ES8501410A1 - Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de fosfolipidos.

Info

Publication number
ES8501410A1
ES8501410A1 ES524610A ES524610A ES8501410A1 ES 8501410 A1 ES8501410 A1 ES 8501410A1 ES 524610 A ES524610 A ES 524610A ES 524610 A ES524610 A ES 524610A ES 8501410 A1 ES8501410 A1 ES 8501410A1
Authority
ES
Spain
Prior art keywords
preparation
processes
same
pharmaceutical composition
phospholipid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524610A
Other languages
English (en)
Other versions
ES524610A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8501410A1 publication Critical patent/ES8501410A1/es
Publication of ES524610A0 publication Critical patent/ES524610A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE FOSFOLIPIDOS, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN SOMETER A UNA REACCION DE ELIMINACION DE LOS GRUPOS PROTECTORES, A UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R REPRESENTA ALCOXI INFERIOR O UN GRUPO (ALICICLICO INFERIOR) OXI QUE ESTA SUSTITUIDO CON DOS O MAS GRUPOS HIDROXI O HIDROXI PROTEGIDO.DE APLICACION EN FARMACIA PARA LA PREPARACION DE COMPOSICIONES UTILIZADAS EN EL TRATAMIENTO TERAPEUTICO DEL CANCER.
ES524610A 1982-07-30 1983-07-29 Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. Granted ES524610A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8222020 1982-07-30

Publications (2)

Publication Number Publication Date
ES8501410A1 true ES8501410A1 (es) 1984-12-01
ES524610A0 ES524610A0 (es) 1984-12-01

Family

ID=10532013

Family Applications (3)

Application Number Title Priority Date Filing Date
ES524610A Granted ES524610A0 (es) 1982-07-30 1983-07-29 Un procedimiento para la preparacion de nuevos derivados de fosfolipidos.
ES530669A Expired ES8602027A1 (es) 1982-07-30 1984-03-15 Un procedimiento para la preparacion de nuevos derivados de fosfolipidos
ES530668A Granted ES530668A0 (es) 1982-07-30 1984-03-15 Un procedimiento para la preparacion de nuevos derivados de fosfolipidos

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES530669A Expired ES8602027A1 (es) 1982-07-30 1984-03-15 Un procedimiento para la preparacion de nuevos derivados de fosfolipidos
ES530668A Granted ES530668A0 (es) 1982-07-30 1984-03-15 Un procedimiento para la preparacion de nuevos derivados de fosfolipidos

Country Status (6)

Country Link
US (1) US4585762A (es)
EP (1) EP0100499A3 (es)
JP (1) JPS5942394A (es)
KR (1) KR840005464A (es)
DK (1) DK347383A (es)
ES (3) ES524610A0 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239817A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue glycerinderivate zur synthese von phospholipiden
JPS6122096A (ja) * 1984-07-09 1986-01-30 Kao Corp 糖リン酸エステルおよびその製造方法
IT1244546B (it) * 1991-02-01 1994-07-15 Mediolanum Farmaceutici Spa Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica
JP2553171Y2 (ja) * 1991-05-31 1997-11-05 東陶機器株式会社 便器装置
SE9102068L (sv) * 1991-07-03 1993-01-04 Perstorp Ab Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav
IT1255476B (it) * 1992-07-30 1995-11-02 Glicerofosfoderivati farmacologicamente attivi
DE4234130A1 (de) * 1992-10-09 1994-04-14 Max Planck Gesellschaft Phospholipase A¶2¶ inhibierende Phosphatidylcholinverbindungen
US5354853A (en) * 1993-03-12 1994-10-11 Genzyme Corporation Phospholipid-saccharide conjugates
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
CN1132586C (zh) 1993-09-09 2003-12-31 罗拉斯医疗公司 来自胆汁的免疫调节组合物、其制备方法及其用途
BR9607967A (pt) 1995-03-16 1998-01-13 Imutec Pharma Inc Uso de composições imunomodulares extraídas da bile para o tratamento das desordens do sistema imunológico fabricação do medicamento e emprego do mesmo
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
EP1332149B1 (en) * 2000-11-07 2005-11-02 I.R.B. Istituto Di Ricerche Biotecnologiche S.r.l. Glycerophosphoinositol derivatives as modulators of cytosolic a2 phospholipase
US7378403B2 (en) * 2002-09-03 2008-05-27 The United States Of America As Represented By The Department Of Health And Human Services Akt inhibitors, pharmaceutical compositions, and uses thereof
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2287901A1 (fr) * 1974-10-14 1976-05-14 Pasteur Institut Medicament immunostimulant contenant un derive d'ose ou de polyose phosphoryle
DE2659048A1 (de) * 1976-12-27 1978-07-06 Nattermann A & Cie Neue inositphosphatid-derivate und verfahren zur herstellung dieser verbindungen

Also Published As

Publication number Publication date
JPS5942394A (ja) 1984-03-08
KR840005464A (ko) 1984-11-12
EP0100499A2 (en) 1984-02-15
ES524610A0 (es) 1984-12-01
ES8604243A1 (es) 1985-07-01
EP0100499A3 (en) 1985-06-12
US4585762A (en) 1986-04-29
ES530669A0 (es) 1985-05-01
DK347383D0 (da) 1983-07-28
ES8602027A1 (es) 1985-05-01
DK347383A (da) 1984-01-31
ES530668A0 (es) 1985-07-01

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