ES8501775A1 - Procedimiento para preparar productos estratrienicos marcados con yodo 125 o 131 - Google Patents
Procedimiento para preparar productos estratrienicos marcados con yodo 125 o 131Info
- Publication number
- ES8501775A1 ES8501775A1 ES527948A ES527948A ES8501775A1 ES 8501775 A1 ES8501775 A1 ES 8501775A1 ES 527948 A ES527948 A ES 527948A ES 527948 A ES527948 A ES 527948A ES 8501775 A1 ES8501775 A1 ES 8501775A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- antigens
- iodine
- intermediates
- radioimmuno assays
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002285 radioactive effect Effects 0.000 title abstract 2
- 150000002164 estratrienes Chemical class 0.000 title 1
- 238000003127 radioimmunoassay Methods 0.000 title 1
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical compound [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 abstract 2
- 229940044173 iodine-125 Drugs 0.000 abstract 2
- MPQOWLNEPUIIBZ-SQNIBIBYSA-N (8s,13s,14s)-13-methyl-1,2,3,6,7,8,14,15,16,17-decahydrocyclopenta[a]phenanthrene Chemical class C1CC2=CCCCC2=C2[C@@H]1[C@@H]1CCC[C@@]1(C)C=C2 MPQOWLNEPUIIBZ-SQNIBIBYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS ESTRATRIENICOS MARCADOS CON YODO 125 O 131, EN FORMA DE ISOMEROS SIN O ANTI O DE SUS MEZCLAS, DE FORMULA (I), EN LA QUE R Y R1 PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I), CON UN HALURO DE CARBOXIMETOXILAMINA, EN PRESENCIA DE UNA BASE, SEGUIDA DE LA FIJACION EN LA FUNCION ACIDO DE UN GRUPO ACTIVADOR, Y REACCION CON UN AMINOACIDO ACEPTOR DE YODO MARCADO CON YODO 125 O 131.ESTOS COMPUESTOS TIENEN APLICACIONES EN DOSIFICACIONES RADIOINMUNOLOGICAS DE LAS 17BBB- Y 17BAB-HIDROXI-4,9,11-ESTRATRIEN-3-ONAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8220845A FR2537586A1 (fr) | 1982-12-13 | 1982-12-13 | Derives estratrieniques radioactifs marques a l'iode, leur procede de preparation et leur application aux dosages radio-immunologiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8501775A1 true ES8501775A1 (es) | 1984-12-01 |
| ES527948A0 ES527948A0 (es) | 1984-12-01 |
Family
ID=9280024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES527948A Granted ES527948A0 (es) | 1982-12-13 | 1983-12-12 | Procedimiento para preparar productos estratrienicos marcados con yodo 125 o 131 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4632820A (es) |
| EP (1) | EP0114011B1 (es) |
| AU (1) | AU563969B2 (es) |
| BR (1) | BR8306827A (es) |
| DE (1) | DE3367599D1 (es) |
| DK (1) | DK167767B1 (es) |
| ES (1) | ES527948A0 (es) |
| FR (1) | FR2537586A1 (es) |
| IE (1) | IE56368B1 (es) |
| NZ (1) | NZ206564A (es) |
| SU (1) | SU1299513A3 (es) |
| ZA (1) | ZA838922B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE58901057D1 (de) * | 1988-01-25 | 1992-05-07 | Boehringer Mannheim Gmbh | Neue haptenderivate und davon abgeleitete hapten-protein-konjugate. |
| FR2732115B1 (fr) * | 1995-03-24 | 1997-06-13 | Immunotech Sa | Procede de dosage immunologique du cortisol, notamment urinaire, et reactifs utilises |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2250745A1 (en) * | 1973-11-12 | 1975-06-06 | Serono Ist Farm | Reagent for radio-immunoassay of testosterone - by reacting testerone-oxime with tyrosine ester |
| AU2467477A (en) * | 1976-05-10 | 1978-11-02 | Beckman Instruments Inc | 1125 imidazole steroid derivatives |
| US4323511A (en) * | 1978-05-22 | 1982-04-06 | E. R. Squibb & Sons, Inc. | Steroid derivatives and their use in radioimmunoassays |
| GB1604864A (en) * | 1978-05-31 | 1981-12-16 | Hoechst Uk Ltd | Methods of iodinating a progesterone derivative |
| FR2437398A1 (fr) * | 1978-06-20 | 1980-04-25 | Commissariat Energie Atomique | Compose iode utilisable comme traceur en radio-immunologie |
| US4339390A (en) * | 1979-09-18 | 1982-07-13 | Abbott Laboratories | Preferential immunoreactivity of syn-isomer of cortisol derivative |
-
1982
- 1982-12-13 FR FR8220845A patent/FR2537586A1/fr active Granted
-
1983
- 1983-11-30 ZA ZA838922A patent/ZA838922B/xx unknown
- 1983-12-09 SU SU833671526A patent/SU1299513A3/ru active
- 1983-12-12 IE IE2910/83A patent/IE56368B1/en not_active IP Right Cessation
- 1983-12-12 US US06/560,184 patent/US4632820A/en not_active Expired - Lifetime
- 1983-12-12 ES ES527948A patent/ES527948A0/es active Granted
- 1983-12-12 EP EP83402389A patent/EP0114011B1/fr not_active Expired
- 1983-12-12 AU AU22314/83A patent/AU563969B2/en not_active Ceased
- 1983-12-12 DK DK569783A patent/DK167767B1/da not_active IP Right Cessation
- 1983-12-12 BR BR8306827A patent/BR8306827A/pt unknown
- 1983-12-12 DE DE8383402389T patent/DE3367599D1/de not_active Expired
- 1983-12-13 NZ NZ206564A patent/NZ206564A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0114011A1 (fr) | 1984-07-25 |
| FR2537586B1 (es) | 1985-05-03 |
| US4632820A (en) | 1986-12-30 |
| AU563969B2 (en) | 1987-07-30 |
| FR2537586A1 (fr) | 1984-06-15 |
| ZA838922B (en) | 1985-01-30 |
| NZ206564A (en) | 1987-06-30 |
| ES527948A0 (es) | 1984-12-01 |
| AU2231483A (en) | 1984-06-21 |
| BR8306827A (pt) | 1984-07-17 |
| DK167767B1 (da) | 1993-12-13 |
| DK569783D0 (da) | 1983-12-12 |
| IE56368B1 (en) | 1991-07-03 |
| IE832910L (en) | 1984-06-13 |
| EP0114011B1 (fr) | 1986-11-12 |
| DK569783A (da) | 1984-06-14 |
| DE3367599D1 (en) | 1987-01-02 |
| SU1299513A3 (ru) | 1987-03-23 |
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