-13 Bayer Ag (beta) -lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel
CA1201431A (en) * 1981-12-17 1986-03-04 Daiei Tunemoto .beta.-LACTAM COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND INTERMEDIATE PRODUCTS FOR THE PREPARATION THEREOF
DE3300593A1 (de) * 1983-01-11 1984-07-12 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
DE3419012A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien
US5079242A (en) * 1987-03-11 1992-01-07 Pfizer Inc. Substituted 3-cephem compounds as antibacterial agents
US20110118462A1 (en) * 2009-11-18 2011-05-19 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory N-heterocyclic substituent-containing antibiotic, preparation and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA701191B (en) * 1969-03-24 1971-09-29 Syntex Corp 2-(6-substituted-2'-naphthyl)acetic acid esters and process for producing same
GB1497039A (en) * 1973-12-05 1978-01-05 Glaxo Lab Ltd Penicillins and cephalosporins

Also Published As

Publication number Publication date
EP0048954A3 (en) 1983-06-15
EP0048954B1 (en) 1986-12-30
DE3175755D1 (en) 1987-02-05
PT73735B (en) 1983-10-19
PT73735A (en) 1981-10-01
EP0048954A2 (en) 1982-04-07
CA1178947A (en) 1984-12-04
ES506440A0 (es) 1983-03-01

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