ES8304578A1 - PROCEDURE FOR PREPARING ERGOLINE DERIVATIVES. - Google Patents

PROCEDURE FOR PREPARING ERGOLINE DERIVATIVES.

Info

Publication number
ES8304578A1
ES8304578A1 ES509825A ES509825A ES8304578A1 ES 8304578 A1 ES8304578 A1 ES 8304578A1 ES 509825 A ES509825 A ES 509825A ES 509825 A ES509825 A ES 509825A ES 8304578 A1 ES8304578 A1 ES 8304578A1
Authority
ES
Spain
Prior art keywords
hydrogen
procedure
formula
ergoline derivatives
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509825A
Other languages
Spanish (es)
Other versions
ES509825A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH121081A external-priority patent/CH645894A5/en
Priority claimed from CH121181A external-priority patent/CH645895A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8304578A1 publication Critical patent/ES8304578A1/en
Publication of ES509825A0 publication Critical patent/ES509825A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE LA ERGOLINA, DE FORMULA (I), EN LA QUE R REPRESENTA HIDROGENO, ALQUILO (C -C ) O UN PRECURSOR DEL MISMO; R REPRESENTA ALQUILO (C -C ); R Y R SIGNIFICAN, INDEPENDIENTEMENTE UNO DE OTRO, HIDROGENO O ALQUILO (C -C ); A Y B REPRESENTAN CADA UNO DE ELLOS HIDROGENO. CONSISTE EN OXIDAR UN COMPUESTO DE FORMULA (II), EN LA QUE R , R , R , R , A Y B TIENEN LOS MISMOS SIGNIFICADOS YA INDICADOS, Y R REPRESENTA HIDROGENO O HIDROXI, PARA PRODUCIR UN COMPUESTO DE FORMULA (I), EN EL QUE R SIGNIFICA HIDROGENO. DE APLICACION EN TRATAMIENTOS CLINICOS, ESPECIALMENTE IDONEA PARA EL TRATAMIENTO DE JAQUECAS, DE LA NEURALGIA TRIGEMINAL, DE ALERGIAS GENERALES Y DE DESORDENES INFLAMATORIOS.PROCEDURE FOR PREPARING ERGOLINE DERIVATIVES, OF FORMULA (I), IN WHICH R REPRESENTS HYDROGEN, ALKYL (C -C ) OR A PRECURSOR THEREOF; R REPRESENTS RENT (C -C ); R AND R MEAN, INDEPENDENTLY ONE OF THE OTHER, HYDROGEN OR ALKYL (C -C ); A AND B EACH REPRESENT HYDROGEN. IT CONSISTS OF OXIDIZING A COMPOUND OF FORMULA (II), IN WHICH R , R , R , R , A AND B HAVE THE SAME MEANINGS ALREADY INDICATED, AND R REPRESENTS HYDROGEN OR HYDROXY, TO PRODUCE A COMPOUND OF FORMULA (I), IN WHICH R MEANS HYDROGEN. FOR APPLICATION IN CLINICAL TREATMENTS, ESPECIALLY SUITABLE FOR THE TREATMENT OF HEADACHES, TRIGEMINAL NEURALGIA, GENERAL ALLERGIES AND INFLAMMATORY DISORDERS.

ES509825A 1981-02-24 1982-02-23 PROCEDURE FOR PREPARING ERGOLINE DERIVATIVES. Granted ES509825A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH121081A CH645894A5 (en) 1981-02-24 1981-02-24 Ergoline derivatives, their preparation and use
CH121181A CH645895A5 (en) 1981-02-24 1981-02-24 Ergoline derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
ES8304578A1 true ES8304578A1 (en) 1983-03-01
ES509825A0 ES509825A0 (en) 1983-03-01

Family

ID=25687002

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509825A Granted ES509825A0 (en) 1981-02-24 1982-02-23 PROCEDURE FOR PREPARING ERGOLINE DERIVATIVES.

Country Status (16)

Country Link
AU (1) AU8068282A (en)
CA (1) CA1178582A (en)
DE (1) DE3205169A1 (en)
DK (1) DK77082A (en)
ES (1) ES509825A0 (en)
FI (1) FI820526L (en)
FR (1) FR2500454A1 (en)
GB (1) GB2093452B (en)
HU (1) HU187650B (en)
IL (1) IL65074A0 (en)
NL (1) NL8200694A (en)
NZ (1) NZ199795A (en)
PH (1) PH17494A (en)
PT (1) PT74468B (en)
SE (1) SE8201098L (en)
WO (1) WO1982002892A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309493A1 (en) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen NEW ERGOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT
DE3402392A1 (en) * 1984-01-25 1985-08-01 Sandoz-Patent-GmbH, 7850 Lörrach NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND THEIR USE
DE3445784A1 (en) * 1984-12-13 1986-06-26 Schering AG, Berlin und Bergkamen, 1000 Berlin METHOD FOR PRODUCING ERGOLIN DERIVATIVES
DE3528584A1 (en) * 1985-08-06 1987-02-19 Schering Ag NEW 1-ALKYL-ERGOLIN-THIOURINE DERIVATIVES
DE3528576A1 (en) * 1985-08-06 1987-02-19 Schering Ag METHOD FOR THE PRODUCTION OF ERGOLIN THIOUROS
DE3533672A1 (en) * 1985-09-19 1987-03-26 Schering Ag NEW 12- AND 13-SUBSTITUTED ERGOL DERIVATIVES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646046A (en) * 1968-03-07 1972-02-29 Farmaceutici Italia 1 6-dimethyl-10alpha-ergoline derivatives
DK140596B (en) * 1971-05-19 1979-10-08 Sandoz Ag Analogous process for the preparation of 8beta- (ureidomethyl) -ergolene derivatives.
CH628049A5 (en) * 1977-03-25 1982-02-15 Sandoz Ag Process for the preparation of ergolene derivatives
FR2421176A1 (en) * 1978-03-29 1979-10-26 Sandoz Sa NEW DERIVATIVES OF RYE ERGOT, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
AU8068282A (en) 1982-09-02
PT74468B (en) 1984-08-01
PH17494A (en) 1984-09-04
FI820526A7 (en) 1982-08-25
FR2500454B1 (en) 1984-11-09
DE3205169A1 (en) 1982-10-14
GB2093452B (en) 1984-11-07
ES509825A0 (en) 1983-03-01
PT74468A (en) 1982-03-01
WO1982002892A1 (en) 1982-09-02
IL65074A0 (en) 1982-04-30
NZ199795A (en) 1985-08-30
DK77082A (en) 1982-08-25
GB2093452A (en) 1982-09-02
HU187650B (en) 1986-02-28
FI820526L (en) 1982-08-25
CA1178582A (en) 1984-11-27
FR2500454A1 (en) 1982-08-27
SE8201098L (en) 1982-08-25
NL8200694A (en) 1982-09-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010402