ES8304912A1 - Procedimiento para la preparacion de un acido graso marcado con yodo radioactivo. - Google Patents

Procedimiento para la preparacion de un acido graso marcado con yodo radioactivo.

Info

Publication number
ES8304912A1
ES8304912A1 ES513640A ES513640A ES8304912A1 ES 8304912 A1 ES8304912 A1 ES 8304912A1 ES 513640 A ES513640 A ES 513640A ES 513640 A ES513640 A ES 513640A ES 8304912 A1 ES8304912 A1 ES 8304912A1
Authority
ES
Spain
Prior art keywords
preparation
fatty acid
radioactive iodine
extemporized
carrying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513640A
Other languages
English (en)
Other versions
ES513640A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Publication of ES513640A0 publication Critical patent/ES513640A0/es
Publication of ES8304912A1 publication Critical patent/ES8304912A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
    • C07C33/042—Acyclic alcohols with carbon-to-carbon triple bonds with only one triple bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN ACIDO GRASO MARCADO CON YODO RADIACTIVO. CONSISTE EN LA REACCION DE UN ACIDO GRASO BROMADO O YODADO EN POSICION OMEGA, DISUELTO EN UNA CETONA MISCIBLE CON AGUA, CON YODURO RADIACTIVO EN ESTADO SECO O CON UNA DISOLUCION ACUOSA DE YODURO RADIACTIVO, EN PRESENCIA DE UN YODURO ARRASTRADOR, TAL COMO YODURO SODICO. DESPUES DE LA REACCION DE INTERCAMBIO SE EVAPORA LA CETONA Y SE AÑADE UNA DISOLUCION TAMPON, QUE FORMA UNA SUSPENSION COLOIDAL QUE SE DISUELVE EN UN LIQUIDO FISIOLOGICAMENTE COMPATIBLE. ESTOS ACIDOS GRASOS MARCADOS TIENEN APLICACIONES PARA ESTUDIAR LOS TRASTORNOS DEL METABOLISMO CARDIACO POR ENCINTIGRAFIA.
ES513640A 1981-07-02 1982-07-01 Procedimiento para la preparacion de un acido graso marcado con yodo radioactivo. Expired ES8304912A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8113039A FR2508902B1 (fr) 1981-07-02 1981-07-02 Procede de preparation extemporanee d'un acide gras injectable, marque a l'iode radioactif et preparation de derives iodes utilisables pour la mise en oeuvre de ce procede

Publications (2)

Publication Number Publication Date
ES513640A0 ES513640A0 (es) 1983-03-16
ES8304912A1 true ES8304912A1 (es) 1983-03-16

Family

ID=9260121

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513640A Expired ES8304912A1 (es) 1981-07-02 1982-07-01 Procedimiento para la preparacion de un acido graso marcado con yodo radioactivo.

Country Status (9)

Country Link
US (1) US4476106A (es)
EP (1) EP0069648B1 (es)
JP (1) JPS5859926A (es)
AT (1) ATE17940T1 (es)
CA (1) CA1198737A (es)
DK (1) DK293082A (es)
ES (1) ES8304912A1 (es)
FR (1) FR2508902B1 (es)
NO (1) NO162612C (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2947500C2 (de) * 1979-11-24 1984-05-10 Dutschka, Klaus, 4300 Essen Radiojodierte ω -Phenylfettsäuren, ihre Herstellung und deren Verwendung zur szintigraphischen Untersuchung des Herzmuskels und der Leber
US4649039A (en) * 1984-07-03 1987-03-10 E. I. Du Pont De Nemours And Company Radiolabeling of methionine-containing proteins and peptides
US4764358A (en) * 1985-04-30 1988-08-16 The United States Of America As Represented By The United States Department Of Energy Radiolabeled dimethyl branched long chain fatty acid for heart imaging
JP2715240B2 (ja) * 1993-05-18 1998-02-18 株式会社第一ラジオアイソトープ研究所 放射性ヨウ素標識脂肪酸−シクロデキストリン複合体およびこれを含有するイメージング剤
FR2726765B1 (fr) * 1994-11-14 1996-12-20 Cis Bio Int Compositions radiopharmaceutiques comprenant un complexe d'inclusion d'une cyclodextrine et d'un acide gras radiohalogene
DE69636881T2 (de) * 1995-12-01 2007-09-20 Molecular Insight Pharmaceuticals, Inc., Cambridge Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung
EP1384706A1 (de) * 2002-07-24 2004-01-28 Degussa AG Verfahren zur Monoalkylierung C-H-acider Methylengruppen
DE102010010666A1 (de) * 2010-03-01 2011-09-01 Sven Reske Diagnose und Therapie von Krebserkrankungen mittels Fettsäuren
CN113087623A (zh) * 2021-04-13 2021-07-09 苏州昊帆生物股份有限公司 一种8-溴辛酸乙酯的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2810696C3 (de) * 1978-03-11 1982-02-25 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur Gewinnung von ω-↑123↑J-Hexadecansäure oder ω↑123↑J-Heptadecansäure und deren Verwendung als Radiopharmaka
DE2828623C2 (de) * 1978-06-29 1983-11-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Mit radioaktivem Flour markierte C↓1↓↓6↓-bis C↓1↓↓8↓- Fettsäuren, ein Verfahren zu ihrer Herstellung sowie deren Verwendung
DE2914089C2 (de) * 1979-04-07 1982-02-11 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur Herstellung von ω-↑123↑J-markierten Fettsäuren
DE2947500C2 (de) * 1979-11-24 1984-05-10 Dutschka, Klaus, 4300 Essen Radiojodierte ω -Phenylfettsäuren, ihre Herstellung und deren Verwendung zur szintigraphischen Untersuchung des Herzmuskels und der Leber
DE3127239A1 (de) * 1981-07-10 1983-01-20 Hoechst Ag, 6000 Frankfurt Quartaere n-alkyl-n,n',n'-polyoxyalkyl-(alpha),(omega)-diaminoalkylenfettsaeureester, verfahren zu deren herstellung und deren verwendung

Also Published As

Publication number Publication date
ES513640A0 (es) 1983-03-16
CA1198737A (en) 1985-12-31
NO162612C (no) 1990-01-24
FR2508902A1 (fr) 1983-01-07
EP0069648A1 (fr) 1983-01-12
US4476106A (en) 1984-10-09
DK293082A (da) 1983-01-03
NO162612B (no) 1989-10-16
NO822147L (no) 1983-01-03
JPH0365333B2 (es) 1991-10-11
FR2508902B1 (fr) 1985-09-06
JPS5859926A (ja) 1983-04-09
EP0069648B1 (fr) 1986-02-12
ATE17940T1 (de) 1986-02-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612