ES8401968A1 - Procedimiento para la obtencion de la cis-1-acetil-4-(4-((2-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-il)metoxi)fenil)piperazina. - Google Patents

Procedimiento para la obtencion de la cis-1-acetil-4-(4-((2-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-il)metoxi)fenil)piperazina.

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Publication number
ES8401968A1
ES8401968A1 ES518150A ES518150A ES8401968A1 ES 8401968 A1 ES8401968 A1 ES 8401968A1 ES 518150 A ES518150 A ES 518150A ES 518150 A ES518150 A ES 518150A ES 8401968 A1 ES8401968 A1 ES 8401968A1
Authority
ES
Spain
Prior art keywords
fungi
infections
treatment
compsn
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518150A
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English (en)
Other versions
ES518150A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inke SA
Original Assignee
Inke SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inke SA filed Critical Inke SA
Priority to ES518150A priority Critical patent/ES518150A0/es
Publication of ES8401968A1 publication Critical patent/ES8401968A1/es
Publication of ES518150A0 publication Critical patent/ES518150A0/es
Granted legal-status Critical Current

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Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LA CIS-1-ACETIL-4--42-(2,4-DICLOROFENIL)-2-(1H-IMIDAZOL-1-IL METIL)-1,3-DIOXOLANO-4-ILMETOXIFENILPIPERAZINA.CONSISTE EN QUE REACCIONAN EL IMIDAZOL DE FORMULA (II) CON LA CIS-1-ACETIL-4-4-2,4-(DICLOROFENIL)-2-BROMOET IL-1,3 DIOXOLANO-4-ILMETOXIFENIPIPERAZINA DE FORMULA (III), EN PRESENCIA DE LA DIMETILFORMAMIDA, A TEMPERATURAS ENTRE 140 Y 170JC Y CON UN GRAN EXCESO DE IMIDEZOL (3 A 30 VECES MAYOR QUE LA RELACION MOLAR ESTEQUIOMETRICA. OBTENER LA CIS-1-ACETIL-4-4-2-(2,4-DICLO ROFENIL)-2-(1H-IMIDAZOL-1-ILMETIL)-1,3-DIOXOLANO-4-ILMETO XIFENILPIPERIZINA DE FORMULA (I). EL PRODUCTO DE FORMULA (I), SE PUEDE RECRISTALIZAREN PRESENCIA DE UN DISOLVENTE COMO METILACETONA.TIENE PROPIEDADES FARMACOLOGICAS PARA EL TRATAMIENTO DE LAS INFECCIONES Y HONGOS.
ES518150A 1982-12-14 1982-12-14 Procedimiento para la obtencion de la cis-1-acetil-4-(4-((2-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-il)metoxi)fenil)piperazina. Granted ES518150A0 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES518150A ES518150A0 (es) 1982-12-14 1982-12-14 Procedimiento para la obtencion de la cis-1-acetil-4-(4-((2-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-il)metoxi)fenil)piperazina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES518150A ES518150A0 (es) 1982-12-14 1982-12-14 Procedimiento para la obtencion de la cis-1-acetil-4-(4-((2-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-il)metoxi)fenil)piperazina.

Publications (2)

Publication Number Publication Date
ES8401968A1 true ES8401968A1 (es) 1984-01-01
ES518150A0 ES518150A0 (es) 1984-01-01

Family

ID=8485059

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518150A Granted ES518150A0 (es) 1982-12-14 1982-12-14 Procedimiento para la obtencion de la cis-1-acetil-4-(4-((2-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-il)metoxi)fenil)piperazina.

Country Status (1)

Country Link
ES (1) ES518150A0 (es)

Also Published As

Publication number Publication date
ES518150A0 (es) 1984-01-01

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