ES8308302A1 - Un procedimiento para la preparacion de-amino acidos n-sustituidos. - Google Patents
Un procedimiento para la preparacion de-amino acidos n-sustituidos.Info
- Publication number
- ES8308302A1 ES8308302A1 ES507916A ES507916A ES8308302A1 ES 8308302 A1 ES8308302 A1 ES 8308302A1 ES 507916 A ES507916 A ES 507916A ES 507916 A ES507916 A ES 507916A ES 8308302 A1 ES8308302 A1 ES 8308302A1
- Authority
- ES
- Spain
- Prior art keywords
- processes
- making
- amino acids
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001371 alpha-amino acids Chemical class 0.000 title 1
- 235000008206 alpha-amino acids Nutrition 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 methylenedioxy Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ~C-AMINOACIDOS N-SUBSTITUIDOS Y DE SUS SALES, ESTERES O BIOPRECURSORES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R<1 Y R<2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN AMINO COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R<2-X EN LAS QUE R<X ES HIDROGENO O GRUPO PROTECTOR DE CARBOXILO; X ES HALOGENO; R<1 Y R<2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); Y CUALQUIER GRUPO REACTIVO PUEDE ESTAR PROTEGIDO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA ALGO SUPERIOR A LA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ARTERIOESCLEROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7943794 | 1979-12-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES507916A0 ES507916A0 (es) | 1983-01-01 |
| ES8308302A1 true ES8308302A1 (es) | 1983-01-01 |
Family
ID=10509949
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497907A Granted ES497907A0 (es) | 1979-12-19 | 1980-12-18 | Un procedimiento para la preparacion de l-amino acidos n-sustituidos. |
| ES507915A Granted ES507915A0 (es) | 1979-12-19 | 1981-12-11 | Un procedimiento para la preparacion de-amino acidos n-sustttuidos. |
| ES507917A Expired ES8307205A1 (es) | 1979-12-19 | 1981-12-11 | Un procedimiento para la preparacion de-amino acidos n-sustituidos. |
| ES507916A Expired ES8308302A1 (es) | 1979-12-19 | 1981-12-11 | Un procedimiento para la preparacion de-amino acidos n-sustituidos. |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497907A Granted ES497907A0 (es) | 1979-12-19 | 1980-12-18 | Un procedimiento para la preparacion de l-amino acidos n-sustituidos. |
| ES507915A Granted ES507915A0 (es) | 1979-12-19 | 1981-12-11 | Un procedimiento para la preparacion de-amino acidos n-sustttuidos. |
| ES507917A Expired ES8307205A1 (es) | 1979-12-19 | 1981-12-11 | Un procedimiento para la preparacion de-amino acidos n-sustituidos. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0031653A1 (es) |
| JP (1) | JPS5692843A (es) |
| AU (1) | AU6546780A (es) |
| DK (1) | DK541580A (es) |
| ES (4) | ES497907A0 (es) |
| GR (1) | GR72257B (es) |
| IL (1) | IL61675A0 (es) |
| NO (1) | NO803835L (es) |
| ZA (1) | ZA807795B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0067641A3 (en) * | 1981-06-17 | 1983-03-09 | Beecham Group Plc | Amino acids |
| US5245046A (en) * | 1988-11-14 | 1993-09-14 | The Upjohn Company | α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
| JPH04501722A (ja) * | 1988-11-14 | 1992-03-26 | ジ・アップジョン・カンパニー | 抗―糖尿病、抗―肥満症および抗―アテローム性動脈硬化症薬として有用なα―アミノ―インドール―３―酢酸 |
| EP0375133A1 (en) * | 1988-11-14 | 1990-06-27 | The Upjohn Company | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
| US5163131A (en) * | 1989-09-08 | 1992-11-10 | Auspex Systems, Inc. | Parallel i/o network file server architecture |
| KR101317947B1 (ko) * | 2013-07-04 | 2013-10-16 | 이영우 | 실린더 검사장치 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950542A (en) * | 1967-02-21 | 1976-04-13 | L'oreal | Cysteamine derivatives for oral treatment of seborrhea |
-
1980
- 1980-12-05 EP EP80304407A patent/EP0031653A1/en not_active Ceased
- 1980-12-09 IL IL61675A patent/IL61675A0/xx unknown
- 1980-12-12 ZA ZA00807795A patent/ZA807795B/xx unknown
- 1980-12-17 NO NO803835A patent/NO803835L/no unknown
- 1980-12-17 AU AU65467/80A patent/AU6546780A/en not_active Abandoned
- 1980-12-18 ES ES497907A patent/ES497907A0/es active Granted
- 1980-12-18 DK DK541580A patent/DK541580A/da unknown
- 1980-12-18 GR GR63711A patent/GR72257B/el unknown
- 1980-12-19 JP JP18031880A patent/JPS5692843A/ja active Pending
-
1981
- 1981-12-11 ES ES507915A patent/ES507915A0/es active Granted
- 1981-12-11 ES ES507917A patent/ES8307205A1/es not_active Expired
- 1981-12-11 ES ES507916A patent/ES8308302A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES507916A0 (es) | 1983-01-01 |
| EP0031653A1 (en) | 1981-07-08 |
| ES507917A0 (es) | 1982-11-01 |
| ES8301460A1 (es) | 1982-05-01 |
| ES497907A0 (es) | 1982-05-01 |
| JPS5692843A (en) | 1981-07-27 |
| DK541580A (da) | 1981-06-20 |
| GR72257B (es) | 1983-10-06 |
| AU6546780A (en) | 1981-06-25 |
| ES8306096A1 (es) | 1982-10-01 |
| ES507915A0 (es) | 1982-10-01 |
| ES8307205A1 (es) | 1982-11-01 |
| NO803835L (no) | 1981-06-22 |
| IL61675A0 (en) | 1981-01-30 |
| ZA807795B (en) | 1982-01-27 |
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