ES8401461A1 - Procedimiento para la preparacion de derivados de 2-pirrolin-3-carbonitrilo. - Google Patents

Procedimiento para la preparacion de derivados de 2-pirrolin-3-carbonitrilo.

Info

Publication number
ES8401461A1
ES8401461A1 ES520876A ES520876A ES8401461A1 ES 8401461 A1 ES8401461 A1 ES 8401461A1 ES 520876 A ES520876 A ES 520876A ES 520876 A ES520876 A ES 520876A ES 8401461 A1 ES8401461 A1 ES 8401461A1
Authority
ES
Spain
Prior art keywords
straight
chained
compounds
alk
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520876A
Other languages
English (en)
Other versions
ES520876A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Publication of ES8401461A1 publication Critical patent/ES8401461A1/es
Publication of ES520876A0 publication Critical patent/ES520876A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Lock And Its Accessories (AREA)
  • Specific Sealing Or Ventilating Devices For Doors And Windows (AREA)
  • Inorganic Fibers (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE 2-PIRROLIN-3-CARBONITRILO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 SON ANILLOS AROMATICOS; ALK ES UN RADICAL HIDROCARBONADO; Y Z PUEDE SER VARIOS RADICALES.CONSISTE EN LA REACCION DE TRANSPOSICION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), POR TRATAMIENTO A REFLUJO EN UN DISOLVENTE INERTE POLAR, EN PRESENCIA DE UNA BASE FUERTE; SEGUIDA DE LA REACCION DEL PRODUCTO FORMADO CON UN COMPUESTO DE FORMULA X-ALK-Z, EN LAQUE X ES UN GRUPO ESTER O ETER REACTIVO, Y Z Y ALK SON LOS MISMOS QUE EN LA FORMULA (I).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y ULCERATIVAS.
ES520876A 1982-04-03 1983-03-23 Procedimiento para la preparacion de derivados de 2-pirrolin-3-carbonitrilo. Granted ES520876A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823212591 DE3212591A1 (de) 1982-04-03 1982-04-03 2-pyrrolin-3-carbonitril-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8401461A1 true ES8401461A1 (es) 1983-12-16
ES520876A0 ES520876A0 (es) 1983-12-16

Family

ID=6160255

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520876A Granted ES520876A0 (es) 1982-04-03 1983-03-23 Procedimiento para la preparacion de derivados de 2-pirrolin-3-carbonitrilo.

Country Status (15)

Country Link
US (2) US4517185A (es)
EP (1) EP0091045B1 (es)
JP (1) JPS58185560A (es)
AT (1) ATE18209T1 (es)
AU (1) AU1310283A (es)
CA (1) CA1191135A (es)
DD (1) DD209620A5 (es)
DE (2) DE3212591A1 (es)
DK (1) DK149083A (es)
ES (1) ES520876A0 (es)
FI (1) FI831051L (es)
HU (1) HU187883B (es)
SU (1) SU1195902A3 (es)
YU (1) YU67483A (es)
ZA (1) ZA831904B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3317653A1 (de) * 1983-05-14 1984-11-15 Gödecke AG, 1000 Berlin 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile, verfahren zu deren herstellung sowie deren verwendung bei der prophylaxe und therapie thrombotischer zustaende
DE3804221A1 (de) * 1987-09-18 1989-03-30 Ruetgerswerke Ag Haarfaerbemittel
US20110136711A1 (en) * 2009-12-03 2011-06-09 Chevron Oronite Company Llc Highly overbased magnesium alkytoluene sulfonates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL176372B (nl) * 1952-02-26 Salvat Editores Werkwijze voor het bereiden van drukinkt alsmede werkwijze voor het bereiden van een preparaat om aan drukinkt te worden toegevoegd.
GB1427945A (en) * 1973-08-22 1976-03-10 Lepetit Spa Aminopyrrole derivatives
NZ182263A (en) * 1975-10-25 1979-01-11 Beecham Group Ltd 2-carboxyalkyl-4,4-dimethyl-1-hydroxy-alkyl-pyrrolidin-3,5-dione derivativesand pharmaceutical compositions
US4329343A (en) * 1981-01-26 1982-05-11 Sanofi Pyrrole amides and therapeutic use thereof

Also Published As

Publication number Publication date
DE3212591A1 (de) 1983-10-13
DE3362243D1 (en) 1986-04-03
CA1191135A (en) 1985-07-30
SU1195902A3 (ru) 1985-11-30
FI831051A0 (fi) 1983-03-28
EP0091045B1 (de) 1986-02-26
FI831051A7 (fi) 1983-10-04
FI831051L (fi) 1983-10-04
ZA831904B (en) 1983-11-30
EP0091045A1 (de) 1983-10-12
ATE18209T1 (de) 1986-03-15
YU67483A (en) 1986-02-28
DK149083A (da) 1983-10-04
JPS58185560A (ja) 1983-10-29
US4517185A (en) 1985-05-14
DK149083D0 (da) 1983-03-30
HU187883B (en) 1986-02-28
US4598076A (en) 1986-07-01
DD209620A5 (de) 1984-05-16
ES520876A0 (es) 1983-12-16
AU1310283A (en) 1983-10-06

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