ES8406846A1 - Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(alquil-piperazinil)-3-quinolincarboxilicos - Google Patents

Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(alquil-piperazinil)-3-quinolincarboxilicos

Info

Publication number: ES8406846A1
Authority: ES; Spain
Prior art keywords: cyclopropyl; oxo; alkyl; quinoline; dihydro
Prior art date: 1982-12-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES528495A

Other languages

English (en)

Spanish (es)

Other versions

ES528495A0 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-29

Filing date

1983-12-28

Publication date

1984-09-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6182078&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8406846(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1983-12-28 Application filed by Bayer AG filed Critical Bayer AG

1984-09-01 Publication of ES528495A0 publication Critical patent/ES528495A0/es

1984-09-01 Publication of ES8406846A1 publication Critical patent/ES8406846A1/es

Status Expired legal-status Critical Current

Links

239000003242 anti bacterial agent Substances 0.000 title 1
239000002253 acid Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
241000588921 Enterobacteriaceae Species 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
239000000370 acceptor Substances 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
239000011630 iodine Substances 0.000 abstract 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

ES528495A 1982-12-29 1983-12-28 Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(alquil-piperazinil)-3-quinolincarboxilicos Expired ES8406846A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19823248506 DE3248506A1 (de)	1982-12-29	1982-12-29	1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number	Publication Date
ES528495A0 ES528495A0 (es)	1984-09-01
ES8406846A1 true ES8406846A1 (es)	1984-09-01

Family

ID=6182078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES528495A Expired ES8406846A1 (es)	1982-12-29	1983-12-28	Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(alquil-piperazinil)-3-quinolincarboxilicos

Country Status (20)

Country	Link
US (1)	US4544658A (2)
EP (1)	EP0113093B1 (2)
JP (1)	JPS59130880A (2)
KR (2)	KR870000901B1 (2)
AT (1)	ATE19877T1 (2)
AU (1)	AU560153B2 (2)
CA (1)	CA1218070A (2)
DD (1)	DD216016A5 (2)
DE (2)	DE3248506A1 (2)
DK (1)	DK160989C (2)
ES (1)	ES8406846A1 (2)
FI (1)	FI79102C (2)
GR (1)	GR79445B (2)
HU (1)	HU191392B (2)
IE (1)	IE56460B1 (2)
IL (1)	IL70539A (2)
NO (1)	NO162236C (2)
NZ (1)	NZ206705A (2)
PH (3)	PH20545A (2)
ZA (1)	ZA839646B (2)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3420743A1 (de) *	1984-06-04	1985-12-05	Bayer Ag, 5090 Leverkusen	7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420770A1 (de) *	1984-06-04	1985-12-05	Bayer Ag, 5090 Leverkusen	1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US5468861A (en) *	1984-06-04	1995-11-21	Bayer Aktiengesellschaft	8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420798A1 (de) *	1984-06-04	1985-12-05	Bayer Ag, 5090 Leverkusen	7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3426483A1 (de) *	1984-07-18	1986-01-30	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von halogenierten chinoloncarbonsaeuren
DE3435392A1 (de) *	1984-09-27	1986-04-03	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoesaeure
JPS6191183A (ja) *	1984-10-11	1986-05-09	Kyorin Pharmaceut Co Ltd	キノロンカルボン酸誘導体
US4636506A (en) *	1984-12-06	1987-01-13	Pfizer, Inc.	7-heterocyclic-1,4-dihydroquinolones
JPS6212760A (ja) *	1984-12-14	1987-01-21	Dai Ichi Seiyaku Co Ltd	１−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体
DE3508816A1 (de) *	1985-01-10	1986-07-10	Bayer Ag, 5090 Leverkusen	6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
DE3509546A1 (de) *	1985-03-16	1986-09-25	Bayer Ag, 5090 Leverkusen	7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU594983B2 (en)	1985-10-29	1990-03-22	Dainippon Pharmaceutical Co. Ltd.	Novel quinoline derivatives and processes for preparation thereof
DE3617803A1 (de) *	1985-11-07	1987-11-19	Bayer Ag	Verwendung von gyrasehemmern zur dekontamination von mycoplasma-infizierten zellkulturen
DE3542002A1 (de) *	1985-11-28	1987-06-04	Bayer Ag	1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4977154A (en) *	1985-12-12	1990-12-11	Warner-Lambert Company	5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
US5210193A (en) *	1986-01-17	1993-05-11	American Cyanamid Company	Piperazine derivatives
US4940710A (en) *	1986-01-17	1990-07-10	American Cyanamid Company	7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
DE3705621C2 (de) *	1986-02-25	1997-01-09	Otsuka Pharma Co Ltd	Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) *	1986-03-17	1987-09-22	Kyorin Pharmaceut Co Ltd	キノロンカルボン酸誘導体
US5164392A (en) *	1987-10-16	1992-11-17	Dainippon Pharmaceutical Co., Ltd.	Quinoline derivatives and antibacterial agent containing them
IL88003A (en) *	1987-10-16	1992-11-15	Dainippon Pharmaceutical Co	Quinoline derivatives,their preparation and pharmaceutical compositions containing them
CA2194435A1 (en) *	1994-07-18	1996-02-01	Ube Industries, Ltd.	Trifluoromethylquinolinecarboxylic acid derivative
JP3449658B2 (ja) *	1994-12-21	2003-09-22	杏林製薬株式会社	安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
US6387928B1 (en)	1997-09-15	2002-05-14	The Procter & Gamble Co.	Antimicrobial quinolones, their compositions and uses
ES2321042T3 (es) *	1997-09-15	2009-06-01	THE PROCTER & GAMBLE COMPANY	Quinolonas antimicrobianas, composiciones y usos de las mismas.
KR100821894B1 (ko) *	2004-07-02	2008-04-16	주식회사 코오롱	항균 염료 및 그를 이용한 항균 섬유
PL2001862T3 (pl) *	2006-03-28	2011-09-30	Warner Chilcott Co Llc	Jabłczany oraz odmiany polimorficzne kwasu (3S,5S)-7-[3-amino-5-metylo-piperydynylo]-1-cyklopropylo-1,4-dihydro-8-metoksy-4-okso-3-chinolinokarboksylowego
WO2007110835A2 (en) *	2006-03-28	2007-10-04	The Procter & Gamble Company	A coupling process for preparing quinolone intermediates
EP1999106B1 (en) *	2006-03-28	2012-06-27	TaiGen Biotechnology Co., Ltd.	A hydride reduction process for preparing quinolone intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3149104A (en) *	1961-01-03	1964-09-15	Sterling Drug Inc	4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
DE2808070A1 (de) *	1978-02-24	1979-08-30	Bayer Ag	Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
DE3033157A1 (de) *	1980-09-03	1982-04-01	Bayer Ag, 5090 Leverkusen	7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3142854A1 (de) *	1981-10-29	1983-05-11	Bayer Ag, 5090 Leverkusen	1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

1982
- 1982-12-29 DE DE19823248506 patent/DE3248506A1/de not_active Withdrawn
1983
- 1983-12-09 US US06/560,027 patent/US4544658A/en not_active Expired - Lifetime
- 1983-12-15 NO NO834632A patent/NO162236C/no unknown
- 1983-12-17 AT AT83112725T patent/ATE19877T1/de active
- 1983-12-17 DE DE8383112725T patent/DE3363608D1/de not_active Expired
- 1983-12-17 EP EP83112725A patent/EP0113093B1/de not_active Expired
- 1983-12-19 AU AU22510/83A patent/AU560153B2/en not_active Ceased
- 1983-12-22 IE IE3034/83A patent/IE56460B1/en not_active IP Right Cessation
- 1983-12-23 CA CA000444233A patent/CA1218070A/en not_active Expired
- 1983-12-23 NZ NZ206705A patent/NZ206705A/en unknown
- 1983-12-26 IL IL70539A patent/IL70539A/xx not_active IP Right Cessation
- 1983-12-27 GR GR73353A patent/GR79445B/el unknown
- 1983-12-27 FI FI834806A patent/FI79102C/fi not_active IP Right Cessation
- 1983-12-27 JP JP58244937A patent/JPS59130880A/ja active Granted
- 1983-12-27 PH PH30028A patent/PH20545A/en unknown
- 1983-12-28 DD DD83258781A patent/DD216016A5/de not_active IP Right Cessation
- 1983-12-28 DK DK604083A patent/DK160989C/da active
- 1983-12-28 HU HU834499A patent/HU191392B/hu not_active IP Right Cessation
- 1983-12-28 ZA ZA839646A patent/ZA839646B/xx unknown
- 1983-12-28 ES ES528495A patent/ES8406846A1/es not_active Expired
- 1983-12-29 KR KR1019830006264A patent/KR870000901B1/ko not_active Expired
1985
- 1985-02-14 PH PH31853A patent/PH21478A/en unknown
- 1985-02-14 PH PH31853A patent/PH22453A/en unknown
1987
- 1987-03-28 KR KR1019870002888A patent/KR870001003B1/ko not_active Expired

Also Published As

Publication number	Publication date
ATE19877T1 (de)	1986-06-15
GR79445B (2)	1984-10-30
ES528495A0 (es)	1984-09-01
IL70539A (en)	1987-08-31
CA1218070A (en)	1987-02-17
DK160989C (da)	1991-10-28
PH21478A (en)	1987-10-28
AU560153B2 (en)	1987-04-02
PH22453A (en)	1988-09-12
DE3248506A1 (de)	1984-07-05
EP0113093B1 (de)	1986-05-21
NO162236C (no)	1989-11-29
NO834632L (no)	1984-07-02
DD216016A5 (de)	1984-11-28
NO162236B (no)	1989-08-21
EP0113093A1 (de)	1984-07-11
FI79102B (fi)	1989-07-31
PH20545A (en)	1987-02-09
NZ206705A (en)	1986-01-24
JPS59130880A (ja)	1984-07-27
DE3363608D1 (en)	1986-06-26
HU191392B (en)	1987-02-27
FI79102C (fi)	1989-11-10
IL70539A0 (en)	1984-03-30
AU2251083A (en)	1984-07-05
KR870001003B1 (ko)	1987-05-18
IE833034L (en)	1984-06-29
KR870000901B1 (ko)	1987-05-04
ZA839646B (en)	1984-08-29
FI834806A0 (fi)	1983-12-27
DK160989B (da)	1991-05-13
US4544658A (en)	1985-10-01
JPH0323549B2 (2)	1991-03-29
IE56460B1 (en)	1991-08-14
DK604083D0 (da)	1983-12-28
FI834806L (fi)	1984-06-30
DK604083A (da)	1984-06-30
KR840006990A (ko)	1984-12-04

Legal Events

Date	Code	Title	Description
2002-06-01	FD1A	Patent lapsed	Effective date: 20020506

Publication	Publication Date	Title
ES8104300A1 (es)	1981-04-01	Un procedimiento para la preparacion de nuevos bis-esteres de metanodiol.
FR2453148A1 (fr)	1980-10-31	Nouveaux derives arylsulfinyle d'acide acetohydroxamique, leur procede de preparation et leur application en therapeutique
SE7908065L (sv)	1980-03-30	Substituerade kinolinkarboxylsyraderivat
DK160989C (da)	1991-10-28	1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(alkylsubstitueret 1-piperazinyl)-3-quinolincarboxylsyrer og farmaceutisk anvendelse syreadditions-, alkalimetal- og jordalkalimetalsalte og hydrater deraf, disse forbindelser til behandling af bakterielle sygdomme samt antibakterielle midler indeholdende disse forbindelser
FR2359144A1 (fr)	1978-02-17	Sels de l'acide clavulanique utilisable comme medicaments
SE8900828D0 (sv)	1989-03-09	Antivirala och immunstimulerande farmaceutiska kompositioner samt foerfarande foer framstaellning av desamma
GR3021014T3 (en)	1996-12-31	2-Substituted quinolines, process for their preparation as well as their use in medicaments
HUT40126A (en)	1986-11-28	Process for producing 6,7-disubstituted-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtiridine-3-carboxylic acid derivatives and pharmaceutical compositions and food additives containing them
DE3363607D1 (en)	1986-06-26	1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(oxoalkyl)-1-piperazinyl)-3-quinoline-carboxylic acids and their derivatives, process for their preparation and antibacterial agents containing them
FR2433504A1 (fr)	1980-03-14	Procede de preparation de derives du biphenyle
FR2394546A1 (fr)	1979-01-12	Nouveaux derives de 1,2,3,4,6,7-hexahydro-11bah-benzo(a)-quinolizine, leur preparation et leur application en tant que medicaments
ES8502688A1 (es)	1985-01-16	Procedimiento para preparar derivados de quinolina
FR2457294A1 (fr)	1980-12-19	Derives de l'acide penicillanique utiles comme medicaments, compositions therapeutiques les contenant et procedes de leur preparation
FR2559484B2 (fr)	1986-09-26	Nouveau derive 7-(pyrrol-1-yl) de l'acide 1-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridin)-3-carboxylique, sa preparation et son application en tant que medicament
SE7810295L (sv)	1979-10-20	Substituerad kinolinkarboxylsyra
ES8700669A1 (es)	1986-11-16	Procedimiento de preparar derivados penam y sus sales
ATE10735T1 (de)	1984-12-15	Verfahren zur herstellung von chinonderivaten.
FR2426467A1 (fr)	1979-12-21	Composes de type acide p-aminobenzoique-n-l-rhamnoside utiles comme medicaments
MA19842A1 (fr)	1984-04-01	Procede de preparation de derives de peneme antibacteriens .
FI79544B (fi)	1989-09-29	Foerfarande foer framstaellning av primycinsalter.
ES8201169A1 (es)	1981-12-01	Un procedimiento para la preparacion de derivados de quina- zolina
FR2361341A1 (fr)	1978-03-10	Procede de preparation d'esters de l'acide anthranilique
FR2429211A1 (fr)	1980-01-18	Procede de production de derives de n-methylbenzothiazolone substitues en position 4
ES8706122A1 (es)	1987-06-01	Un procedimiento para la preparacion de agentes inotropicos de quinolona
FR2433009A1 (fr)	1980-03-07	Procede pour la preparation de dicyclopentylene(2,2'-bis(4-alkyl-6-t-butylphenols))