ES8401317A1 - Mejoras introducidas en la manufactura de un inserto ocular biosoluble. - Google Patents

Mejoras introducidas en la manufactura de un inserto ocular biosoluble.

Info

Publication number
ES8401317A1
ES8401317A1 ES516205A ES516205A ES8401317A1 ES 8401317 A1 ES8401317 A1 ES 8401317A1 ES 516205 A ES516205 A ES 516205A ES 516205 A ES516205 A ES 516205A ES 8401317 A1 ES8401317 A1 ES 8401317A1
Authority
ES
Spain
Prior art keywords
pharmacologically active
eye insert
biosoluble
manufacture
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516205A
Other languages
English (en)
Other versions
ES516205A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8401317A1 publication Critical patent/ES8401317A1/es
Publication of ES516205A0 publication Critical patent/ES516205A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Steroid Compounds (AREA)

Abstract

INSERTO OCULAR BIOSOLUBLE, CON O SIN AGENTES FARMACOLOGICAMENTE ACTIVOS, CONSTITUIDO POR POLIMEROS DE BAJO PESO MOLECULAR QUE NO PRODUCEN VISION BORROSA.SE PREPARA UNA COMPOSICION DE ALCOHOL POLIVINILICO, PLASTIFICANTE, HIDROXIPROPILCELULOSA, POLIVINILPIRROLIDONA, ALCOHOL MONOSACARIDO, POLIMERO DE LOS UTILIZADOS PARA RECUBRIMIENTOS ENTERICOS HOMOGENEAMENTE DISTRIBUIDO DENTRO DE LA MATRIZ DEL INJERTO Y UN AGENTE FARMACOLOGICAMENTE ACTIVO. SE CALIENTA ENTRE 65 Y 204JC PARA HOMOGENEIZAR LA MEZCLA, SE MOLDEA POR COMPRESION PARA FORMAR UNA PELICULA DELGADA DE 0,5 A1,5 MM DE ESPESOR O POR EXTRUSION PARA FORMAR VARILLAS CON UN DIAMETRO DE 0,5 A 1,5 MM Y SE CORTAN SECCIONES ADECUADAS PARA PROPORCIONAR LA DOSIS DESEADA DE MEDICAMENTO.
ES516205A 1981-10-08 1982-10-04 Mejoras introducidas en la manufactura de un inserto ocular biosoluble. Granted ES516205A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30985281A 1981-10-08 1981-10-08

Publications (2)

Publication Number Publication Date
ES8401317A1 true ES8401317A1 (es) 1983-12-16
ES516205A0 ES516205A0 (es) 1983-12-16

Family

ID=23199947

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516205A Granted ES516205A0 (es) 1981-10-08 1982-10-04 Mejoras introducidas en la manufactura de un inserto ocular biosoluble.

Country Status (9)

Country Link
EP (1) EP0077261B1 (es)
JP (1) JPS5875547A (es)
AT (1) ATE28562T1 (es)
CA (1) CA1219213A (es)
DE (1) DE3276848D1 (es)
DK (1) DK444482A (es)
ES (1) ES516205A0 (es)
GR (1) GR77712B (es)
PT (1) PT75625B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1223150B (it) * 1987-11-18 1990-09-12 Ubaldo Conte Compressa per uso oftalmico e rilascio controllato della sostanza attiva
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
FR2688694B1 (fr) * 1992-03-20 1999-06-25 Vetoquinol Sa Insert ophtalmique bioadhesif.
AU5092493A (en) * 1992-09-08 1994-03-29 Allergan, Inc. Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle
MY113268A (en) 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
US5773021A (en) * 1994-03-14 1998-06-30 Vetoquinol S.A. Bioadhesive ophthalmic insert
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6613355B2 (en) 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
US7845537B2 (en) 2006-01-31 2010-12-07 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
TWI826685B (zh) 2019-05-02 2023-12-21 瑞士商愛爾康公司 可溶解聚合物眼睛插入物及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE352811B (es) * 1971-06-04 1973-01-15 Pharmacia Ab
NL7111080A (es) * 1971-08-13 1973-02-13
SE375007B (es) * 1972-11-30 1975-04-07 Pharmacia Ab
US3968201A (en) * 1972-11-30 1976-07-06 Pharmacia Aktiebolag Dosage unit containing a substance showing a topical effect on the eye, and a method of preparing same
US4200098A (en) * 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent

Also Published As

Publication number Publication date
DK444482A (da) 1983-04-09
PT75625B (en) 1985-12-09
EP0077261A3 (en) 1984-03-28
EP0077261B1 (en) 1987-07-29
PT75625A (en) 1982-10-01
JPS5875547A (ja) 1983-05-07
DE3276848D1 (de) 1987-09-03
EP0077261A2 (en) 1983-04-20
CA1219213A (en) 1987-03-17
ES516205A0 (es) 1983-12-16
ATE28562T1 (de) 1987-08-15
GR77712B (es) 1984-09-25

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