ES8403131A1 - Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico. - Google Patents

Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico.

Info

Publication number
ES8403131A1
ES8403131A1 ES518969A ES518969A ES8403131A1 ES 8403131 A1 ES8403131 A1 ES 8403131A1 ES 518969 A ES518969 A ES 518969A ES 518969 A ES518969 A ES 518969A ES 8403131 A1 ES8403131 A1 ES 8403131A1
Authority
ES
Spain
Prior art keywords
dioxide derivatives
intermediates useful
penicillanic acid
certain intermediates
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518969A
Other languages
English (en)
Other versions
ES518969A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8403131A1 publication Critical patent/ES8403131A1/es
Publication of ES518969A0 publication Critical patent/ES518969A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 1,1-DIOXIDO DEL ACIDO PENICILANICO, DE FORMULA GENERAL (I), EN LA QUE X ES CL, BR O I; Y Y Z SON CADA UNO DE ELLOS CL, BR O I.CONSISTE EN OXIDAR UN COMPUESTO DE FORMULA (II), EN LA QUE X, Y Y Z TIENEN LOS SIGNIFICADOS YA INDICADOS; Y M ES 0 O 1, CON UN AGENTE OXIDANTE.DE APLICACION COMO COMPUESTOS INTERMEDIOS EN LA PRODUCCION DE ANTIBIOTICOS CON ACTIVIDAD INHIBIDORA DE B-LACTAMASAS.
ES518969A 1981-03-23 1983-01-13 Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico. Granted ES518969A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/246,453 US4419284A (en) 1981-03-23 1981-03-23 Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide

Publications (2)

Publication Number Publication Date
ES8403131A1 true ES8403131A1 (es) 1984-03-01
ES518969A0 ES518969A0 (es) 1984-03-01

Family

ID=22930753

Family Applications (2)

Application Number Title Priority Date Filing Date
ES510654A Expired ES8305767A1 (es) 1981-03-23 1982-03-22 Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico.
ES518969A Granted ES518969A0 (es) 1981-03-23 1983-01-13 Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES510654A Expired ES8305767A1 (es) 1981-03-23 1982-03-22 Un procedimiento para la preparacion de derivados de 1,1-dioxido del acido penicilanico.

Country Status (19)

Country Link
US (1) US4419284A (es)
EP (1) EP0061315A1 (es)
JP (1) JPS57169486A (es)
KR (1) KR830009112A (es)
AR (1) AR231292A1 (es)
AU (1) AU527896B2 (es)
CS (1) CS228919B2 (es)
DK (1) DK127082A (es)
ES (2) ES8305767A1 (es)
FI (1) FI820994A7 (es)
GB (1) GB2095667A (es)
GR (1) GR76480B (es)
IL (1) IL65307A0 (es)
NO (1) NO820899L (es)
PH (1) PH17749A (es)
PL (2) PL235579A1 (es)
PT (1) PT74620B (es)
YU (1) YU62082A (es)
ZA (1) ZA821902B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT76527B (en) * 1982-04-19 1985-12-09 Gist Brocades Nv A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof
US5266693A (en) * 1982-04-19 1993-11-30 Gist-Brocades N.V. 6-diazo-penicillanic acid 1,1-dioxide derivatives
PH20068A (en) * 1982-12-06 1986-09-18 Pfizer Process and intermediates for sultamicillin and analogs
EP0139048A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US5015473A (en) * 1984-01-30 1991-05-14 Pfizer Inc. 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
EP0262202B1 (en) * 1986-04-10 1992-07-01 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Method for preparing penicillanic acid derivatives
KR910009271B1 (ko) * 1989-06-20 1991-11-08 김영설 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
ES2039299B1 (es) * 1991-10-04 1994-05-16 Asturpharma S A Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.
ES2100125B1 (es) * 1995-06-02 1998-04-01 Asturpharma S A Procedimiento de preparacion de esteres de metanodiol de acido dioxopenicilanico.
IT202000031070A1 (it) 2020-12-16 2022-06-16 Paolo Bonomi Procedimento di sintesi di derivati ammidici dell’acido 8-idrossi penicillanico

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996235A (en) * 1974-02-19 1976-12-07 Beecham Group Limited 6-Isocyanato-6-substituted penicillins
IN149747B (es) * 1977-06-07 1982-04-03 Pfizer
JPS6056160B2 (ja) * 1977-06-07 1985-12-09 フアイザ−・インコ−ポレ−テツド β−ラクタマ−ゼ阻害剤としてのペニシラン酸１，１−ジオキシド
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
US4224951A (en) * 1978-11-30 1980-09-30 Hasson Harrith M Gynecological instrument
US4203992A (en) * 1978-12-11 1980-05-20 E. R. Squibb & Sons, Inc. β-Bromopenicillanic acid sulfone
EP0013617B1 (en) * 1979-01-10 1984-07-04 Beecham Group Plc Penicillin derivatives, process for their preparation and pharmaceutical compositions containing certain of these compounds
JPS5598186A (en) * 1979-01-10 1980-07-25 Beecham Group Ltd Manufacture of penicillin derivative
BE881675A (fr) * 1979-02-13 1980-08-12 Leo Pharm Prod Ltd B-lactames derives de l'acide penicillanique leur preparation et leurs utilisations therapeutiques
IE49880B1 (en) 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
ZA80646B (en) 1979-03-05 1981-02-25 Pfizer Process and intermediates for penicillanic acid,1,1-dioxide and esters thereof

Also Published As

Publication number Publication date
PL239642A1 (en) 1983-08-15
US4419284A (en) 1983-12-06
GR76480B (es) 1984-08-10
FI820994L (fi) 1982-09-24
PT74620B (en) 1984-11-26
PT74620A (en) 1982-04-01
PL235579A1 (en) 1983-06-06
ES510654A0 (es) 1983-04-16
ES8305767A1 (es) 1983-04-16
CS228919B2 (en) 1984-05-14
AR231292A1 (es) 1984-10-31
AU527896B2 (en) 1983-03-31
NO820899L (no) 1982-09-24
YU62082A (en) 1985-03-20
JPS57169486A (en) 1982-10-19
EP0061315A1 (en) 1982-09-29
ZA821902B (en) 1983-01-26
GB2095667A (en) 1982-10-06
ES518969A0 (es) 1984-03-01
IL65307A0 (en) 1982-05-31
FI820994A7 (fi) 1982-09-24
KR830009112A (ko) 1983-12-17
AU8176382A (en) 1982-11-04
PH17749A (en) 1984-11-27
DK127082A (da) 1982-09-24

Similar Documents

Publication Publication Date Title
IT1096381B (it) 1,1-diossidi dell'acido penicillanico come inibitori di beta-lattamasi
ES491787A0 (es) Proceso de fabricacion de derivados del acido 3-aminopropa- nosulfonico
HUT35659A (en) Process for producing 4-amino-methylene-chromane- and-chromene-derivatives and pharmaceutical compositions containing them as active agents
ES8607295A1 (es) Derivados de b-lactama
IT8047619A0 (it) Derivati di acido 6-alchil-1,2diidro-2-ossonicotinico dotati di attivita' antiiperglicemica
ES8707723A1 (es) Un procedimiento para la preparacion de derivados de 1,5-benzotiazepina
ES8503676A1 (es) Procedimiento de producir derivados de acido oxazolacetico
ES8405391A1 (es) Un procedimiento para la preparacion de un derivado de tetrahidro-1h-piridoindol.
BR8001999A (pt) Processo para a producao de derivados de amida de acido 1,2,3-tiadiazol-5-carboxilico, e composicoes com acao herbicida, reguladora do desenvolvimento e desfolhadora bem como fungicida contendo os mesmos
ATE33390T1 (de) Antibiotikum, dessen herstellung sowie dessen verwendung.
ES2061556T3 (es) Derivados amida y su produccion y fungicidas agricolas que los contienen.
IT7852196A0 (it) Procedimento per la produzione di acido 3,4-metilendiossimandelico
ES8103094A1 (es) Un procedimiento para la preparacion de 1,1-dioxido de acidopenicilanico y esteres del mismo
ES8705440A1 (es) Un procedimiento para la produccion de 2h-imidazo-(1',2':1,2)-pirrolo-(3,4-b)-piridinas
IT8025223A0 (it) Procedimento per la produzione di derivati dell'acido penicillanico.
ES8403132A1 (es) Un procedimiento para la preparacion de bis-esteres de metanodiol.
IT7950547A0 (it) Procedimento per la produzione di acido di-n-protilacetico
ES8706112A1 (es) Un procedimiento para preparar derivados de 4 4-dialquil- -2-azetidinomas
ES8200689A1 (es) Un procedimiento para la produccion de analogos de cefalosporina.
AR220710A1 (es) Nuevos derivados de n-(2-oxoperhidro-3-furil)-anilidas del acido ciclopropanocarboxilico;composiciones fungicidas que contienen estos compuestos,y procedimientos para producirlos
ES8801258A1 (es) Un procedimiento para preparar 5-(4-piridil)-6-fenil-2.3-dihidroimidazo-(2,1-b)-tiazolez y-tiazinas.
IT7848785A0 (it) Processo per il microincapsulamento di prodotti chimici agrari contenenti derivati dell'acido fosforico
IT1106801B (it) Procedimento per la produzione di derivati di acido clavulanico
ES449991A1 (es) Procedimiento para la preparacion de derivados de acido 7 (alfaamino-omega-(2,3-metilenodioxifenil y acilamido) cefa- losporanico.
AR210746A1 (es) Un metodo para la preparacion de un compuesto derivado del acido 6-(2-aminometilfenilacetamido)penicilanico particularmente util como agente terapeutico antibiotico