ES8307097A1 - Procedimiento para la obtencion de fosfatos flavanoidicos de aminoglicosido. - Google Patents

Procedimiento para la obtencion de fosfatos flavanoidicos de aminoglicosido.

Info

Publication number
ES8307097A1
ES8307097A1 ES512126A ES512126A ES8307097A1 ES 8307097 A1 ES8307097 A1 ES 8307097A1 ES 512126 A ES512126 A ES 512126A ES 512126 A ES512126 A ES 512126A ES 8307097 A1 ES8307097 A1 ES 8307097A1
Authority
ES
Spain
Prior art keywords
soluble salts
aminoglycoside antibiotics
hardly soluble
aminoglycoside
antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512126A
Other languages
English (en)
Other versions
ES512126A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES512126A0 publication Critical patent/ES512126A0/es
Publication of ES8307097A1 publication Critical patent/ES8307097A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER SALES POCO SOLUBLES DE ANTIBIOTICOS, PARTICULARMENTE FOSFATOS FLAVANOIDICOS DE AMINOGLICOSIDO. SE HACE REACCIONAR UNA SOLUCION ACUOSA DE LA SAL HIDROSOLUBLE DEL ANTIBIOTICO (POR EJEMPLO SULFATO DE GENTAMICINA) CON UNA SOLUCION ACUOSA DEL FOSFATO FLAVANOIDICO O DE UNA DE SUS SALES HIDROSOLUBLES (POR EJEMPLO DE LA SAL SODICA), CONVENIENTEMENTE BAJO AGITACION A TEMPERATURA AMBIENTE. PARA MEJORAR LA SOLUBILIDAD SE PUEDE AGREGAR UN DISOLVENTE ORGANICO, POR EJEMPLO UN ALCOHOL, TAL COMO ETANOL. LOS FOSFATOS FLAVANOIDICOS FORMADOS SE PUEDEN SEPARAR, AL SER POCO SOLUBLES EN AGUA, POR FILTRACION, LAVADO CON AGUA Y SECADO.
ES512126A 1981-05-13 1982-05-12 Procedimiento para la obtencion de fosfatos flavanoidicos de aminoglicosido. Expired ES8307097A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3118856 1981-05-13
DE19823206725 DE3206725A1 (de) 1981-05-13 1982-02-25 Schwer loesliche salze von aminoglykosidantibiotika

Publications (2)

Publication Number Publication Date
ES512126A0 ES512126A0 (es) 1983-07-01
ES8307097A1 true ES8307097A1 (es) 1983-07-01

Family

ID=25793203

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512126A Expired ES8307097A1 (es) 1981-05-13 1982-05-12 Procedimiento para la obtencion de fosfatos flavanoidicos de aminoglicosido.

Country Status (8)

Country Link
US (1) US4617293A (es)
EP (1) EP0065123B1 (es)
AU (1) AU554041B2 (es)
CA (1) CA1196628A (es)
DE (2) DE3206725A1 (es)
ES (1) ES8307097A1 (es)
HU (1) HU189138B (es)
IL (1) IL65749A (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3542972A1 (de) * 1985-12-05 1987-06-11 Merck Patent Gmbh Pharmakadepot
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
FR2623808B1 (fr) * 1987-12-01 1990-03-09 Adir Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US5128132A (en) * 1988-11-22 1992-07-07 Parnell Pharmaceuticals, Inc. Eriodictyon compositions and methods for treating internal mucous membranes
US5248501A (en) * 1988-11-22 1993-09-28 Parnell Pharmaceuticals Drug delivery systems containing eriodictyon fluid extract as an excipient, and methods and compositions associated therewith
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US5478579A (en) * 1991-02-06 1995-12-26 Biodyn Medical Research, Inc. Method for treatment of osteoporosis
DE4314871A1 (de) * 1993-05-05 1994-11-10 Merck Patent Gmbh Lösungsmittel für ein schwerlösliches Gentamicin-Salz
DE69804657T2 (de) * 1997-11-19 2002-11-28 Flavone Sunproducts A/S, Naestved Eine oder mehrere flavonide enthaltende zusammensetzung, verfahren zu ihrer herstellung und ihre verwendung als uv-absorbierendes mittel
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US20120046237A1 (en) * 1998-04-08 2012-02-23 Theoharides Theoharis C Compositions for protection against superficial vasodilator flush syndrome, and methods of use
US6576224B1 (en) * 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
ES2226886T3 (es) * 1999-08-31 2005-04-01 Grunenthal Gmbh Forma de administracion de accion retardada que contiene sacarinato de tramadol.
TWI282275B (en) * 2000-08-17 2007-06-11 Control Ox Oy Plant-derived and synthetic phenolic compounds and plant extracts, effective in the treatment and prevention of chlamydial infections
FI113942B (fi) * 2000-08-18 2004-07-15 Control Ox Oy Kasviperäisten fenolisten yhdisteiden käyttö valmistettaessa klamydiainfektion hoidossa ja ennaltaehkäisyssä käyttökelpoista farmaseuttista valmistetta, terveyteen myönteisesti vaikuttavaa ravintoainekoostumusta tai koostumusta lisättäväksi tällaisiin elintarvikkeisiin
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
DE10114364A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Verfahren zur Herstellung von antibiotischen Kompositen
DE10114245A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung
DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung
IS6389A (is) * 2001-08-31 2003-03-03 Heraeus Kulzer Gmbh & Co. Kg Reynsla af sýklalyfjahúðun skrokka, sem í eru örholrými, og einnig af þannig húðuðum skrokkum og notkun þeirra
IS6390A (is) 2001-08-31 2003-03-03 Heraeus Kulzer Gmbh & Co. Kg Reynsla af sýklalyfjahúðun skrokka sem í eru örholrými, þannig húðuðum skrokkum og einnig af notkunþeirra
DE10262176B4 (de) * 2002-06-21 2007-10-04 Heraeus Kulzer Gmbh Verfahren zur Herstellung von antibiotisch beschichteten porösen Körpern sowie Verwendung
DE10227938B4 (de) * 2002-06-21 2006-07-20 Heraeus Kulzer Gmbh Pharmazeutische Zubereitung, Verfahren zu ihrer Herstellung sowie deren Verwendung
US20060155234A1 (en) * 2002-09-10 2006-07-13 American National Red Cross Hemostatic dressing
DE10318991A1 (de) * 2003-04-25 2004-11-18 Heraeus Kulzer Gmbh & Co. Kg Poröser Körper mit antibiotischer Beschichtung, Verfahren zur Herstellung sowie Verwendung
US20060286084A1 (en) * 2003-09-30 2006-12-21 Yoshikazu Morita Agent for promoting osteogenesis and/or inhibiting bone resorption
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
EP1799228B1 (en) 2004-09-14 2010-04-14 Ajinomoto Omnichem S.A. Topical compositions containing phosphorylated polyphenols
CA2632968A1 (en) * 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
NZ574653A (en) 2006-08-04 2012-11-30 Stb Lifesaving Technologies Inc Solid dressing for treating wounded tissue
JP2010527913A (ja) * 2007-04-10 2010-08-19 アカオジェン インコーポレイテッド 抗菌性１，４，５置換アミノグリコシド類似体
WO2009020612A1 (en) 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
EA017824B1 (ru) 2007-11-21 2013-03-29 Эйкеоджен, Инк. Антибактериальные аналоги аминогликозида
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
MX2012004036A (es) 2009-10-09 2012-06-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos.
AR083879A1 (es) 2010-11-17 2013-03-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos
DE102015214603B4 (de) 2015-07-31 2019-01-24 Mathys Ag Bettlach Phosphorhaltige Aminoglycosid-Salze
WO2019059275A1 (ja) * 2017-09-21 2019-03-28 学校法人北陸大学 骨のリモデリング促進剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2962495A (en) * 1952-06-21 1960-11-29 Leo Ab Polymer phosphoric acid anti-enzymatic substances
US3091572A (en) * 1962-07-16 1963-05-28 Schering Corp Gentamycin and method of production

Also Published As

Publication number Publication date
DE3260448D1 (en) 1984-08-30
AU8358182A (en) 1982-11-18
ES512126A0 (es) 1983-07-01
HU189138B (en) 1986-06-30
EP0065123A1 (de) 1982-11-24
DE3206725A1 (de) 1982-12-02
US4617293A (en) 1986-10-14
AU554041B2 (en) 1986-08-07
IL65749A (en) 1985-05-31
IL65749A0 (en) 1982-08-31
EP0065123B1 (de) 1984-07-25
CA1196628A (en) 1985-11-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301