ES8400121A1 - Procedimiento para la obtencion de derivados de 11-amino-papulacandina a y b. - Google Patents
Procedimiento para la obtencion de derivados de 11-amino-papulacandina a y b.Info
- Publication number
- ES8400121A1 ES8400121A1 ES516589A ES516589A ES8400121A1 ES 8400121 A1 ES8400121 A1 ES 8400121A1 ES 516589 A ES516589 A ES 516589A ES 516589 A ES516589 A ES 516589A ES 8400121 A1 ES8400121 A1 ES 8400121A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- papulacandin
- aminopapulacandin
- compounds
- antibiotic activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- DPVWBQZOSHCQTG-UHFFFAOYSA-N Papulacandin A Natural products OC1C(O)C(O)C(COC(=O)C=CC=CCCCCC)OC1OC1C(OC(=O)C=CC=CCC(O)C(C)=CC=CCCC(C)CC)C(O)C2(C3=C(O)C=C(O)C=C3CO2)OC1CO DPVWBQZOSHCQTG-UHFFFAOYSA-N 0.000 abstract 2
- UJLFRJFJTPPIOK-XALDCVGDSA-N Papulacandin B Natural products CCC(C)CCC=CC=C(/C)C(O)CC=CC=CC(=O)OC1C(O)C2(OCc3cc(O)cc(O)c23)OC(CO)C1OC4OC(COC(=O)C=CC=C/C=C/C(O)CC)C(O)C(O)C4O UJLFRJFJTPPIOK-XALDCVGDSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UJLFRJFJTPPIOK-RZGJRGQUSA-N papulacandin b Chemical compound O([C@@H]1[C@@H](CO)O[C@@]2(C3=C(O)C=C(O)C=C3CO2)[C@H](O)[C@H]1OC(=O)/C=C/C=C/C[C@H](O)C(/C)=C/C=C/CC[C@@H](C)CC)[C@@H]1O[C@H](COC(=O)\C=C\C=C/C=C/C(O)CC)[C@H](O)[C@H](O)[C@H]1O UJLFRJFJTPPIOK-RZGJRGQUSA-N 0.000 abstract 2
- 108010058641 papulacandins Proteins 0.000 abstract 2
- 241000222122 Candida albicans Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- XKSZJTQIZHUMGA-KDCKXVQZSA-N [(3'r,4's,5'r,6'r)-3',4,5',6-tetrahydroxy-6'-(hydroxymethyl)spiro[1h-2-benzofuran-3,2'-oxane]-4'-yl] (2e,4e,8e,10e)-7-hydroxy-8,14-dimethylhexadeca-2,4,8,10-tetraenoate Chemical class O[C@@H]1[C@@H](OC(=O)/C=C/C=C/CC(O)C(/C)=C/C=C/CCC(C)CC)[C@H](O)[C@@H](CO)OC11C2=C(O)C=C(O)C=C2CO1 XKSZJTQIZHUMGA-KDCKXVQZSA-N 0.000 abstract 1
- 230000001857 anti-mycotic effect Effects 0.000 abstract 1
- 239000002543 antimycotic Substances 0.000 abstract 1
- 229940095731 candida albicans Drugs 0.000 abstract 1
- 229910052739 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- DPVWBQZOSHCQTG-NVTMJBNDSA-N papulacandin A Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](COC(=O)/C=C/C=C/CCCCC)O[C@H]1O[C@H]1[C@H](OC(=O)\C=C\C=C\C[C@H](O)C(\C)=C\C=C\CC[C@@H](C)CC)[C@@H](O)[C@]2(C3=C(O)C=C(O)C=C3CO2)O[C@@H]1CO DPVWBQZOSHCQTG-NVTMJBNDSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 11-AMINOPAPULACANDINA A Y B.SE HACE REACCIONAR UN DERIVADO DE PAPULACANDINA (II) CON UN ANHIDRIDO DE ACIDO ARILSELENICO Y HEXA-ALQUILO INFERIOR-DIRILAZANO PARA A CONTINUACION TRATAR CON UN AGENTE REDUCTOR PARA OBTENER LA BASE O SAL CORRESPONDIENTE (I). PAP SIGNIFICA LA PARTE RESTANTE DE LA PAPULACANDINA A O B Y RO SIGNIFICA METILO O UN GRUPO PROTECTOR HIDROXILO.ACTIVIDAD ANTIBIOTICA CONTRA LOS HONGOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH926680 | 1980-12-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES516589A0 ES516589A0 (es) | 1983-10-16 |
| ES8400121A1 true ES8400121A1 (es) | 1983-10-16 |
Family
ID=4350126
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507984A Expired ES8303448A1 (es) | 1980-12-16 | 1981-12-15 | Procedimiento para la obtencion de derivados de n-acilados de 11-amino de la papulacandina a y b. |
| ES516589A Expired ES8400121A1 (es) | 1980-12-16 | 1982-10-16 | Procedimiento para la obtencion de derivados de 11-amino-papulacandina a y b. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507984A Expired ES8303448A1 (es) | 1980-12-16 | 1981-12-15 | Procedimiento para la obtencion de derivados de n-acilados de 11-amino de la papulacandina a y b. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4374129A (es) |
| EP (1) | EP0054514A1 (es) |
| JP (1) | JPS57123200A (es) |
| DK (1) | DK556581A (es) |
| ES (2) | ES8303448A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089478A (en) * | 1988-10-17 | 1992-02-18 | Merck & Co., Inc. | Method for the control of pneumocystis carinii |
| US5091413A (en) * | 1990-02-13 | 1992-02-25 | Merck & Co., Inc. | Antibiotic agent |
| KR100701429B1 (ko) * | 2005-09-02 | 2007-03-30 | 한국전자통신연구원 | 수신모듈 및 이를 포함한 수신기 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS553358B2 (es) * | 1973-03-13 | 1980-01-24 | ||
| US3960833A (en) * | 1974-11-29 | 1976-06-01 | Bristol-Myers Company | Butirosin A 3",5"-O-isopropylidene derivatives |
| DE2609611A1 (de) * | 1975-03-13 | 1976-09-23 | Ciba Geigy Ag | Verfahren zur herstellung eines neuen antibiotikums |
| US4136254A (en) * | 1976-06-17 | 1979-01-23 | Schering Corporation | Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby |
| LU75760A1 (es) * | 1976-09-09 | 1978-04-27 |
-
1981
- 1981-12-11 EP EP81810489A patent/EP0054514A1/de not_active Withdrawn
- 1981-12-14 US US06/330,409 patent/US4374129A/en not_active Expired - Fee Related
- 1981-12-15 DK DK556581A patent/DK556581A/da not_active Application Discontinuation
- 1981-12-15 ES ES507984A patent/ES8303448A1/es not_active Expired
- 1981-12-16 JP JP56201757A patent/JPS57123200A/ja active Pending
-
1982
- 1982-10-16 ES ES516589A patent/ES8400121A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0054514A1 (de) | 1982-06-23 |
| ES507984A0 (es) | 1983-02-01 |
| ES516589A0 (es) | 1983-10-16 |
| US4374129A (en) | 1983-02-15 |
| JPS57123200A (en) | 1982-07-31 |
| DK556581A (da) | 1982-06-17 |
| ES8303448A1 (es) | 1983-02-01 |
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