ES8501378A1 - Procedimiento de preparar derivados de n-cicloalcoilmetil-2 oxo-3 diaril 5-6 as triacina - Google Patents

Procedimiento de preparar derivados de n-cicloalcoilmetil-2 oxo-3 diaril 5-6 as triacina

Info

Publication number
ES8501378A1
ES8501378A1 ES531447A ES531447A ES8501378A1 ES 8501378 A1 ES8501378 A1 ES 8501378A1 ES 531447 A ES531447 A ES 531447A ES 531447 A ES531447 A ES 531447A ES 8501378 A1 ES8501378 A1 ES 8501378A1
Authority
ES
Spain
Prior art keywords
oxo
formula
diparamethoxyphenyl
triazines
cyclopropylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531447A
Other languages
English (en)
Other versions
ES531447A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Publication of ES531447A0 publication Critical patent/ES531447A0/es
Publication of ES8501378A1 publication Critical patent/ES8501378A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE N-CICLOALCOHILMETIL-2-OXO-3-DIARIL-5,6 AS TRIACINA, DE FORMULA (I), EN LA QUE AR PUEDE SER UNO DE VARIOS RADICALES Y N VALE 1-4.CONSISTE EN LA REACCION DE UNA OXO-3-DIARIL-5,6 AS TRIACINA, DE FORMULA (II), CON UN AGENTE SODANTE EN UN DISOLVENTE ORGANICO, SEGUIDA DE LA CONDENSACION CON UN HALOGENURO DE METILCICLOALCOILO, DE FORMULA (III), EN LAS CUALES X ES UN HALOGENO, Y AR Y N SON LOS MISMOS QUE EN LA FORMULA (I).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LAS ALGIAS REBELDES Y DE LAS MIGRAN/AS.
ES531447A 1983-04-14 1984-04-10 Procedimiento de preparar derivados de n-cicloalcoilmetil-2 oxo-3 diaril 5-6 as triacina Expired ES8501378A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8306107A FR2544313B1 (fr) 1983-04-14 1983-04-14 Les n-cycloalcoyl methyl-2 oxo-3 diaryl 5-6 as triazines, leur procede de fabrication et leur utilisation en tant que medicament

Publications (2)

Publication Number Publication Date
ES531447A0 ES531447A0 (es) 1984-12-16
ES8501378A1 true ES8501378A1 (es) 1984-12-16

Family

ID=9287851

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531447A Expired ES8501378A1 (es) 1983-04-14 1984-04-10 Procedimiento de preparar derivados de n-cicloalcoilmetil-2 oxo-3 diaril 5-6 as triacina

Country Status (10)

Country Link
US (1) US4511566A (es)
EP (1) EP0123605B1 (es)
JP (1) JPS59199682A (es)
AT (1) ATE23330T1 (es)
AU (1) AU565187B2 (es)
CA (1) CA1209145A (es)
DE (1) DE3461187D1 (es)
ES (1) ES8501378A1 (es)
FR (1) FR2544313B1 (es)
ZA (1) ZA842769B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2592878B1 (fr) * 1986-01-16 1988-12-16 Pf Medicament Monoaryl-5 as triazinones-3 substituees en position 2, leur procede de preparation et leur application en tant que medicaments
EP0442448A3 (en) 1990-02-13 1992-08-12 Bristol-Myers Squibb Company Heterocyclic carboxylic acids and esters
US5021415A (en) * 1990-02-13 1991-06-04 Bristol-Myers Squibb Co. Triazine carboxylic acids and esters
EP3085695A1 (en) * 2013-12-17 2016-10-26 Nissan Chemical Industries, Ltd. Substituted triazinone compound and t-type calcium channel inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368278A1 (fr) * 1976-10-25 1978-05-19 Fabre Sa Pierre Nouveaux medicaments antalgiques contenant des triazines 1-2-4
DE2810052A1 (de) * 1977-03-09 1978-09-14 Fabre Sa Pierre Aminoaryl-1,2,4-triazine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
FR2383176A1 (fr) * 1977-03-09 1978-10-06 Fabre Sa Pierre Amino aryl triazines 1-2-4 utilisables dans le traitement d'algies diverses
FR2478095A1 (fr) * 1980-03-14 1981-09-18 Fabre Sa Pierre Derives cetoniques de diaryl 5-6 triazines 1-2-4 antalgiques et antiagregants utilisables dans le traitement de fond des migraines
FR2500830A1 (fr) * 1981-03-02 1982-09-03 Fabre Sa Pierre Diaryl as-triazines fonctionnalisees en 2, leur procede de preparation et leur utilisation comme medicaments

Also Published As

Publication number Publication date
EP0123605B1 (fr) 1986-11-05
AU2670284A (en) 1984-10-18
ES531447A0 (es) 1984-12-16
EP0123605A1 (fr) 1984-10-31
DE3461187D1 (en) 1986-12-11
ZA842769B (en) 1984-11-28
US4511566A (en) 1985-04-16
ATE23330T1 (de) 1986-11-15
JPS59199682A (ja) 1984-11-12
FR2544313B1 (fr) 1985-08-09
CA1209145A (fr) 1986-08-05
AU565187B2 (en) 1987-09-10
FR2544313A1 (fr) 1984-10-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603