ES8503672A1 - Un procedimiento para la obtencion de diazolilalquil-carbinoles sustituidos - Google Patents
Un procedimiento para la obtencion de diazolilalquil-carbinoles sustituidosInfo
- Publication number
- ES8503672A1 ES8503672A1 ES530114A ES530114A ES8503672A1 ES 8503672 A1 ES8503672 A1 ES 8503672A1 ES 530114 A ES530114 A ES 530114A ES 530114 A ES530114 A ES 530114A ES 8503672 A1 ES8503672 A1 ES 8503672A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- chain
- phenyl
- straight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001857 anti-mycotic effect Effects 0.000 title 1
- 239000002543 antimycotic Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- -1 cyano, hydroxyl Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Photoreceptors In Electrophotography (AREA)
- Luminescent Compositions (AREA)
- Photosensitive Polymer And Photoresist Processing (AREA)
- Polymerization Catalysts (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DIAZOLILALQUILCARBINOLES SUSTITUIDOS.CONSISTE EN HACER REACCIONAR AZOLILOXIRANOS DE FORMULA (II) CON AZOLES DE FORMULA (III), EN DISOLVENTES ORGANICOS INERTES, EN PRESENCIA DE BASES INORGANICAS U ORGANICAS Y A UNA TEMPERATURA ENTRE 60 Y 150JC, PARA OBTENER LOS COMPUESTOS DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE TOLERABLES. SIENDO A Y B, N O UN GRUPO CH-; X, H O ALQUILO; Y, ALQUILO, ALQUENILO, ALQUINILO Y OTROS; R, FENILO SUSTITUIDO O NO Y EL AGRUPAMIENTO DE FORMULA (IV); ALQ Y ALQ, JUNTOS UN ANILLO CICLOALIFATICO Y POR SEPARADO, ALQUILO; Y R, ALQUILO, ALQUENILO, FENILO Y OTROS.SE UTILIZAN CON ANTIMICOTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833307218 DE3307218A1 (de) | 1983-03-02 | 1983-03-02 | Substituierte diazolylalkyl-carbinole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES530114A0 ES530114A0 (es) | 1985-04-01 |
| ES8503672A1 true ES8503672A1 (es) | 1985-04-01 |
Family
ID=6192203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES530114A Expired ES8503672A1 (es) | 1983-03-02 | 1984-02-28 | Un procedimiento para la obtencion de diazolilalquil-carbinoles sustituidos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5011850A (es) |
| EP (1) | EP0120276B1 (es) |
| JP (1) | JPS59164778A (es) |
| KR (1) | KR840008020A (es) |
| AT (1) | ATE22887T1 (es) |
| AU (2) | AU561701B2 (es) |
| CA (3) | CA1245666A (es) |
| DE (2) | DE3307218A1 (es) |
| DK (1) | DK83684A (es) |
| ES (1) | ES8503672A1 (es) |
| GR (1) | GR79549B (es) |
| HU (2) | HU191254B (es) |
| IL (2) | IL71098A (es) |
| ZA (1) | ZA841552B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2062941A1 (es) * | 1993-03-15 | 1994-12-16 | Uriach & Cia Sa J | Nuevos derivados de azol activos por via oral. |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8306351D0 (en) * | 1983-03-08 | 1983-04-13 | Ici Plc | Azole fungicides |
| DK159205C (da) * | 1983-03-16 | 1991-03-04 | Pfizer | Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion |
| US4992454A (en) * | 1983-03-16 | 1991-02-12 | Pfizer Inc. | Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and derivatives thereof |
| DE3325313A1 (de) * | 1983-07-13 | 1985-01-31 | Bayer Ag, 5090 Leverkusen | Fungizide mittel, deren herstellung und verwendung |
| DE3440117A1 (de) * | 1984-11-02 | 1986-05-15 | Bayer Ag, 5090 Leverkusen | Substituierte azolylcyclopropyl-azolylmethyl-carbinol-derivate |
| DE3501370A1 (de) * | 1985-01-17 | 1986-07-17 | Bayer Ag, 5090 Leverkusen | 1-aryl-2,2-dialkyl-2-(1,2,4-triazol-1-yl)-ethanole |
| US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| DE3720756A1 (de) * | 1987-06-24 | 1989-01-05 | Bayer Ag | Azolylmethyl-cyclopropyl-carbinol-derivate |
| GB8716651D0 (en) * | 1987-07-15 | 1987-08-19 | Ici Plc | 2-propanol derivatives |
| DE3725396A1 (de) * | 1987-07-31 | 1989-02-09 | Bayer Ag | Hydroxyethyl-azolyl-oximether |
| DE3732384A1 (de) * | 1987-09-25 | 1989-04-06 | Bayer Ag | Bisazolyl-hydroxyalkyl-derivate enthaltende antimykotische mittel |
| DE3803833A1 (de) * | 1988-02-09 | 1989-08-17 | Bayer Ag | Substituierte azolylmethyloxirane |
| NO171272C (no) * | 1988-03-04 | 1993-02-17 | Sankyo Co | Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,4-triazolforbindelser |
| GB8819308D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
| GB9002375D0 (en) * | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
| EP0548553A1 (en) * | 1991-11-25 | 1993-06-30 | Takeda Chemical Industries, Ltd. | Optically active azole compounds, their production and use |
| NZ270418A (en) | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| CN109535091B (zh) * | 2018-12-04 | 2022-05-13 | 淮安国瑞化工有限公司 | 以1-(4-氯苯基)-2-(1h-1,2,4-三唑-1-基)乙酮合成环唑醇的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU557755A3 (ru) * | 1968-08-19 | 1977-05-05 | Янссен Фармасьютика Н.В. (Фирма) | Способ получени производных имидазола |
| IE44186B1 (en) * | 1975-12-03 | 1981-09-09 | Ici Ltd | 1,2,4-triazolyl alkanols and their use as pesticides |
| IT1097314B (it) * | 1978-07-26 | 1985-08-31 | Recordati Chem Pharm | Derivati dell'imidazolo ad attivita' anticonvulsivante |
| GB2078719B (en) * | 1980-06-02 | 1984-04-26 | Ici Ltd | Heterocyclic compounds |
| GB2104065B (en) * | 1981-06-04 | 1985-11-06 | Ciba Geigy Ag | Heterocyclyl-substituted mandelic acid compounds and mandelonitriles and their use for combating microorganisms |
| EP0069442B1 (en) * | 1981-06-06 | 1985-02-20 | Pfizer Limited | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
-
1983
- 1983-03-02 DE DE19833307218 patent/DE3307218A1/de not_active Withdrawn
-
1984
- 1984-02-20 DE DE8484101710T patent/DE3460971D1/de not_active Expired
- 1984-02-20 AT AT84101710T patent/ATE22887T1/de not_active IP Right Cessation
- 1984-02-20 EP EP84101710A patent/EP0120276B1/de not_active Expired
- 1984-02-21 DK DK83684A patent/DK83684A/da not_active Application Discontinuation
- 1984-02-27 AU AU25063/84A patent/AU561701B2/en not_active Ceased
- 1984-02-28 IL IL71098A patent/IL71098A/xx unknown
- 1984-02-28 JP JP59035451A patent/JPS59164778A/ja active Granted
- 1984-02-28 ES ES530114A patent/ES8503672A1/es not_active Expired
- 1984-02-29 CA CA000448581A patent/CA1245666A/en not_active Expired
- 1984-03-01 GR GR73973A patent/GR79549B/el unknown
- 1984-03-01 ZA ZA841552A patent/ZA841552B/xx unknown
- 1984-03-02 HU HU84856A patent/HU191254B/hu not_active IP Right Cessation
- 1984-03-02 KR KR1019840001059A patent/KR840008020A/ko not_active Ceased
- 1984-03-02 HU HU843946A patent/HU194189B/hu not_active IP Right Cessation
-
1986
- 1986-10-06 US US06/915,435 patent/US5011850A/en not_active Expired - Fee Related
- 1986-11-21 IL IL80726A patent/IL80726A0/xx not_active IP Right Cessation
-
1987
- 1987-02-11 AU AU69164/87A patent/AU6916487A/en not_active Abandoned
- 1987-07-07 CA CA000541542A patent/CA1249592A/en not_active Expired
- 1987-07-07 CA CA000541541A patent/CA1239409A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2062941A1 (es) * | 1993-03-15 | 1994-12-16 | Uriach & Cia Sa J | Nuevos derivados de azol activos por via oral. |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0120276A1 (de) | 1984-10-03 |
| IL71098A (en) | 1988-05-31 |
| ES530114A0 (es) | 1985-04-01 |
| JPS59164778A (ja) | 1984-09-17 |
| AU6916487A (en) | 1987-05-28 |
| IL80726A0 (en) | 1987-02-27 |
| CA1239409A (en) | 1988-07-19 |
| HU191254B (en) | 1987-01-28 |
| DK83684A (da) | 1984-09-03 |
| KR840008020A (ko) | 1984-12-12 |
| ATE22887T1 (de) | 1986-11-15 |
| ZA841552B (en) | 1984-10-31 |
| CA1249592A (en) | 1989-01-31 |
| HU194189B (en) | 1988-01-28 |
| JPH0437829B2 (es) | 1992-06-22 |
| CA1245666A (en) | 1988-11-29 |
| DE3307218A1 (de) | 1984-09-06 |
| AU2506384A (en) | 1984-09-06 |
| DK83684D0 (da) | 1984-02-21 |
| DE3460971D1 (en) | 1986-11-20 |
| EP0120276B1 (de) | 1986-10-15 |
| IL71098A0 (en) | 1984-05-31 |
| AU561701B2 (en) | 1987-05-14 |
| US5011850A (en) | 1991-04-30 |
| GR79549B (es) | 1984-10-30 |
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