ES8504199A1 - Un procedimiento para la preparacion de nuevos analogos de mitomicina - Google Patents

Un procedimiento para la preparacion de nuevos analogos de mitomicina

Info

Publication number
ES8504199A1
ES8504199A1 ES529585A ES529585A ES8504199A1 ES 8504199 A1 ES8504199 A1 ES 8504199A1 ES 529585 A ES529585 A ES 529585A ES 529585 A ES529585 A ES 529585A ES 8504199 A1 ES8504199 A1 ES 8504199A1
Authority
ES
Spain
Prior art keywords
mitomycin
activity against
antitumor activity
experimental animal
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529585A
Other languages
English (en)
Other versions
ES529585A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES529585A0 publication Critical patent/ES529585A0/es
Publication of ES8504199A1 publication Critical patent/ES8504199A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ANALOGOS DE MITOMICINA, DE FORMULA (I), EN LA QUE A Y R PUEDEN SER VARIOS RADICALES; B ES AMINO; Y N VALE 0-3.CONSISTE EN LA REACCION DE IMTOMICINA C, DISUELTA EN DIMETILFORMAMIDA, CON 1 A 1,5 MOLES DE HIDRURO SODICO POR MOL DE MITOMICINA C; SEGUIDA DE LA REACCION DE LA FORMA ANIONICA DE LA MITOMICINA FORMADA CON UN REACTIVO ELECTROFILO CAPAZ DE FORMAR EL GRUPO AMIDINO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
ES529585A 1982-06-04 1984-02-09 Un procedimiento para la preparacion de nuevos analogos de mitomicina Expired ES8504199A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38514982A 1982-06-04 1982-06-04
US06/492,903 US4487769A (en) 1982-06-04 1983-05-09 Amidines

Publications (2)

Publication Number Publication Date
ES529585A0 ES529585A0 (es) 1985-04-16
ES8504199A1 true ES8504199A1 (es) 1985-04-16

Family

ID=27010906

Family Applications (3)

Application Number Title Priority Date Filing Date
ES522948A Expired ES8407493A1 (es) 1982-06-04 1983-06-03 Un procedimiento para la preparacion de nuevos analogos mitomicina.
ES529585A Expired ES8504199A1 (es) 1982-06-04 1984-02-09 Un procedimiento para la preparacion de nuevos analogos de mitomicina
ES529584A Granted ES529584A0 (es) 1982-06-04 1984-02-09 Un procedimiento para la preparacion de un 7-amino sustituido-9a-metoximitosano

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES522948A Expired ES8407493A1 (es) 1982-06-04 1983-06-03 Un procedimiento para la preparacion de nuevos analogos mitomicina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES529584A Granted ES529584A0 (es) 1982-06-04 1984-02-09 Un procedimiento para la preparacion de un 7-amino sustituido-9a-metoximitosano

Country Status (27)

Country Link
US (1) US4487769A (es)
KR (1) KR870000932B1 (es)
AR (1) AR241438A1 (es)
AT (1) AT394853B (es)
AU (1) AU571179B2 (es)
CA (1) CA1230333A (es)
CH (1) CH657856A5 (es)
DD (1) DD210275A5 (es)
DE (1) DE3319992A1 (es)
DK (2) DK161023C (es)
ES (3) ES8407493A1 (es)
FI (1) FI78700C (es)
FR (1) FR2528048B1 (es)
GB (1) GB2121796B (es)
GR (1) GR78277B (es)
HU (1) HU198936B (es)
IE (1) IE56107B1 (es)
IL (1) IL68852A0 (es)
IT (1) IT1206452B (es)
LU (1) LU84843A1 (es)
NL (1) NL8301949A (es)
NO (1) NO161676C (es)
NZ (1) NZ204352A (es)
OA (1) OA07452A (es)
PT (1) PT76810B (es)
SE (1) SE455504B (es)
YU (2) YU42866B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ206932A (en) * 1983-02-07 1987-08-31 University Patents Inc Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4579737A (en) * 1983-05-09 1986-04-01 Bristol-Myers Company Bis-amidines
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
JPS61176590A (ja) * 1985-01-31 1986-08-08 Kyowa Hakko Kogyo Co Ltd ７−ｎ−アミノメチレンマイトマイシン誘導体、製造法及び抗腫瘍剤
AT396688B (de) * 1985-02-21 1993-11-25 Bristol Myers Squibb Co Verfahren zur herstellung von kristallinem
US4639528A (en) * 1985-02-21 1987-01-27 Bristol-Myers Company Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane
ZA86308B (en) * 1985-02-25 1986-11-26 Bristol Myers Co In-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxy-mitosane
US4652644A (en) * 1985-04-29 1987-03-24 Bristol-Myers Company Process for preparation of N7 -amidino substituted mitomycin C derivatives
JPH066592B2 (ja) * 1986-04-18 1994-01-26 協和醗酵工業株式会社 マイトマイシン誘導体
US4791113A (en) * 1986-05-14 1988-12-13 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives as antileukemia agents
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
IL86665A0 (en) * 1987-06-12 1988-11-30 Bristol Myers Co Mitomycin analogs
IL89203A0 (en) * 1988-02-11 1989-09-10 Univ Houston 7-substituted hydrazine mitomycin analogs and pharmaceutical compositions containing them

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660578A (en) * 1957-04-06 1972-05-02 Kyowa Hakko Kogyo Kk Mitomycin c
US3121084A (en) * 1962-09-17 1964-02-11 Du Pont Selected n, n, n'-trisubstituted amidines and their preparation by reaction of compounds with-nh2 groups with amide acetals
NL129868C (es) * 1963-06-07
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3420846A (en) * 1964-08-25 1969-01-07 Kyowa Hakko Kogyo Kk 7-substituted mitomycin a
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
NZ206932A (en) * 1983-02-07 1987-08-31 University Patents Inc Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
JPS6073085A (ja) * 1983-09-28 1985-04-25 Matsushita Refrig Co ロ−タリ−コンプレツサ
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes

Also Published As

Publication number Publication date
DE3319992C2 (es) 1991-11-21
HU198936B (en) 1989-12-28
GB8315205D0 (en) 1983-07-06
YU43427B (en) 1989-06-30
SE8303160L (sv) 1984-01-27
CA1230333A (en) 1987-12-15
DK253083A (da) 1983-12-05
FI78700C (fi) 1989-09-11
FI831972L (fi) 1983-12-05
SE455504B (sv) 1988-07-18
FR2528048B1 (fr) 1986-12-12
ES522948A0 (es) 1984-10-01
FI78700B (fi) 1989-05-31
DK253083D0 (da) 1983-06-03
YU42866B (en) 1988-12-31
DE3319992A1 (de) 1983-12-08
KR840005143A (ko) 1984-11-03
PT76810B (en) 1986-04-09
PT76810A (en) 1983-07-01
DK281490A (da) 1990-11-27
DD210275A5 (de) 1984-06-06
NO161676C (no) 1989-09-13
IE831320L (en) 1983-12-04
GB2121796A (en) 1984-01-04
GB2121796B (en) 1986-03-12
FI831972A0 (fi) 1983-06-01
NO161676B (no) 1989-06-05
NL8301949A (nl) 1984-01-02
DK281490D0 (da) 1990-11-27
YU16486A (en) 1986-12-31
AU571179B2 (en) 1988-04-14
CH657856A5 (de) 1986-09-30
YU124183A (en) 1986-06-30
LU84843A1 (fr) 1984-03-07
ES8504198A1 (es) 1985-04-16
ES8407493A1 (es) 1984-10-01
ES529585A0 (es) 1985-04-16
NZ204352A (en) 1987-07-31
DK161023B (da) 1991-05-21
NO832022L (no) 1983-12-05
DK162167B (da) 1991-09-23
KR870000932B1 (ko) 1987-05-11
SE8303160D0 (sv) 1983-06-03
DK161023C (da) 1991-10-28
AU1501483A (en) 1983-12-08
ATA206483A (de) 1991-12-15
AR241438A1 (es) 1992-07-31
FR2528048A1 (fr) 1983-12-09
IL68852A0 (en) 1983-10-31
DK162167C (da) 1992-02-24
ES529584A0 (es) 1985-04-16
US4487769A (en) 1984-12-11
OA07452A (fr) 1984-03-31
GR78277B (es) 1984-09-26
IE56107B1 (en) 1991-04-24
AT394853B (de) 1992-07-10
IT1206452B (it) 1989-04-27
IT8321461A0 (it) 1983-06-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041004