ES8403109A1 - Un procedimiento para la preparacion de 4-(3-trifluormetilfenil)-1,2,3,6-tetrahidropiridinas. - Google Patents

Un procedimiento para la preparacion de 4-(3-trifluormetilfenil)-1,2,3,6-tetrahidropiridinas.

Info

Publication number
ES8403109A1
ES8403109A1 ES518545A ES518545A ES8403109A1 ES 8403109 A1 ES8403109 A1 ES 8403109A1 ES 518545 A ES518545 A ES 518545A ES 518545 A ES518545 A ES 518545A ES 8403109 A1 ES8403109 A1 ES 8403109A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
compositions containing
trifluoromethylphenyltetrahydropyridines
substituted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518545A
Other languages
English (en)
Other versions
ES518545A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8403109A1 publication Critical patent/ES8403109A1/es
Publication of ES518545A0 publication Critical patent/ES518545A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 4-(3-TRIFLUORMETILFENIL)-1,2,3,6-TETRAHIDROPIRIDINAS, DE FORMULA GENERAL (I), EN LA QUE R1 REPRESENTA UN GRUPI CICLOALQUILO QUE TIENE DE 3 A 7 ATOMOS DE CARBONO; Y N REPRESENTA 1, 2, 3 O 4, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN REDUCIR UN COMPUESTO, DE FORMULA GENERAL (II), EN LA QUE R1 Y N TIENEN LOS SIGNIFICADOS YA INDICADOS, MEDIANTE UN HIDRURO DE ALUMINIO O POR UN HIDRURO COMPLEJO DE LITIO Y DE LITIO, EN UN DISOLVENTE ORGANICO INERTE, Y A UNA TEMPERATURA COMPRENDIDA ENTRE 0 GRADOS Y LA TEMPERATURA DE EBULLICION DEL DISOLVENTEUTILIZADO.DE APLICACION EN FARMACIA POR SU ACTIVIDAD ANOREXICA.
ES518545A 1981-03-11 1982-12-23 Un procedimiento para la preparacion de 4-(3-trifluormetilfenil)-1,2,3,6-tetrahidropiridinas. Granted ES518545A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8104890A FR2501682A1 (fr) 1981-03-11 1981-03-11 Trifluoromethylphenylpyridines a activite anorexigene, un procede de preparation et compositions pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
ES8403109A1 true ES8403109A1 (es) 1984-03-01
ES518545A0 ES518545A0 (es) 1984-03-01

Family

ID=9256120

Family Applications (3)

Application Number Title Priority Date Filing Date
ES510302A Granted ES510302A0 (es) 1981-03-11 1982-03-10 Procedimiento para la preparacion de 4-(3-trifluormetilfenil)-1,2,3,6-tetrahidropiridinas.
ES518545A Granted ES518545A0 (es) 1981-03-11 1982-12-23 Un procedimiento para la preparacion de 4-(3-trifluormetilfenil)-1,2,3,6-tetrahidropiridinas.
ES527456A Granted ES527456A0 (es) 1981-03-11 1983-11-22 Un procedimiento para la preparacion de 4-(3-trifluormetilfenil-1,2,3,6-tetrahidropiridinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES510302A Granted ES510302A0 (es) 1981-03-11 1982-03-10 Procedimiento para la preparacion de 4-(3-trifluormetilfenil)-1,2,3,6-tetrahidropiridinas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES527456A Granted ES527456A0 (es) 1981-03-11 1983-11-22 Un procedimiento para la preparacion de 4-(3-trifluormetilfenil-1,2,3,6-tetrahidropiridinas

Country Status (20)

Country Link
US (2) US4472408A (es)
EP (1) EP0060176B1 (es)
JP (1) JPS57159766A (es)
AR (2) AR229174A1 (es)
AT (1) ATE11044T1 (es)
AU (1) AU547692B2 (es)
CA (1) CA1196643A (es)
DE (1) DE3261731D1 (es)
DK (1) DK152843C (es)
ES (3) ES510302A0 (es)
FI (1) FI76786C (es)
FR (1) FR2501682A1 (es)
GR (1) GR79178B (es)
IE (1) IE52365B1 (es)
IL (1) IL65169A0 (es)
NO (1) NO158736C (es)
NZ (1) NZ199973A (es)
PT (1) PT74559B (es)
YU (2) YU50782A (es)
ZA (1) ZA821518B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531707A1 (fr) * 1982-08-16 1984-02-17 Midy Spa Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
DE3438394A1 (de) * 1984-10-19 1986-04-30 Merck Patent Gmbh, 6100 Darmstadt Pyridinderivate
HU198454B (en) * 1987-12-14 1989-10-30 Richter Gedeon Vegyeszet Process for production of new derivatives of tetrahydrospiridin and medical compositions containing these compounds
FR2639226B1 (fr) * 1988-11-18 1993-11-05 Sanofi Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2672213B1 (fr) * 1991-02-05 1995-03-10 Sanofi Sa Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3125488A (en) * 1964-03-17 Method of inducing analgesia by
US3072648A (en) * 1963-01-08 X-phenyl-s
GB881894A (en) * 1958-04-22 1961-11-08 Paul Adriaan Jan Janssen Tetrahydropyridine derivatives
GB948071A (en) * 1959-05-01 1964-01-29 May & Baker Ltd New heterocyclic compounds
GB984364A (en) * 1961-07-28 1965-02-24 May & Baker Ltd Substituted piperidines and tetrahydropyridines
FR86403E (fr) * 1959-05-01 1966-02-04 May & Baker Ltd Nouveaux dérivés de la phényl-4 pipéridine et leur préparation
US3284457A (en) * 1964-01-17 1966-11-08 Degussa 1-lower alkyl-4-substituted phenyl-1, 2, 3, 6-tetrahydropyridines and acid addition salts
US3626066A (en) * 1967-12-13 1971-12-07 Robins Co Inc A H Arylpyridinyl-alkyl alcohol derivatives in compositions and methods for tranquilizing mammals
AT287711B (de) * 1968-06-25 1971-02-10 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen 1-Alkyl-1,2,5,6-tetrahydro-3-pyridylmethyl-carbonsäureestern sowie deren Säureadditionssalzen und quaternären Ammoniumverbindungen
DE2101997A1 (en) * 1971-01-16 1972-08-03 Farbenfabriken Bayer AG, 509öfLeverkusen 1-benzyl-4-subst-tetrahydropyridines - useful as intermediates for pharmaceuticals
US4024151A (en) * 1975-09-29 1977-05-17 E. R. Squibb & Sons, Inc. 4-Phenylpiperidinyl (and 4-phenyl-tetrahydropyridinyl) alkylamino-oxoalkanoic acids
US4012374A (en) * 1975-09-29 1977-03-15 E. R. Squibb & Sons, Inc. 1-[[4-Phenyl-piperidinyl (or tetrahydropyridinyl)]alkyl]-2,6-piperidinedione and analogs
FR2416886A1 (fr) * 1978-02-08 1979-09-07 Roussel Uclaf Nouveaux derives de la 3-phenyl-tetrahydropyridine et leurs sels, procedes de preparation et application a titre de medicaments

Also Published As

Publication number Publication date
DK105082A (da) 1982-09-12
JPH0435459B2 (es) 1992-06-11
IE52365B1 (en) 1987-09-30
IL65169A0 (en) 1982-05-31
FI76786C (fi) 1988-12-12
ES8407023A1 (es) 1984-09-01
FI820826L (fi) 1982-09-12
DK152843B (da) 1988-05-24
FR2501682B1 (es) 1984-03-16
IE820455L (en) 1982-09-11
ES8305329A1 (es) 1983-04-01
NZ199973A (en) 1984-10-19
EP0060176A1 (fr) 1982-09-15
AR229174A1 (es) 1983-06-30
AR228330A1 (es) 1983-02-15
JPS57159766A (en) 1982-10-01
ZA821518B (en) 1983-01-26
ES510302A0 (es) 1983-04-01
GR79178B (es) 1984-10-02
NO158736C (no) 1988-10-26
ES527456A0 (es) 1984-09-01
DK152843C (da) 1988-10-03
FI76786B (fi) 1988-08-31
ES518545A0 (es) 1984-03-01
YU195484A (en) 1985-03-20
PT74559B (fr) 1983-11-10
ATE11044T1 (de) 1985-01-15
PT74559A (fr) 1982-04-01
EP0060176B1 (fr) 1985-01-02
AU547692B2 (en) 1985-10-31
US4602024A (en) 1986-07-22
NO158736B (no) 1988-07-18
DE3261731D1 (en) 1985-02-14
AU8111182A (en) 1982-09-16
CA1196643A (en) 1985-11-12
NO820767L (no) 1982-09-13
US4472408A (en) 1984-09-18
FR2501682A1 (fr) 1982-09-17
YU50782A (en) 1985-03-20

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