ES8304550A1 - "un procedimiento para preparar derivados de dialcohilpirazol". - Google Patents

"un procedimiento para preparar derivados de dialcohilpirazol".

Info

Publication number
ES8304550A1
ES8304550A1 ES513398A ES513398A ES8304550A1 ES 8304550 A1 ES8304550 A1 ES 8304550A1 ES 513398 A ES513398 A ES 513398A ES 513398 A ES513398 A ES 513398A ES 8304550 A1 ES8304550 A1 ES 8304550A1
Authority
ES
Spain
Prior art keywords
formula
reaction
compound
procedure
dialcohilpirazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513398A
Other languages
English (en)
Other versions
ES513398A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8304550A1 publication Critical patent/ES8304550A1/es
Publication of ES513398A0 publication Critical patent/ES513398A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE DIALCOHILPIRAZOL Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R , R Y R SON HIDROGENO O ALCOHILO C <- ; R ES ALCOHILO C <- ; A, R , R Y AR PUEDEN SER VARIOS RADICALES Y A Y A VALEN 0-6. CONSISTE EN LA REACCION DE METALACION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO TAL COMO BUTILLITIO, SEGUIDA DE LA REACCION DEL DERIVADO LITIADO ASI OBTENIDO CON UN COMPUESTO DE FORMULA ARCOZ, EN LAS QUE Z ES UN HALOGENO, ALCOXI O UN GRUPO EQUIVALENTE Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN CONDICIONES ANHIDRAS, A UNA TEMPERATURA ENTRE -60 C Y 0 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIINFLAMATORIOS, ANALGESICOS Y RELAJANTES MUSCULARES.
ES513398A 1981-06-26 1982-06-23 "un procedimiento para preparar derivados de dialcohilpirazol". Granted ES513398A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27757781A 1981-06-26 1981-06-26

Publications (2)

Publication Number Publication Date
ES8304550A1 true ES8304550A1 (es) 1983-03-01
ES513398A0 ES513398A0 (es) 1983-03-01

Family

ID=23061477

Family Applications (3)

Application Number Title Priority Date Filing Date
ES513399A Expired ES8304551A1 (es) 1981-06-26 1982-06-23 Un procedimiento para preparar derivados de dialcohilpirazol
ES513398A Granted ES513398A0 (es) 1981-06-26 1982-06-23 "un procedimiento para preparar derivados de dialcohilpirazol".
ES513375A Granted ES513375A0 (es) 1981-06-26 1982-06-23 "un procedimiento para preparar derivados de dialcohilpirazol".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES513399A Expired ES8304551A1 (es) 1981-06-26 1982-06-23 Un procedimiento para preparar derivados de dialcohilpirazol

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES513375A Granted ES513375A0 (es) 1981-06-26 1982-06-23 "un procedimiento para preparar derivados de dialcohilpirazol".

Country Status (11)

Country Link
EP (1) EP0068806A3 (es)
JP (1) JPS584771A (es)
AU (1) AU8515182A (es)
DD (1) DD202547A5 (es)
DK (1) DK282882A (es)
ES (3) ES8304551A1 (es)
FI (1) FI822260L (es)
GR (1) GR76155B (es)
IL (1) IL66109A0 (es)
NO (1) NO822100L (es)
ZA (1) ZA824468B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208555A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (3-amino-1h-pyrazol-4-yl)-arylmethanone derivatives
DE3600950A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 5-acylamido-1-aryl-pyrazole
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO2007031838A1 (en) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558605A (en) * 1969-05-14 1971-01-26 Parke Davis & Co Pyrazolo(3,4-e)(1,4)diazepin-7-(1h)-one compounds
BE735597A (en) * 1969-07-03 1970-01-05 1-aryl 3 4-opt subst 5-aminoalkanoylamino-pyrazoles
FR2100973A1 (en) * 1970-07-30 1972-03-24 Yoshitomi Pharmaceutical 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity
US3886143A (en) * 1974-01-21 1975-05-27 Parke Davis & Co Oxazolo {8 3,2-D{9 pyrazolo{8 4,3-F{9 {0 {8 1,4{9 diazepin-6(7H)-one compounds

Also Published As

Publication number Publication date
DK282882A (da) 1982-12-27
ES513399A0 (es) 1983-03-01
IL66109A0 (en) 1982-09-30
DD202547A5 (de) 1983-09-21
EP0068806A3 (en) 1983-08-10
ES8304551A1 (es) 1983-03-01
JPS584771A (ja) 1983-01-11
FI822260A7 (fi) 1982-12-27
EP0068806A2 (en) 1983-01-05
FI822260L (fi) 1982-12-27
ES8305350A1 (es) 1983-04-01
ZA824468B (en) 1983-04-27
FI822260A0 (fi) 1982-06-23
NO822100L (no) 1982-12-27
ES513375A0 (es) 1983-04-01
ES513398A0 (es) 1983-03-01
GR76155B (es) 1984-08-03
AU8515182A (en) 1983-01-06

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