ES8306093A1 - Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos. - Google Patents

Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos.

Info

Publication number
ES8306093A1
ES8306093A1 ES508670A ES508670A ES8306093A1 ES 8306093 A1 ES8306093 A1 ES 8306093A1 ES 508670 A ES508670 A ES 508670A ES 508670 A ES508670 A ES 508670A ES 8306093 A1 ES8306093 A1 ES 8306093A1
Authority
ES
Spain
Prior art keywords
derivatives
aminoalcoyl
cyclic
pharmaceutically active
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508670A
Other languages
English (en)
Other versions
ES508670A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8027252A external-priority patent/FR2496653A1/fr
Priority claimed from FR8123304A external-priority patent/FR2518087A2/fr
Application filed by Delalande SA filed Critical Delalande SA
Publication of ES8306093A1 publication Critical patent/ES8306093A1/es
Publication of ES508670A0 publication Critical patent/ES508670A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS AMINOACIL HETEROCICLICOS, DE FORMULA GENERAL (I), EN LA QUE A REPRESENTA NITROGENO O CH; R REPRESENTA UN NUCLEO FENILO U ORTOFLUOROFENILO; N ES 1, 2 O 3; R Y R JUNTAMENTE CON N REPRESENTAN METILAMINO, PIRROLIDINO, PIPERIDINO O MORFOLINO; Y R REPRESENTA HIDROGENO, HALOGENO O UN GRUPO ALQUILO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN DONDE A, R, N Y R TIENEN EL SIGNIFICADO YA INDICADO; Y M<S REPRESENTA EL GRUPO MESILO, CON AMINAS DE FORMULA (III), EN DONDE R Y R TIENEN LOS SIGNIFICADOS YA INDICADOS. DE APLICACION COMO ANALGESICOS Y ANTIDEPRESORES.
ES508670A 1980-12-22 1981-12-21 Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos. Granted ES508670A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8027252A FR2496653A1 (fr) 1980-12-22 1980-12-22 Nouveaux derives aminoalcoyl heterocycliques, leurs procedes de preparation et leur application en therapeutique
FR8123304A FR2518087A2 (en) 1981-12-14 1981-12-14 Aminoalkyl di:hydro-naphthalene, isoquinoline and benzoxazepine cpds. - useful as analgesics and antidepressants

Publications (2)

Publication Number Publication Date
ES8306093A1 true ES8306093A1 (es) 1983-06-01
ES508670A0 ES508670A0 (es) 1983-06-01

Family

ID=26222136

Family Applications (3)

Application Number Title Priority Date Filing Date
ES508670A Granted ES508670A0 (es) 1980-12-22 1981-12-21 Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos.
ES518692A Granted ES518692A0 (es) 1980-12-22 1982-12-16 Metodo de preparacion de derivados farmaceuticamente activosaminoalcoil heterociclicos.
ES518693A Granted ES518693A0 (es) 1980-12-22 1982-12-16 Metodo de preparar compuestos aminoalcoil heterociclicos de de actividad farmaceutica.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES518692A Granted ES518692A0 (es) 1980-12-22 1982-12-16 Metodo de preparacion de derivados farmaceuticamente activosaminoalcoil heterociclicos.
ES518693A Granted ES518693A0 (es) 1980-12-22 1982-12-16 Metodo de preparar compuestos aminoalcoil heterociclicos de de actividad farmaceutica.

Country Status (11)

Country Link
US (3) US4386090A (es)
AU (1) AU7875781A (es)
CA (1) CA1181748A (es)
DE (1) DE3150876A1 (es)
ES (3) ES508670A0 (es)
GB (2) GB2091250B (es)
GR (1) GR78081B (es)
IT (1) IT1168074B (es)
LU (1) LU83850A1 (es)
NL (1) NL8105791A (es)
SE (1) SE8107537L (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
FR2544718B1 (fr) * 1983-04-21 1985-12-20 Hexachimie Diniflumate d'ester morpholinoethylique d'acide niflumique, preparation, utilisation en therapeutique comme analgesique et anti-inflammatoire
US4745222A (en) * 1983-05-25 1988-05-17 Merrell Dow Pharmaceuticals Inc. Novel aryloxycycloalkanolaminoalkylene aryl ketones
DE3413897A1 (de) * 1984-04-13 1985-10-17 Bayer Ag, 5090 Leverkusen (beta)-naphthylalkylamine
EP0261842B1 (en) * 1986-09-17 1990-11-22 Dr. Lo. Zambeletti S.p.A. N1-acylated-(1-(phenyl or benzyl))-1,2-ethylene diamines
US5561152A (en) * 1987-08-14 1996-10-01 Merrell Pharmaceuticals Inc. Antidepressants
ZA885824B (en) * 1987-08-14 1989-04-26 Merrell Dow Pharma Novel antidepressants
US5149714A (en) * 1987-08-14 1992-09-22 Merrell Dow Pharmaceuticals Inc. Antidepressants
US5229414A (en) * 1988-01-21 1993-07-20 Imperial Chemical Industries Plc Diamine compounds
DE68918832T2 (de) * 1988-12-28 1995-02-09 Suntory Ltd Benzoxazepinderivate.
US5948820A (en) * 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
IT1303737B1 (it) * 1998-11-11 2001-02-23 Smithkline Beecham Spa Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1.
WO2002057215A2 (en) * 2001-01-16 2002-07-25 Theravance, Inc. Sodium channel modulators
CA2450475A1 (en) * 2001-06-20 2003-01-03 Linda Brockunier Dipeptidyl peptidase inhibitors for the treatment of diabetes
AU2002344820B2 (en) * 2001-06-20 2006-12-14 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
MXPA04006709A (es) * 2002-01-11 2004-10-04 Sankyo Co Derivados de aminoalcohol o derivados de acido fosfonico y composiciones farmaceuticas que los contienen.
WO2004007468A1 (en) * 2002-07-15 2004-01-22 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
WO2004032836A2 (en) * 2002-10-07 2004-04-22 Merck & Co., Inc. Antidiabetic beta-amino heterocylcic dipeptidyl peptidase inhibitors
JP4413863B2 (ja) * 2002-11-07 2010-02-10 メルク エンド カムパニー インコーポレーテッド 糖尿病の治療又は予防のためのジペチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
JP2006510630A (ja) * 2002-12-04 2006-03-30 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
EP1583534A4 (en) * 2002-12-20 2007-08-29 Merck & Co Inc 3-AMINO-4-PHENYLBUTANIC ACID DERIVATIVES AS DIPEPTIDYL-PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
CA2512546A1 (en) * 2003-01-17 2004-08-05 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP2006516573A (ja) * 2003-01-31 2006-07-06 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体
WO2004103276A2 (en) * 2003-05-14 2004-12-02 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004110436A1 (en) * 2003-06-06 2004-12-23 Merck & Co., Inc. Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US7456204B2 (en) * 2003-06-17 2008-11-25 Merck & Co., Inc. Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CN1882551A (zh) * 2003-07-31 2006-12-20 麦克公司 用作用于治疗或预防糖尿病的二肽基肽酶－iv酶抑制剂的六氢二氮杂吖庚因酮
DE602004025132D1 (de) * 2003-09-18 2010-03-04 Takasago Perfumery Co Ltd Asymmetrische reduktive aminierung von ketosäurederivaten zur herstellung von aminosäurederivaten
CA2541212A1 (en) * 2003-11-04 2005-05-19 Wallace T. Ashton Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
KR20110136901A (ko) 2004-02-24 2011-12-21 상꾜 가부시키가이샤 아미노 알코올 화합물
WO2005108382A1 (en) * 2004-05-04 2005-11-17 Merck & Co., Inc. 1,2,4-oxadiazole derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
US7504413B2 (en) 2004-05-06 2009-03-17 Cytokinetics, Inc. N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
US7795448B2 (en) * 2004-05-06 2010-09-14 Cytokinetics, Incorporated Imidazoyl-benzamide anti-cancer agents
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
EP1604662A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
US20070197640A1 (en) * 2005-11-02 2007-08-23 Cytokinetics, Inc. Certain chemical entities, compositions, and methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2168929A (en) * 1936-12-12 1939-08-08 Winthrop Chem Co Inc Isoquinoline compounds and derivatives thereof
US3663608A (en) * 1969-12-10 1972-05-16 Bristol Myers Co 1-phenyl-3-aminoalkyl-1,2,3,4-tetrahydronaphthalenes and the salts thereof
US3704328A (en) * 1970-01-21 1972-11-28 James S Kaltenbronn 4- and 5-aryl-1-naphthaleneethanol compounds
US3663627A (en) * 1970-06-01 1972-05-16 Bristol Myers Co 1-indanmethanols
GB1400425A (en) * 1971-09-22 1975-07-16 Rolland Sa A Substituted 3-hydroxymethyl-isoquinolines and derivatives
US4022791A (en) * 1975-06-03 1977-05-10 Pfizer Inc. 2-Aminomethyl-3,4-dihydronaphthalenes

Also Published As

Publication number Publication date
ES8400093A1 (es) 1983-11-01
IT1168074B (it) 1987-05-20
GB8409163D0 (en) 1984-05-16
ES518692A0 (es) 1983-11-01
US4504663A (en) 1985-03-12
GR78081B (es) 1984-09-26
LU83850A1 (fr) 1983-09-02
ES508670A0 (es) 1983-06-01
GB2091250A (en) 1982-07-28
GB2137992B (en) 1985-05-09
US4431851A (en) 1984-02-14
SE8107537L (sv) 1982-06-23
DE3150876A1 (de) 1982-07-29
US4386090A (en) 1983-05-31
NL8105791A (nl) 1982-07-16
GB2137992A (en) 1984-10-17
AU7875781A (en) 1982-07-01
GB2091250B (en) 1984-11-14
CA1181748A (en) 1985-01-29
ES8400388A1 (es) 1983-11-01
IT8125722A0 (it) 1981-12-21
ES518693A0 (es) 1983-11-01

Similar Documents

Publication Publication Date Title
ES8400093A1 (es) Metodo de preparacion de derivados farmaceuticamente activosaminoalcoil heterociclicos.
EP0163599A3 (en) Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
MY109737A (en) Treatment and compounds.
GR3018182T3 (en) Derivatives of amidinophenylalanine, procedure for their preparation, their utilisation and anticoagulant compositions comprising them.
IL106387A (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
MX9204029A (es) Procedimiento de preparacion de un derivado de la bacatina iii y de la 10-desacetil bacatina iii
ES2091359T3 (es) Nuevo compuesto peptidico y un procedimiento para su preparacion.
IL98262A (en) Chromone derivatives and pharmaceutical compositions containing them
IE851205L (en) Beta-carbolines
NZ216785A (en) 3-phenyl-3-(3-aminopropyl)-dihydrobenzofuran derivatives and pharmaceutical compositions
ES551990A0 (es) Procedimiento para preparar un derivados de cefalosporina.
FI892344A0 (fi) 6-fenyl-3-piperazinylalkyl-1h,3h -pyrimidin-2-4-dionderivat, deras framstaellning och deras terapeutiska anvaendning.
IL96643A0 (en) Morpholinyl derivatives of doxorubicin,their preparation and pharmaceutical compositions containing them
ZA919752B (en) Fluorine compounds
ES2008962A6 (es) Proceso para la preparacion de nuevos compuestos de 2-guanidinotiazol
SE8303913D0 (sv) Heterocykliska foreningar
NZ212614A (en) Acetylenic phenoxypropanol derivatives and pharmaceutical compositions
EP0579836A4 (es)
NZ221004A (en) 2,6-piperazinediones and pharamceutical compositions
EP0418990A3 (en) 13-bromo and 13,14-dibromo ergoline, their preparation and their use
ZA881384B (en) Acetamides derived from 2,3-dihydro-3-phenyl-2-benzofuranone,processes for preparing them and the pharmaceutical compositions which contain them
EP0214566A3 (en) 3-propenyl pyridines and their use as fungicides
EP0230474A4 (en) BIS-DIOXOPIPERAZINE COMBATS AND MEDICINAL PRODUCTS THEREOF.
ES2001701A6 (es) Un metodo para preparar compuesto de benzoilurea
MY103577A (en) New aminoacylates of glycerol acetal