ES8403129A1 - Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas. - Google Patents
Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas.Info
- Publication number
- ES8403129A1 ES8403129A1 ES519529A ES519529A ES8403129A1 ES 8403129 A1 ES8403129 A1 ES 8403129A1 ES 519529 A ES519529 A ES 519529A ES 519529 A ES519529 A ES 519529A ES 8403129 A1 ES8403129 A1 ES 8403129A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- tienobenzodiazepinones
- procedure
- preparation
- new substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 (1-methyl-4-piperidinyl)methyl Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000000026 anti-ulcerogenic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE TIENOBENZODIAZEPINONAS SUSTITUIDAS, DE FORMULA GENERAL (I), EN LA QUE R1 SIGNIFICA UN ATOMO DE HIDROGENO O UN GRUPO ALCOHILO CON 1 HASTA 4 ATOMOS DE CARBONO; R2 SIGNIFICA UN ATOMO DE HIDROGENO O DE HALOGENO O UN GRUPO ALCOHILO; Y R SIGNIFICA UN GRUPO (1-METIL-4-PIPERIDINIL)METILO O (1-METIL-1,2,5,6-TETRAHID RO-4-PIRIDINIL)METILO, Y SUS SALES POR ADICION CON ACIDOS INORGANICOS U ORGANICOS.CONSISTE EN ACILAR TIENOBENZODIAZEPINONAS, DE FORMULA GENERAL (II), EN LA QUE R1 Y R2 TIENEN LOS SIGNIFICADOS YA MENCIONADOS, CON DERIVADOS DE ACIDOS DE FORMULA GENERAL(III), EN LA QUE R TIENE EL SIGNIFICADO YA MENCIONADO; Y Z SIGNIFICA UN GRUPO NUCLEOFUGO, EN UN DISOLVENTE INERTE.DE APLICACION COMO INHIBIDORES DE ULCERAS Y DE SECRECIONES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823204153 DE3204153A1 (de) | 1982-02-06 | 1982-02-06 | Substituierte thienobenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES519529A0 ES519529A0 (es) | 1984-03-01 |
| ES8403129A1 true ES8403129A1 (es) | 1984-03-01 |
Family
ID=6155010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519529A Expired ES8403129A1 (es) | 1982-02-06 | 1983-02-04 | Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas. |
| ES526538A Granted ES526538A0 (es) | 1982-02-06 | 1983-10-18 | Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526538A Granted ES526538A0 (es) | 1982-02-06 | 1983-10-18 | Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4424225A (es) |
| EP (1) | EP0086982A1 (es) |
| JP (1) | JPS58146584A (es) |
| AU (1) | AU1112183A (es) |
| DE (1) | DE3204153A1 (es) |
| ES (2) | ES8403129A1 (es) |
| ZA (1) | ZA83772B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3409237A1 (de) * | 1984-03-14 | 1985-09-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| CH667657A5 (de) * | 1985-01-07 | 1988-10-31 | Sandoz Ag | Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine. |
| DE3529372A1 (de) * | 1985-08-16 | 1987-02-19 | Dompe Farmaceutici Spa | Aminoacyl-derivat von 4,9-dihydro-10h-pyrido(3,2-b)-thieno(3,2-e) (1,4)-diazepinon und von 4,9-dihydro-10h-pyrido(3,2-b)thieno(3,4-e) (1,4)diazepinon, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen |
| DE3726908A1 (de) * | 1987-08-13 | 1989-02-23 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3930262A1 (de) * | 1989-09-11 | 1991-03-21 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3930266A1 (de) * | 1989-09-11 | 1991-03-14 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US5324832A (en) * | 1991-07-03 | 1994-06-28 | The United States Of America As Represented By The Department Of Health And Human Services | Muscarinic antagonists |
| JP6510539B2 (ja) | 2014-01-09 | 2019-05-08 | ザ ジェイ． デヴィッド グラッドストーン インスティテューツ， ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デヴィッド グラッドストーン | 置換ベンゾオキサジン及び関連化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1795176C3 (de) * | 1968-08-20 | 1974-10-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | hT-substituierte 5-Aminoacetyl-5,10-dihydro-l lH-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11one und Verfahren zu ihrer Herstellung |
| US4381301A (en) | 1980-05-07 | 1983-04-26 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted tricyclic thieno compounds, their synthesis, their use, their compositions and their medicaments |
| IL62792A (en) * | 1980-05-07 | 1985-02-28 | Byk Gulden Lomberg Chem Fab | Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them |
-
1982
- 1982-02-06 DE DE19823204153 patent/DE3204153A1/de not_active Withdrawn
-
1983
- 1983-01-26 EP EP83100680A patent/EP0086982A1/de not_active Withdrawn
- 1983-01-31 US US06/462,379 patent/US4424225A/en not_active Expired - Fee Related
- 1983-02-03 JP JP58016868A patent/JPS58146584A/ja active Pending
- 1983-02-04 ZA ZA83772A patent/ZA83772B/xx unknown
- 1983-02-04 AU AU11121/83A patent/AU1112183A/en not_active Abandoned
- 1983-02-04 ES ES519529A patent/ES8403129A1/es not_active Expired
- 1983-10-18 ES ES526538A patent/ES526538A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES8407052A1 (es) | 1984-08-16 |
| DE3204153A1 (de) | 1983-08-11 |
| ES519529A0 (es) | 1984-03-01 |
| EP0086982A1 (de) | 1983-08-31 |
| JPS58146584A (ja) | 1983-09-01 |
| US4424225A (en) | 1984-01-03 |
| AU1112183A (en) | 1983-08-11 |
| ZA83772B (en) | 1984-10-31 |
| ES526538A0 (es) | 1984-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20010402 |