ES8304571A1 - "procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas". - Google Patents
"procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas".Info
- Publication number
- ES8304571A1 ES8304571A1 ES512846A ES512846A ES8304571A1 ES 8304571 A1 ES8304571 A1 ES 8304571A1 ES 512846 A ES512846 A ES 512846A ES 512846 A ES512846 A ES 512846A ES 8304571 A1 ES8304571 A1 ES 8304571A1
- Authority
- ES
- Spain
- Prior art keywords
- tetrahydropyrazolo
- diazepin
- pyrido
- ones
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title 2
- FOLVLVWVFLSTFO-UHFFFAOYSA-N 2,5,6,9,14-pentazatricyclo[8.4.0.03,7]tetradeca-1(10),3(7),4,11,13-pentaen-8-one Chemical class O=C1NC2=CC=CN=C2NC2=C1NN=C2 FOLVLVWVFLSTFO-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 229940125716 antipyretic agent Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 1,4,9,10-TETRAHIDRO-PIRAZOLO 4,3-E PIRIDO 3,2-B 1,4 DIAZEPIN- 10-ONAS, DE FORMULA (I) EN LA QUE R ES HIDROGENO O ALCOHILO C <- ; R ES ALCOHILO C <- ; R ES HIDROGENO O ALCOHILO C <- ; Y R ES HIDROGENO O ALCOHILO C <- . CONSISTE EN LA REACCION DE CICLIZACION DE UN N-(2-HALOGENO-3-PIRIDINIL)-4-AMINO-1H-PIRAZOL-5-CARBOXAMIDA, DE FORMULA (II), EN LA QUE R -R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y HAL ES UN ATOMO DE HALOGENO. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE, EVENTUALMENTE EN PRESENCIA DE UN ACIDO MINERAL, COMO CATALIZADOR, A UNA TEMPERATURA ENTRE 80 C Y 200 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO ANALGESICO, ANTIFLOGISTICO Y ANTIPIRETICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813122670 DE3122670A1 (de) | 1981-06-06 | 1981-06-06 | "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen" |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8304571A1 true ES8304571A1 (es) | 1983-03-01 |
| ES512846A0 ES512846A0 (es) | 1983-03-01 |
Family
ID=6134176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES512846A Granted ES512846A0 (es) | 1981-06-06 | 1982-06-04 | "procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas". |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4381303A (es) |
| EP (1) | EP0066774B1 (es) |
| JP (1) | JPS57212182A (es) |
| KR (1) | KR880001719B1 (es) |
| AR (1) | AR229124A1 (es) |
| AT (1) | ATE10744T1 (es) |
| AU (1) | AU552765B2 (es) |
| CA (1) | CA1167440A (es) |
| CS (1) | CS226743B2 (es) |
| DD (1) | DD202574A5 (es) |
| DE (2) | DE3122670A1 (es) |
| DK (1) | DK253382A (es) |
| ES (1) | ES512846A0 (es) |
| FI (1) | FI71560C (es) |
| GB (1) | GB2117755B (es) |
| GR (1) | GR76438B (es) |
| HU (1) | HU186067B (es) |
| IE (1) | IE53067B1 (es) |
| IL (1) | IL65977A (es) |
| NO (1) | NO158063C (es) |
| NZ (1) | NZ200859A (es) |
| PH (1) | PH17719A (es) |
| PL (1) | PL135845B1 (es) |
| PT (1) | PT75016B (es) |
| SU (1) | SU1103795A3 (es) |
| YU (1) | YU118282A (es) |
| ZA (1) | ZA823919B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3643666A1 (de) * | 1986-12-20 | 1988-06-30 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4749788A (en) * | 1987-04-13 | 1988-06-07 | A. H. Robins Company, Incorporated | Process for the preparation of aryl-pyrido(1,4) benzodiazepines |
| US5366972A (en) * | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| DK0410148T3 (da) * | 1989-06-28 | 1994-08-08 | Boehringer Ingelheim Pharma | Hidtil ukendte 5,11-dihydro-6H-dipyrido(3,2-b:2,3-e)-(1,4)diazepin-6-oner og -thioner og deres anvendelse til forebyggelse eller behandling af AIDS |
| CA2052946A1 (en) * | 1990-10-19 | 1992-04-20 | Karl G. Grozinger | Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines |
| ATE177099T1 (de) * | 1993-12-29 | 1999-03-15 | Pfizer | Diazabicyclische neurokinin antagonisten |
| CA2183571A1 (en) * | 1994-02-18 | 1995-08-24 | Karl D. Hargrave | 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection |
| ES2137113B1 (es) | 1997-07-29 | 2000-09-16 | Almirall Prodesfarma Sa | Nuevos derivados de triazolo-piridazinas heterociclicos. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450694A (en) * | 1966-02-23 | 1969-06-17 | Abbott Lab | Substituted benzoxazepines and benzothiazepines |
| DE2707269A1 (de) * | 1977-02-19 | 1978-08-24 | Hoechst Ag | Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung |
| CA1154762A (en) * | 1979-08-03 | 1983-10-04 | Georg Rainer | Substituted tetraazatricyclic compounds, a process for their preparation, their use and medicaments containing them |
-
1981
- 1981-06-06 DE DE19813122670 patent/DE3122670A1/de not_active Withdrawn
-
1982
- 1982-05-13 US US06/377,911 patent/US4381303A/en not_active Expired - Fee Related
- 1982-05-25 SU SU823441915A patent/SU1103795A3/ru active
- 1982-05-25 AT AT82104549T patent/ATE10744T1/de not_active IP Right Cessation
- 1982-05-25 DE DE8282104549T patent/DE3261530D1/de not_active Expired
- 1982-05-25 EP EP82104549A patent/EP0066774B1/de not_active Expired
- 1982-06-01 AR AR289564A patent/AR229124A1/es active
- 1982-06-02 GR GR68322A patent/GR76438B/el unknown
- 1982-06-03 YU YU01182/82A patent/YU118282A/xx unknown
- 1982-06-03 CS CS824137A patent/CS226743B2/cs unknown
- 1982-06-03 PL PL1982236742A patent/PL135845B1/pl unknown
- 1982-06-03 DD DD82240437A patent/DD202574A5/de unknown
- 1982-06-03 KR KR8202494A patent/KR880001719B1/ko not_active Expired
- 1982-06-04 IE IE1350/82A patent/IE53067B1/en unknown
- 1982-06-04 PT PT75016A patent/PT75016B/pt unknown
- 1982-06-04 IL IL65977A patent/IL65977A/xx unknown
- 1982-06-04 CA CA000404541A patent/CA1167440A/en not_active Expired
- 1982-06-04 JP JP57096080A patent/JPS57212182A/ja active Pending
- 1982-06-04 ZA ZA823919A patent/ZA823919B/xx unknown
- 1982-06-04 NO NO821882A patent/NO158063C/no unknown
- 1982-06-04 GB GB08216381A patent/GB2117755B/en not_active Expired
- 1982-06-04 HU HU821823A patent/HU186067B/hu unknown
- 1982-06-04 PH PH27402A patent/PH17719A/en unknown
- 1982-06-04 FI FI821992A patent/FI71560C/fi not_active IP Right Cessation
- 1982-06-04 NZ NZ200859A patent/NZ200859A/en unknown
- 1982-06-04 AU AU84605/82A patent/AU552765B2/en not_active Ceased
- 1982-06-04 ES ES512846A patent/ES512846A0/es active Granted
- 1982-06-04 DK DK253382A patent/DK253382A/da not_active Application Discontinuation
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