ES8306020A1 - Phenylethanolamine derivative - Google Patents
Phenylethanolamine derivativeInfo
- Publication number
- ES8306020A1 ES8306020A1 ES514425A ES514425A ES8306020A1 ES 8306020 A1 ES8306020 A1 ES 8306020A1 ES 514425 A ES514425 A ES 514425A ES 514425 A ES514425 A ES 514425A ES 8306020 A1 ES8306020 A1 ES 8306020A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- lower alkyl
- benzyl
- adrenaline
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical class NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- PIJVXPYKRQJBON-UHFFFAOYSA-N 2-[4-(4-methoxyphenyl)butan-2-ylamino]-1-(4-methyl-3-methylsulfanylphenyl)ethanol Chemical compound C1=CC(OC)=CC=C1CCC(C)NCC(O)C1=CC=C(C)C(SC)=C1 PIJVXPYKRQJBON-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000003782 Raynaud disease Diseases 0.000 abstract 1
- 208000012322 Raynaud phenomenon Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003944 halohydrins Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:The phenylethanolamine derivative of formula I (R1 is lower alkyl R2 is H or lower alkyl R3 is OH, lower alkyl or lower alkoxy X is O or methylene m is integer 1-3 n is integer 0-2). EXAMPLE:alpha-[[ 3-( 4-Methoxyphenyl )-1-methylpropylamino ]methyl ]-4-methyl-3- methylthiobenzene-methanol. USE:A hypotensor having low side effects and remedy for peripheral disorder such as Raynaud's disease, and stenocardia. In has both alpha-adrenaline-blocking activity and beta-adrenaline-blocking activity. PROCESS:The compound of formula I is prepared by reacting a halohydrin of formula II1 (Hal is halogen) or an epoxide of formula II2 with an amide of formula III (Z is H or benzyl when n is 0 or 1, Z is H), or by removing the benzyl group when Z of the resulted compound of formula I1 is benzyl
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10417580A JPS5728040A (en) | 1980-07-29 | 1980-07-29 | Phenylethanolamine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8306020A1 true ES8306020A1 (en) | 1983-05-01 |
| ES514425A0 ES514425A0 (en) | 1983-05-01 |
Family
ID=14373678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES514425A Granted ES514425A0 (en) | 1980-07-29 | 1982-07-27 | A PROCEDURE FOR THE PREPARATION OF A FENETILAMINA DERIVATIVE. |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5728040A (en) |
| ES (1) | ES514425A0 (en) |
-
1980
- 1980-07-29 JP JP10417580A patent/JPS5728040A/en active Pending
-
1982
- 1982-07-27 ES ES514425A patent/ES514425A0/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5728040A (en) | 1982-02-15 |
| ES514425A0 (en) | 1983-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |