ES8503952A1 - Un procedimiento para la preparacion de una vacuna contra picornavirus - Google Patents

Un procedimiento para la preparacion de una vacuna contra picornavirus

Info

Publication number
ES8503952A1
ES8503952A1 ES529298A ES529298A ES8503952A1 ES 8503952 A1 ES8503952 A1 ES 8503952A1 ES 529298 A ES529298 A ES 529298A ES 529298 A ES529298 A ES 529298A ES 8503952 A1 ES8503952 A1 ES 8503952A1
Authority
ES
Spain
Prior art keywords
group
cys
free
amino acid
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529298A
Other languages
English (en)
Other versions
ES529298A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A LERNER RICHARD
L BITTLE JAMES
Original Assignee
A LERNER RICHARD
L BITTLE JAMES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A LERNER RICHARD, L BITTLE JAMES filed Critical A LERNER RICHARD
Publication of ES529298A0 publication Critical patent/ES529298A0/es
Publication of ES8503952A1 publication Critical patent/ES8503952A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA VACUNA CONTRA PICORNAVIRUS.COMPRENDE: A) PROVEERSE DE UNA RESINA INSOLUBLE QUE CONTENGA UNA PLURALIDAD DE GRUPOS CLOROMETILO; B) ESTERIFICAR BOC-(MEOBZL)-CYS-OH EN LA RESINA; C) SEPARAR EL GRUPO BOC PARA FORMAR UN GRUPO AMINO LIBRE EN EL RESTO CYS; D) HACER REACCIONAR LA AMINA LIBRE CON UN EXCESO DE UN AMINOACIDO QUE CONTENGA, UN GRUPO CARBOXILO LIBRE, UN GRUPO AMINO UNIDO A UN GRUPO BOC Y UN GRUPO REACTIVO UNIDO A UN GRUPO PROTECTOR, PARA FORMAR UNA UNION AMIDO; E) SEPARAR EL EXCESO DEL AMINOACIDO Y EL GRUPO BOC, PARA FORMAR UN GRUPO AMINO LIBRE; F) REPETIR LAS ETAPAS (D), (E), PARA SINTETIZAR UN PEPTIDO PROTEGIDO QUE CONTENGA UNA SECUENCIA DE UNOS 20 RESTOS AMINOACIDOS EXCLUIDO EL CYS; G) HACER REACCIONAR UN EXCESO DE UN AMINOACIDO CYS PROTEGIDO ADICIONAL QUE TIENE UN GRUPO CARBOXILO LIBRE, CON EL GRUPO AMINO LIBRE, PARA FORMAR UNA UNION AMIDO CON EL Y PROPORCIONAR UN PEPTIDO PROTEGIDO CON UN RESTO CYS EN EL EXTREMO AMINO Y EN EL EXTREMO CARBOXI; H) SEPARAR EL PEPTIDO PROTEGIDO SINTETIZADO Y LOS GRUPOS PROTECTORES; I) OXIDAR AL PEPTIDO SINTETIZADO; Y J) DISOLVER UNA CANTIDAD DE PRODUCTO PEPTIDO OXIDADO EN UN DILUYENTE TOLERABLE, PARA FORMAR UNA VACUNA.
ES529298A 1982-04-14 1984-01-31 Un procedimiento para la preparacion de una vacuna contra picornavirus Expired ES8503952A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36830882A 1982-04-14 1982-04-14
US47884783A 1983-03-25 1983-03-25

Publications (2)

Publication Number Publication Date
ES529298A0 ES529298A0 (es) 1985-04-16
ES8503952A1 true ES8503952A1 (es) 1985-04-16

Family

ID=27004134

Family Applications (2)

Application Number Title Priority Date Filing Date
ES521411A Expired ES8501980A1 (es) 1982-04-14 1983-04-13 Un procedimiento para la preparacion de una vacuna contra picornavirus.
ES529298A Expired ES8503952A1 (es) 1982-04-14 1984-01-31 Un procedimiento para la preparacion de una vacuna contra picornavirus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES521411A Expired ES8501980A1 (es) 1982-04-14 1983-04-13 Un procedimiento para la preparacion de una vacuna contra picornavirus.

Country Status (8)

Country Link
EP (1) EP0105346B1 (es)
CA (1) CA1253298A (es)
DE (1) DE3382459D1 (es)
ES (2) ES8501980A1 (es)
FI (1) FI80601C (es)
IT (1) IT1197625B (es)
WO (1) WO1983003547A1 (es)
ZA (1) ZA832644B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA831854B (en) * 1982-03-26 1984-01-25 Biogen Nv Small peptides with the specificity of foot and mouth disease viral antigens
US5230888A (en) * 1982-05-06 1993-07-27 Massachusetts Institute Of Technology Production of neutralizing antibodies by polypeptide VP1 of enteroviruses and by oligopeptide fragments of polypeptide VP1
US4751083A (en) * 1982-05-06 1988-06-14 Massachusetts Institute Of Technology Production of neutralizing antibodies by polypeptide VP1 of enteroviruses and by oligopeptide fragments of polypeptide VP1
DE3378054D1 (en) * 1982-10-11 1988-10-27 Nat Res Dev Polypeptides useful in vaccination against enteroviruses
GB8301928D0 (en) * 1983-01-24 1983-02-23 Nicholson B H Process for producing polypeptides
AU573574B2 (en) * 1983-03-08 1988-06-16 Chiron Mimotopes Pty Ltd Immunogenic deteminants of foot and mouth disease virus
CA1247080A (en) * 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
WO1984003506A1 (en) * 1983-03-08 1984-09-13 Commw Serum Lab Commission Antigenically active amino acid sequences
EP0119153A3 (en) * 1983-03-11 1985-08-28 The Research Foundation Of State University Of New York Synthetic vaccines
FR2550094B1 (fr) * 1983-08-01 1986-03-21 Anvar Compositions de vaccins conditionnees pour la vaccination de sujets immunitairement non naifs contre un agent pathogene determine et contenant un haptene comportant lui-meme un site antigenique caracteristique dudit agent pathogene ou un oligomere de cet haptene
US4743553A (en) * 1984-07-18 1988-05-10 W. R. Grace & Co. Synthetic genes for bovine parainfluenza virus
GB8508685D0 (en) * 1985-04-03 1985-05-09 Minor P D Peptides
US4732971A (en) 1985-06-03 1988-03-22 Eli Lilly And Company Synthetic vaccines for foot and mouth disease
CN1054544C (zh) * 1993-10-21 2000-07-19 复旦大学 家畜口蹄疫病毒多肽疫苗及其制备方法
DE19638044A1 (de) * 1996-09-18 1998-03-19 Bayer Ag Immunogene Peptide von Maul- und Klauenseuchen-Viren
US6048538A (en) * 1997-10-03 2000-04-11 United Biomedical, Inc. Peptides derived from the non-structural proteins of foot and mouth disease virus as diagnostic reagents
US6107021A (en) * 1998-06-20 2000-08-22 United Biomedical, Inc. Synthetic peptide vaccines for foot-and-mouth disease
KR100531760B1 (ko) * 2003-04-28 2005-11-29 대한민국(관리부서 : 농림부 국립수의과학검역원) 구제역 바이러스의 감염여부를 진단하는 방법 및 이를구현하기 위한 진단키트
HUE051277T2 (hu) 2012-11-16 2021-03-01 United Biomedical Inc Szintetikus peptiden alapuló sürgõsségi vakcina ragadós száj- és körömfájás (FMD) ellen
CN109799344A (zh) * 2018-12-07 2019-05-24 中国农业科学院兰州兽医研究所 一种基于Asia I型口蹄疫病毒样颗粒的竞争ELISA抗体检测试剂盒

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140763A (en) * 1976-09-08 1979-02-20 The United States Of America As Represented By The Secretary Of Agriculture Vaccine for foot and mouth disease
GB2079288B (en) * 1980-05-12 1984-05-16 Biogen Nv Dna sequences recombinat dna molecules and processes for producing polypeptides with the specificity of foot and mouth disease viral antigens
IL63224A (en) * 1980-07-17 1985-05-31 Scripps Clinic Res Synthetic peptide specific antigenic determinant and method of manufacturing antigenic materials therefrom
GB2103622B (en) * 1981-06-16 1986-01-15 Genentech Inc Production of foot and mouth disease vaccine from microbially expressed antigens
ZA831854B (en) * 1982-03-26 1984-01-25 Biogen Nv Small peptides with the specificity of foot and mouth disease viral antigens
EP0107708B1 (en) * 1982-05-06 1987-10-28 Massachusetts Institute Of Technology Production of enterovirus neutralizing antibodies from vp1
EP0105481A1 (en) * 1982-09-30 1984-04-18 The Wellcome Foundation Limited Novel antigens and vaccines containing them
CA1230299A (fr) * 1982-11-30 1987-12-15 Marc Girard Peptides comportant un site immunogene du poliovirus et adns contenant des sequences nucleotidiques codant pour ces peptides
EP0268693B1 (en) * 1986-11-20 1989-10-18 Komori Printing Machinery Co., Ltd. Sheet conveyance table for sheet press

Also Published As

Publication number Publication date
ES529298A0 (es) 1985-04-16
ES521411A0 (es) 1984-12-16
FI834590A7 (fi) 1983-12-14
CA1253298A (en) 1989-04-25
EP0105346B1 (en) 1991-11-13
FI834590A0 (fi) 1983-12-14
WO1983003547A1 (en) 1983-10-27
FI80601B (fi) 1990-03-30
FI80601C (fi) 1990-07-10
ZA832644B (en) 1983-12-28
IT1197625B (it) 1988-12-06
EP0105346A4 (en) 1987-11-23
DE3382459D1 (de) 1991-12-19
EP0105346A1 (en) 1984-04-18
ES8501980A1 (es) 1984-12-16
IT8348094A0 (it) 1983-04-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401