ES8304566A1 - Procedimiento para la preparacion de derivados de la quino- lina. - Google Patents

Procedimiento para la preparacion de derivados de la quino- lina.

Info

Publication number
ES8304566A1
ES8304566A1 ES508618A ES508618A ES8304566A1 ES 8304566 A1 ES8304566 A1 ES 8304566A1 ES 508618 A ES508618 A ES 508618A ES 508618 A ES508618 A ES 508618A ES 8304566 A1 ES8304566 A1 ES 8304566A1
Authority
ES
Spain
Prior art keywords
alkyl
lower alkyl
optionally substituted
hydroxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508618A
Other languages
English (en)
Other versions
ES508618A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ACF Chemiefarma NV
Original Assignee
ACF Chemiefarma NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ACF Chemiefarma NV filed Critical ACF Chemiefarma NV
Publication of ES508618A0 publication Critical patent/ES508618A0/es
Publication of ES8304566A1 publication Critical patent/ES8304566A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE LA QUINOLINA, DE FORMULA GENERAL (I), EN LA CUAL A Y B SON -CH -CH -, -CHOH-CH -, O -CH -; R ES HIDROGENO, O HIDROXI; R ES ETILO O VINILO, R ES C <- ALQUILO, ALCOXI, CIANO, FENILO O BENZOILO; R ES ALQUILO INFERIOR; Y Z ES HIDROGENO, ALQUILO INFERIOR O FENILO, O UNA SAL DEL MISMO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LA CUAL R Y Z TIENEN LOS SIGNIFICADOS YA INDICADOS, EN PRESENCIA DE UN AGENTE REDUCTOR. DE APLICACION EN FARMACIA POR SU ACTIVIDAD ANTI-ESPASMODICA Y VASODILATANTE.
ES508618A 1979-11-01 1981-12-16 Procedimiento para la preparacion de derivados de la quino- lina. Expired ES8304566A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7908031A NL7908031A (nl) 1979-11-01 1979-11-01 Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.

Publications (2)

Publication Number Publication Date
ES508618A0 ES508618A0 (es) 1983-03-01
ES8304566A1 true ES8304566A1 (es) 1983-03-01

Family

ID=19834103

Family Applications (3)

Application Number Title Priority Date Filing Date
ES496901A Expired ES8204434A1 (es) 1979-11-01 1980-10-31 Procedimiento para la fabricacion de derivados de la quino- lina
ES508618A Expired ES8304566A1 (es) 1979-11-01 1981-12-16 Procedimiento para la preparacion de derivados de la quino- lina.
ES508617A Expired ES8300746A1 (es) 1979-11-01 1981-12-16 Procedimiento perfeccionado para la fabricacion de derivadosde la quinolina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES496901A Expired ES8204434A1 (es) 1979-11-01 1980-10-31 Procedimiento para la fabricacion de derivados de la quino- lina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES508617A Expired ES8300746A1 (es) 1979-11-01 1981-12-16 Procedimiento perfeccionado para la fabricacion de derivadosde la quinolina.

Country Status (12)

Country Link
US (1) US4472403A (es)
EP (1) EP0030044A1 (es)
JP (1) JPS5690085A (es)
AU (1) AU538841B2 (es)
DK (1) DK445280A (es)
ES (3) ES8204434A1 (es)
GR (1) GR70786B (es)
IL (1) IL61353A0 (es)
NL (1) NL7908031A (es)
NZ (1) NZ195357A (es)
PT (1) PT71999B (es)
ZA (1) ZA806682B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7908031A (nl) * 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
FR2495470A1 (fr) * 1980-12-05 1982-06-11 Pharmindustrie Nouveaux medicaments a base de derives de (quinolyl-4)-1 (piperidyl-4)-2 ethanol ou (quinolyl-4)-1 (piperidyl-4)-3 propanol
GB8528234D0 (en) * 1985-11-15 1985-12-18 Wyeth John & Brother Ltd Heterocyclic compounds
GB8531666D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
TW316902B (es) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
CA2318842A1 (en) * 1998-01-26 1999-07-29 Julie Dorothy Warrack Quinoline derivatives as antibacterials
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
US6376514B1 (en) * 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
FR2816618B1 (fr) 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US6767319B2 (en) 2001-06-29 2004-07-27 Medrad, Inc. Delivery methods, systems and components for use with hazardous pharmaceutical substances
GB0118238D0 (en) * 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
FR2842807A1 (fr) 2002-07-23 2004-01-30 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
EP1616587A1 (en) 2004-07-16 2006-01-18 Universität Zürich Method and device for accurate dispensing of radioactivity
EP1741712B1 (en) 2004-07-30 2011-06-15 Torrent Pharmaceuticals Ltd amorphous form of nebivolol hydrochloride and its preparation
EP2139541B1 (en) 2007-01-01 2018-04-11 Bayer Healthcare LLC Systems for integrated radiopharmaceutical generation, preparation, transportation, and administration
CN101679357A (zh) * 2007-05-09 2010-03-24 辉瑞大药厂 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途
US9056200B2 (en) 2008-06-06 2015-06-16 Bayer Medical Care Inc. Apparatus and methods for delivery of fluid injection boluses to patients and handling harmful fluids
CA2799775C (en) 2010-06-04 2020-03-24 Medrad, Inc. System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors
US9889288B2 (en) 2012-06-07 2018-02-13 Bayer Healthcare Llc Tubing connectors
US9125976B2 (en) 2012-06-07 2015-09-08 Bayer Medical Care Inc. Shield adapters
US9393441B2 (en) 2012-06-07 2016-07-19 Bayer Healthcare Llc Radiopharmaceutical delivery and tube management system
US9039592B2 (en) 2012-06-07 2015-05-26 Bayer Medical Care Inc. Radiopharmaceutical delivery device
US9433728B2 (en) 2013-03-01 2016-09-06 Bayer Healthcare Llc Valveless pharmaceutical infusion system

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH559181A5 (es) * 1968-07-02 1975-02-28 Hoffmann La Roche
GB1280202A (en) * 1968-07-02 1972-07-05 Hoffmann La Roche Quinoline derivatives
CH533123A (de) * 1968-07-02 1973-01-31 Hoffmann La Roche Verfahren zur Herstellung von Chinolinderivaten
GB1295539A (es) * 1970-05-06 1972-11-08
FR2177511A1 (en) * 1972-03-28 1973-11-09 Omnium Chimique Sa Quinolyl pipiridylethyl ketones - with vasodilatory and antispasmodic activity
GB1434724A (en) * 1972-04-17 1976-05-05 Rech Et Dapplications Scient S Spasmolytic medicines comprising a vidiquil derivative
GB1441244A (en) * 1972-11-17 1976-06-30 Rech Et Dapplications Scient S Derivatives of quinoline and method of preparing the same
FR2213055B2 (es) * 1973-01-08 1976-07-16 Sogeras
US3953453A (en) * 1973-12-07 1976-04-27 Hoffmann-La Roche Inc. Trifluoromethyl substituted analogs of quinine and quinidine
PT66682B (pt) * 1976-06-18 1978-11-15 Ind Biolog Francaise /(quinolyl-4)-propyl-1/-4 piperidines leur preparation et leur utilisation comme medicaments /(quinolyl-4)-propyl/-4 piperidines leur preparation et leur utilisation comme medicaments
FR2432518A2 (fr) * 1978-08-03 1980-02-29 Pharmindustrie Derives de la ((quinolyl-4)-3 propyl-1)-4 piperidine utilisables comme medicaments
GR69926B (es) * 1978-03-23 1982-07-21 Pharmindustrie
NL7908030A (nl) * 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
NL7908031A (nl) * 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
FR2471981A1 (fr) * 1979-12-21 1981-06-26 Pharmindustrie Nouveaux derives de la (piperidyl-4)-2 (quinolyl-4)-1 ethanone, produits intermediaires et procedes pour leur preparation, et leur utilisation comme medicaments

Also Published As

Publication number Publication date
EP0030044A1 (en) 1981-06-10
AU538841B2 (en) 1984-08-30
PT71999B (en) 1981-08-31
ES508617A0 (es) 1982-11-01
ZA806682B (en) 1981-10-28
GR70786B (es) 1983-01-23
ES8300746A1 (es) 1982-11-01
ES496901A0 (es) 1982-05-01
ES508618A0 (es) 1983-03-01
AU6360980A (en) 1981-05-07
PT71999A (en) 1980-11-01
NL7908031A (nl) 1981-06-01
DK445280A (da) 1981-05-02
ES8204434A1 (es) 1982-05-01
IL61353A0 (en) 1980-12-31
NZ195357A (en) 1984-07-06
JPS5690085A (en) 1981-07-21
US4472403A (en) 1984-09-18

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