ES8305313A1 - Procedimiento para la preparacion de un metil amino-acetonitrilo-2-fluorado que es un intermediario util en la prepara- cion de compuestos farmaceuticamente activo. - Google Patents

Procedimiento para la preparacion de un metil amino-acetonitrilo-2-fluorado que es un intermediario util en la prepara- cion de compuestos farmaceuticamente activo.

Info

Publication number
ES8305313A1
ES8305313A1 ES504882A ES504882A ES8305313A1 ES 8305313 A1 ES8305313 A1 ES 8305313A1 ES 504882 A ES504882 A ES 504882A ES 504882 A ES504882 A ES 504882A ES 8305313 A1 ES8305313 A1 ES 8305313A1
Authority
ES
Spain
Prior art keywords
preparation
cyanide
aminoacetonitrile derivatives
fluorinated methyl
aminoacetonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504882A
Other languages
English (en)
Other versions
ES504882A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrell Toraude et Cie
Original Assignee
Merrell Toraude et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie
Publication of ES8305313A1 publication Critical patent/ES8305313A1/es
Publication of ES504882A0 publication Critical patent/ES504882A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1782—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN METIL AMINO-ACETONITRILO 2-FLUORADO, DE FORMULA GENERAL (I), EN LA QUE R REPRESENTA UN GRUPO ORGANICO; Y P SIGNIFICA 1 O 2. CONSISTE EN HACER REACCIONAR UN HALURO DE MAGNESIO DE CETIMINA, DE FORMULA GENERAL (II), EN LA QUE R Y P TIENEN LOS SIGNIFICADOS YA INDICADOS; Y Z REPRESENTA BROMO, CLORO O YODO, CON CIANURO DE HIDROGENO O DE AMONIO O CON UN CIANURO DE METAL ALCALINO, EN PRESENCIA DE UNA FUENTE DE PROTONES. DE APLICACION EN EL TRATAMIENTO DE ALERGIAS Y DE ESTADOS DE HIPERTENSION GASTRICA.
ES504882A 1980-08-23 1981-08-21 Procedimiento para la preparacion de un metil amino-acetonitrilo-2-fluorado que es un intermediario util en la prepara- cion de compuestos farmaceuticamente activo. Granted ES504882A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8027503 1980-08-23
US21049980A 1980-11-26 1980-11-26

Publications (2)

Publication Number Publication Date
ES8305313A1 true ES8305313A1 (es) 1983-04-16
ES504882A0 ES504882A0 (es) 1983-04-16

Family

ID=26276675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504882A Granted ES504882A0 (es) 1980-08-23 1981-08-21 Procedimiento para la preparacion de un metil amino-acetonitrilo-2-fluorado que es un intermediario util en la prepara- cion de compuestos farmaceuticamente activo.

Country Status (11)

Country Link
EP (1) EP0046710B1 (es)
AU (1) AU542144B2 (es)
CA (1) CA1164479A (es)
DE (1) DE3164179D1 (es)
DK (1) DK371981A (es)
ES (1) ES504882A0 (es)
GB (1) GB2083031B (es)
IE (1) IE51512B1 (es)
NO (1) NO151460C (es)
NZ (1) NZ198118A (es)
PH (1) PH18010A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE54326B1 (en) * 1981-08-19 1989-08-30 Merrell Dow France Decarboxylase-inhibiting fluorinated alkane diamine derivatives
DE3474815D1 (en) * 1983-03-28 1988-12-01 American Cyanamid Co Novel process for the preparation of aminonitriles useful for the preparation of herbicides
US4847401A (en) * 1985-12-31 1989-07-11 Merrell Dow Pharmaceuticals Inc. Continuous large-scale production of ethyl 2,2-difluoro-4-pentenoate and 2-fluorinated methyl aminoacetonitriles by use of a flow reactor
US6187296B1 (en) 1998-01-23 2001-02-13 The Board Of Regents Of The University Of Oklahoma Lysine decarboxylase inhibitors for the prevention and treatment of periodontal disease
US6103220A (en) * 1998-01-23 2000-08-15 Levine; Martin Lysine decarboxylase inhibitors for the prevention and treatment of periodontal disease
US20220226269A1 (en) * 2019-06-12 2022-07-21 President And Fellows Of Harvard College Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422132A (en) * 1966-03-15 1969-01-14 Du Pont Preparation of primary alpha-aminonitriles

Also Published As

Publication number Publication date
NO151460C (no) 1985-04-17
GB2083031A (en) 1982-03-17
AU542144B2 (en) 1985-02-07
NZ198118A (en) 1985-02-28
GB2083031B (en) 1984-04-18
DE3164179D1 (de) 1984-07-19
PH18010A (en) 1985-02-28
CA1164479A (en) 1984-03-27
DK371981A (da) 1982-02-24
NO151460B (no) 1985-01-02
NO812842L (no) 1982-02-24
IE51512B1 (en) 1987-01-07
EP0046710B1 (en) 1984-06-13
EP0046710A1 (en) 1982-03-03
IE811926L (en) 1982-02-23
AU7443181A (en) 1982-03-04
ES504882A0 (es) 1983-04-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401