ES8501774A1 - Un metodo de preparar derivados de metaloceno marcados con isotopos radiactivos. - Google Patents

Un metodo de preparar derivados de metaloceno marcados con isotopos radiactivos.

Info

Publication number
ES8501774A1
ES8501774A1 ES527186A ES527186A ES8501774A1 ES 8501774 A1 ES8501774 A1 ES 8501774A1 ES 527186 A ES527186 A ES 527186A ES 527186 A ES527186 A ES 527186A ES 8501774 A1 ES8501774 A1 ES 8501774A1
Authority
ES
Spain
Prior art keywords
group
metallochene
preparing
radioactive isotopes
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527186A
Other languages
English (en)
Other versions
ES527186A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Byk Mallinckrodt CIL BV
Original Assignee
Byk Mallinckrodt CIL BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Mallinckrodt CIL BV filed Critical Byk Mallinckrodt CIL BV
Publication of ES8501774A1 publication Critical patent/ES8501774A1/es
Publication of ES527186A0 publication Critical patent/ES527186A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0487—Metallocenes, i.e. complexes based on a radioactive metal complexed by two cyclopentadienyl anions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE MATCLOCENO MARCADOS CON ISOTOPOS RADIACTIVOS, DE FORMULA (I), EN LA QUE MC ES UN METALOCENILO CON UN ATOMO CENTRAL RADIACTIVO; R Y R1 PUEDEN SER VARIOS RADICALES; Y N VALE 1-4.CONSISTE EN LA REACCION DE UN DERIVADO DE METALOCENO NO RADIACTIVO CON UN COMPUESTO METALICO RADIACTIVO, EN UN DISOLVENTE ORGANICO POLAR TAL COMO ETANOL O DIMETILFORMAMIDA, A TEMPERATURA ENTRE 30JC Y 250JC.ESTOS COMPUESTOS TIENEN APLICACIONES EN COMPOSICIONES PARA RADIODIAGNOSTICO, EN ESPECIAL EN EL EXAMEN DE LA FUNCION RENAL.
ES527186A 1982-12-01 1983-11-11 Un metodo de preparar derivados de metaloceno marcados con isotopos radiactivos. Granted ES527186A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823244886 DE3244886A1 (de) 1982-12-01 1982-12-01 Metallocen-derivate der aminosaeuren glycin und alanin mit radioaktivem zentralatom als radiopharmaka.

Publications (2)

Publication Number Publication Date
ES8501774A1 true ES8501774A1 (es) 1984-12-01
ES527186A0 ES527186A0 (es) 1984-12-01

Family

ID=6179788

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527186A Granted ES527186A0 (es) 1982-12-01 1983-11-11 Un metodo de preparar derivados de metaloceno marcados con isotopos radiactivos.

Country Status (6)

Country Link
US (1) US4584186A (es)
EP (1) EP0113135A3 (es)
JP (1) JPS59152395A (es)
AU (1) AU2112383A (es)
DE (1) DE3244886A1 (es)
ES (1) ES527186A0 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894445A (en) * 1985-08-05 1990-01-16 E. I. Du Pont De Nemours And Company Metal-isonitrile adducts for preparing radionuclide complexes
JPH06501450A (ja) * 1990-06-01 1994-02-17 インスティトゥート　フュア　ディアグノスティックフォルシュング　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング　アン　デア　フライエン　ウニヴェルジテート　ベルリン シクロペンタジエニルカルボニル―９９ｍＴｃ錯体、その製造法および診断学への該化合物の使用
GB2492135B (en) 2011-06-23 2013-12-04 Rolls Royce Plc A heat treatment apparatus and a method of using such apparatus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2246460A1 (de) * 1972-09-21 1974-04-04 Schering Ag Metallocene und metallocen-derivate mit radioaktivem zentralatom

Also Published As

Publication number Publication date
EP0113135A2 (en) 1984-07-11
EP0113135A3 (en) 1986-01-29
AU2112383A (en) 1984-06-07
DE3244886A1 (de) 1984-06-07
JPS59152395A (ja) 1984-08-31
ES527186A0 (es) 1984-12-01
US4584186A (en) 1986-04-22

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