ES8401945A1 - Procedimiento para preparar derivados de dibenzo(de,g)quinoleina. - Google Patents

Procedimiento para preparar derivados de dibenzo(de,g)quinoleina.

Info

Publication number
ES8401945A1
ES8401945A1 ES521140A ES521140A ES8401945A1 ES 8401945 A1 ES8401945 A1 ES 8401945A1 ES 521140 A ES521140 A ES 521140A ES 521140 A ES521140 A ES 521140A ES 8401945 A1 ES8401945 A1 ES 8401945A1
Authority
ES
Spain
Prior art keywords
dibenzo
preparation
processes
quinolines
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521140A
Other languages
English (en)
Other versions
ES521140A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Publication of ES521140A0 publication Critical patent/ES521140A0/es
Publication of ES8401945A1 publication Critical patent/ES8401945A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE DIBENZO (DE, G) QUINOLEINA.CONSISTE EN LA OBTENCION DE COMPUESTOS DE FORMULA GENERAL (I) A PARTIR DE LOS METODOS SIGUIENTES: A) SOMETER A N-ALQUENILACION, N-ALQUINILACION O N-CICLOALCOHILACION COMPUESTOS DE FORMULA GENERAL (II) Y POSTERIOR CICLISACION, SEGUIDA DE O-METILACION; B) SOMETER A N-ALQUENILACION, N-ALQUINILACION O N-CICLOALCOHILALCOHILACION COMPUESTOS DE FORMULA (III), POSTERIOR CICLISACION Y SUBSIGUIENTE O-METILACION, DONDE R ES UN RADICAL HIDROCARBONADO ALIFATICO INSATURADO DE C 1 A 6, O UN RADICAL CICLOALCOHILALCOHILO DE C 4 A6, POR EJEMPLO, UN RADICAL ALILO, METALILO, DIMETILALILO, BUT-2-ENILO Y OTROS; R Y R SON ATOMOS DE HIDROGENO O RADICALES DE METILO. LA N-ALQUINILACION, N-ALQUENILACION O N-CICLOALCOHILALCOHILACION TIENE LUGAR MEDIANTE DERIVADOS REACTIVOS DE FORMULA GENERAL X-R, DONDE X ES UN ATOMO DE HALOGENO.TIENE APLICACIONES FARMACOLOGICAS POR SU ACCION ANALGESICA Y ANTIALERGICA.
ES521140A 1981-05-09 1983-03-30 Procedimiento para preparar derivados de dibenzo(de,g)quinoleina. Expired ES8401945A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813118521 DE3118521A1 (de) 1981-05-09 1981-05-09 Dibenzo(de,g)chinolin-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkaeltungskrankheiten und allergien

Publications (2)

Publication Number Publication Date
ES521140A0 ES521140A0 (es) 1984-01-01
ES8401945A1 true ES8401945A1 (es) 1984-01-01

Family

ID=6131937

Family Applications (3)

Application Number Title Priority Date Filing Date
ES511983A Expired ES8401470A1 (es) 1981-05-09 1982-05-07 "procedimiento para preparar derivados de dibenzo quinoleina".
ES521140A Expired ES8401945A1 (es) 1981-05-09 1983-03-30 Procedimiento para preparar derivados de dibenzo(de,g)quinoleina.
ES524475A Expired ES8406443A1 (es) 1981-05-09 1983-07-27 Procedimiento para preparar derivados de dibenzo(de,g)quinoleina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES511983A Expired ES8401470A1 (es) 1981-05-09 1982-05-07 "procedimiento para preparar derivados de dibenzo quinoleina".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES524475A Expired ES8406443A1 (es) 1981-05-09 1983-07-27 Procedimiento para preparar derivados de dibenzo(de,g)quinoleina

Country Status (5)

Country Link
US (1) US4461895A (es)
EP (1) EP0064685A1 (es)
JP (1) JPS57192369A (es)
DE (1) DE3118521A1 (es)
ES (3) ES8401470A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210680B1 (en) 1999-06-11 2001-04-03 Univera Pharmaceuticals, Inc. Method for the prevention and treatment of chronic venous insufficiency
TWI225397B (en) * 2000-05-04 2004-12-21 Nat Science Council Uses of thaliporphine or its derivatives in treatment of cardiac diseases and preparation of the same
HUP0301971A3 (en) * 2000-08-23 2007-09-28 Lotus Pharmaceutical Co Uses of thaliporphine or its derivatives for producing pharmaceutical compositions suitable for treating cardiac diseases and the compounds
CN1323812C (zh) 2001-08-24 2007-07-04 沃丁顿北美公司 金属化的刀叉餐具
US20060191145A1 (en) * 2001-08-24 2006-08-31 Waddington North America, Inc. Metallized cutlery and tableware and method therefor
CA2531406A1 (en) * 2003-06-19 2004-12-23 Lotus Pharmaceutical Co., Ltd. Aporphine and oxoaporphine and the medical use thereof
DE10345572A1 (de) * 2003-09-29 2005-05-19 Covion Organic Semiconductors Gmbh Metallkomplexe
KR101079927B1 (ko) 2010-11-24 2011-11-04 동아제약주식회사 퀴놀린 유도체 화합물, 이의 제조방법 및 이를 포함하는 약학 조성물
CN106632041B (zh) * 2016-10-11 2019-07-12 安徽省逸欣铭医药科技有限公司 一种酒石酸左洛啡烷的制备方法
CN111196801B (zh) * 2020-01-14 2022-10-14 中国药科大学 阿朴菲类生物碱衍生物及其制备方法与用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
DE2757335C3 (de) * 1977-12-22 1982-03-25 Gödecke AG, 1000 Berlin Verfahren zur O-Methylierung von Hydroxyaporphinen
DE3013346A1 (de) * 1980-04-05 1981-10-15 Gödecke AG, 1000 Berlin Dibenz(de,g)isochinolin-derivate, verfahren zu deren herstellung, diese enthaltende arzneimittel sowie deren verwendung bei der bekaempfung von erkrankungen des zentralen nervensystems
DE3171561D1 (en) * 1980-05-08 1985-09-05 Univ Northeastern N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same

Also Published As

Publication number Publication date
DE3118521A1 (de) 1982-12-02
ES521140A0 (es) 1984-01-01
ES511983A0 (es) 1983-12-01
US4461895A (en) 1984-07-24
ES524475A0 (es) 1984-07-16
JPS57192369A (en) 1982-11-26
EP0064685A1 (de) 1982-11-17
ES8401470A1 (es) 1983-12-01
ES8406443A1 (es) 1984-07-16

Similar Documents

Publication Publication Date Title
AU553419B2 (en) New deiphosphonic acid derivatives
TW239126B (es)
HUT35642A (en) Process for preparing mevalonolactone analogues and derivatives thereof further pharmaceutical compositions containing such compounds
AU529663B2 (en) Piperidine alkyl ethers of coumarin and quinoline
ES8401961A1 (es) Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas.
ES8401470A1 (es) "procedimiento para preparar derivados de dibenzo quinoleina".
ES2001341A6 (es) Un procedimiento de producir un derivado de acido guanidinometilbenzoico.
AU557898B2 (en) Aminoethoxybenzylalcohol derivatives
DE3363550D1 (en) New nitro aliphatic compounds, process for preparation thereof and use thereof
ES8404360A1 (es) Un procedimiento para preparar compuestos de cefem.
AU558261B2 (en) Dialkylaminoalkyoxybenzylalcohol derivatives
EP0189272A3 (en) New furanone derivatives, processes for preparation thereof and use thereof
DE3261515D1 (en) Benzopyranyl ethers, process for their preparation and medicine containing those compounds and intermediates
SE8603589L (sv) Metylendioxifenantren- och stilbenderivat
IL60176A (en) (aminopiperidinopropyl)dimethyl xanthine derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
NZ218918A (en) 4-oxo-1,4-dihydro-quinoline 3-carboxamides,their preparation and pharmaceutical compositions containing them
ES8402284A1 (es) Un procedimiento para la preparacion de indoles.
GB2021588A (en) Bibenzyl Derivatives, the Preparation thereof and Pharmaceutical Compositions Containing them
ES8103079A1 (es) Un procedimiento para preparar derivados de fenotiazina
GR78773B (es)
AU7998087A (en) 1-hydroxyalkylxanthines, processes for their preparation and medicaments containing them
ES8307790A1 (es) Un procedimiento para preparacion de 3-(2-(4-piperidil)-1-alquiletil) indoles.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001