ES8401068A1 - Procedimiento para la preparacion de derivados de corinanteina, asi como de sus sales de adicion acida fisiologicamente inocuas. - Google Patents

Procedimiento para la preparacion de derivados de corinanteina, asi como de sus sales de adicion acida fisiologicamente inocuas.

Info

Publication number
ES8401068A1
ES8401068A1 ES519743A ES519743A ES8401068A1 ES 8401068 A1 ES8401068 A1 ES 8401068A1 ES 519743 A ES519743 A ES 519743A ES 519743 A ES519743 A ES 519743A ES 8401068 A1 ES8401068 A1 ES 8401068A1
Authority
ES
Spain
Prior art keywords
corynantheine
derivatives
preparation
present
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519743A
Other languages
English (en)
Other versions
ES519743A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Publication of ES8401068A1 publication Critical patent/ES8401068A1/es
Publication of ES519743A0 publication Critical patent/ES519743A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CORINANTEINA, DE FORMULA GENERAL (I), EN LA QUE R SIGNIFICA UN ATOMO DE HIDROGENO O ALCALINO, Y SUS SALES DE ADICION ACIDA FISIOLOGICAMENTE INOCUAS.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HIDROGENAN CATALITICAMENTE CORINANTEINA Y DIHIDROCORINANTEINA O MEZCLAS DE MATERIALES QUE CONTENGAN AMBAS SUSTANCIAS; SEGUNDA, LA TETRAHIDROCORINANTEINA OBTENIDA SE SAPONIFICA HASTA CONVERTIRLA EN ACIDO LIBRE; TERCERA, EL ACIDO LIBRE ES TRANSDUCIDO EN SUS ESTERES ALQUILOS O EN SUS SALES, MEDIANTE BASES INORGANICASY AMINAS FISIOLOGICAMENTE INOCUAS; Y POR ULTIMO, LAS SOLUCIONES DE REACCION OBTENIDAS SE HACEN REACCIONAR CON UN ACIDO INORGANICO FUERTE PARA LA FORMACION DE LAS SALES DE ACIDO CORRESPONDIENTES.DE APLICACION EN EL TRATAMIENTO DE PERTURBACIONES DEL RIEGO SANGUINEO.
ES519743A 1982-02-12 1983-02-11 Procedimiento para la preparacion de derivados de corinanteina, asi como de sus sales de adicion acida fisiologicamente inocuas. Granted ES519743A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823204960 DE3204960A1 (de) 1982-02-12 1982-02-12 Corynanthein-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES8401068A1 true ES8401068A1 (es) 1983-12-01
ES519743A0 ES519743A0 (es) 1983-12-01

Family

ID=6155512

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519743A Granted ES519743A0 (es) 1982-02-12 1983-02-11 Procedimiento para la preparacion de derivados de corinanteina, asi como de sus sales de adicion acida fisiologicamente inocuas.

Country Status (9)

Country Link
US (1) US4528289A (es)
EP (1) EP0086416A3 (es)
JP (1) JPS58159492A (es)
CA (1) CA1250582A (es)
DE (1) DE3204960A1 (es)
ES (1) ES519743A0 (es)
IE (1) IE830278L (es)
MX (1) MX7130E (es)
ZA (1) ZA83592B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
US4624954A (en) * 1985-12-20 1986-11-25 American Home Products Corporation 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments
US4665183A (en) * 1985-12-20 1987-05-12 American Home Products Corp. Process for preparing 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof useful for the treatment of cognitive impairments
KR100392292B1 (ko) * 2000-01-07 2003-07-22 주식회사 펩트론 5원환 융합 방향족 헤테로사이클릭 화합물을 유효성분으로 하는 hcv 치료제 조성물
US20020176876A1 (en) * 2001-01-23 2002-11-28 Harris Dennis H. Topical therapeutic skin care system
DE102005053241A1 (de) * 2005-11-08 2007-05-16 Schwabe Willmar Gmbh & Co Extrakte aus der Rinde von Corynanthe-Arten und deren Verwendung sowie diese Extrakte enthaltende Arzneimittel, diätetische Lebensmittel und pharmazeutische Zubereitungen
CN103804377A (zh) * 2012-11-08 2014-05-21 复旦大学 柯楠因碱类化合物及其制备方法
US9199960B2 (en) * 2013-05-02 2015-12-01 Frederick R. Ferri Method and apparatus for processing herbaceous plant materials including the cannabis plant
CN106008500A (zh) * 2013-11-07 2016-10-12 复旦大学 柯楠因碱类化合物及其制备方法
CN104945405A (zh) * 2014-03-27 2015-09-30 复旦大学 毛钩藤碱类似物及其合成方法与应用
CN104974154B (zh) * 2014-04-01 2017-04-12 复旦大学 毛钩藤碱类似物及其在制备抗高血压药物中的用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL113232C (es) *

Also Published As

Publication number Publication date
US4528289A (en) 1985-07-09
CA1250582A (en) 1989-02-28
IE830278L (en) 1983-08-12
EP0086416A2 (de) 1983-08-24
ZA83592B (en) 1983-11-30
MX7130E (es) 1987-07-08
EP0086416A3 (de) 1984-04-04
DE3204960A1 (de) 1983-08-25
JPS58159492A (ja) 1983-09-21
ES519743A0 (es) 1983-12-01

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