ES8504166A1 - Un metodo de preparar derivados de 6,11-dihidrodibenz(b,e) oxepina. - Google Patents

Un metodo de preparar derivados de 6,11-dihidrodibenz(b,e) oxepina.

Info

Publication number
ES8504166A1
ES8504166A1 ES518414A ES518414A ES8504166A1 ES 8504166 A1 ES8504166 A1 ES 8504166A1 ES 518414 A ES518414 A ES 518414A ES 518414 A ES518414 A ES 518414A ES 8504166 A1 ES8504166 A1 ES 8504166A1
Authority
ES
Spain
Prior art keywords
dibenz
dihydro
oxo
same
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518414A
Other languages
English (en)
Other versions
ES518414A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES8504166A1 publication Critical patent/ES8504166A1/es
Publication of ES518414A0 publication Critical patent/ES518414A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 6,11-DIHIDRODIBENZB,EOXEPINA, DE FORMULA (I), EN LA QUE N VALE 0-2; Y R E Y PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA HR, EN LAS QUE HAL ES HALOGENO, R PUEDE SER VARIOS RADICALES Y N E Y TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE A UNA TEMPERATURA ENTRE 0JC Y 25JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIINFLAMATORIOS Y ANALGESICOS.
ES518414A 1981-12-23 1982-12-21 Un metodo de preparar derivados de 6,11-dihidrodibenz(b,e) oxepina. Granted ES518414A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/333,835 US4515946A (en) 1981-12-23 1981-12-23 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives

Publications (2)

Publication Number Publication Date
ES8504166A1 true ES8504166A1 (es) 1984-07-16
ES518414A0 ES518414A0 (es) 1984-07-16

Family

ID=23304461

Family Applications (2)

Application Number Title Priority Date Filing Date
ES518414A Granted ES518414A0 (es) 1981-12-23 1982-12-21 Un metodo de preparar derivados de 6,11-dihidrodibenz(b,e) oxepina.
ES531223A Granted ES531223A0 (es) 1981-12-23 1984-04-02 Un metodo de preparar derivados de 6,11-dihidrodibenz (b,e) oxepina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES531223A Granted ES531223A0 (es) 1981-12-23 1984-04-02 Un metodo de preparar derivados de 6,11-dihidrodibenz (b,e) oxepina

Country Status (4)

Country Link
US (1) US4515946A (es)
EP (1) EP0082521A1 (es)
JP (1) JPS58110580A (es)
ES (2) ES518414A0 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576960A (en) * 1981-12-23 1986-03-18 Hoechst Roussel Pharmaceuticals Incorporated 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives
US4515946A (en) * 1981-12-23 1985-05-07 Hoechst-Roussel Pharmaceuticals Inc. 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives
US4477465A (en) * 1983-03-10 1984-10-16 Hoechst-Roussel Pharmaceuticals Inc. Substituted 4,10-dihydro-10-oxothieno benzoxepins
US4526891A (en) * 1983-03-10 1985-07-02 Hoechst Roussel Pharmaceuticals Inc. Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins
US5840749A (en) * 1989-08-25 1998-11-24 Hoechst Marion Roussel, Inc. N-hydroxy-dibenz b,e!oxepinalkylamines, N-hydroxy-dibenz b,e!oxepinalkanoic acid amides and related heterocyclic analogues
WO2005007154A1 (ja) * 2003-07-16 2005-01-27 Kyowa Hakko Kogyo Co., Ltd. 疼痛の予防及び／または治療剤

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917631A (en) * 1971-11-09 1975-11-04 Bayer Ag Process for preparing substituted oxazolines
YU204274A (en) * 1973-07-24 1982-06-30 Hoechst Ag Process for preparing new dibenzoxepin derivatives
US4585788A (en) * 1973-09-06 1986-04-29 American Hoechst Corporation 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives
ES444144A1 (es) * 1975-01-14 1977-08-16 Hoechst Ag Un procedimiento para la preparacion de un acido 6,11-dihi- dro-11-oxo-dibenz (b, e) oxepin-alcanoico.
US4107322A (en) * 1976-06-03 1978-08-15 American Hoechst Corporation Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic acids
US4205170A (en) * 1976-12-03 1980-05-27 Nippon Chemiphar Company, Limited Propionic acid derivatives
US4118401A (en) * 1977-10-19 1978-10-03 American Hoechst Corporation Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor
JPS54122284A (en) * 1978-02-17 1979-09-21 Dainippon Pharmaceut Co Ltd Dibenzb,foxepin derivative
JPS54115388A (en) * 1978-03-01 1979-09-07 Nippon Chemiphar Co Ltd Acetic acid derivative and its preparation
US4282365A (en) * 1978-11-24 1981-08-04 Merck & Co., Inc. Dibenz[b,e]oxepin compounds
JPS55124777A (en) * 1979-03-20 1980-09-26 Toa Eiyou Kagaku Kogyo Kk Novel dibenzoxepin derivative and its preparation
EP0035475B1 (de) * 1980-03-05 1983-11-30 Ciba-Geigy Ag Herbizid wirkende 2-Nitro-5-phenoxyphenyl-oxazole, -oxazine, -imidazole, -pyrimidine und -thiazole, ihre Herstellung und Verwendung
JPS56156273A (en) * 1980-03-31 1981-12-02 Dainippon Pharmaceut Co Ltd Acetic derivative
US4515946A (en) * 1981-12-23 1985-05-07 Hoechst-Roussel Pharmaceuticals Inc. 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives

Also Published As

Publication number Publication date
ES8604731A1 (es) 1985-09-01
ES531223A0 (es) 1985-09-01
US4515946A (en) 1985-05-07
JPS58110580A (ja) 1983-07-01
EP0082521A1 (en) 1983-06-29
ES518414A0 (es) 1984-07-16

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