ES8504821A1 - Un metodo de producir derivados de cefalosporina - Google Patents

Un metodo de producir derivados de cefalosporina

Info

Publication number
ES8504821A1
ES8504821A1 ES526561A ES526561A ES8504821A1 ES 8504821 A1 ES8504821 A1 ES 8504821A1 ES 526561 A ES526561 A ES 526561A ES 526561 A ES526561 A ES 526561A ES 8504821 A1 ES8504821 A1 ES 8504821A1
Authority
ES
Spain
Prior art keywords
group
substituted
optionally
cephalosporin derivatives
prophylactic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526561A
Other languages
English (en)
Other versions
ES526561A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Publication of ES8504821A1 publication Critical patent/ES8504821A1/es
Publication of ES526561A0 publication Critical patent/ES526561A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60J—WINDOWS, WINDSCREENS, NON-FIXED ROOFS, DOORS, OR SIMILAR DEVICES FOR VEHICLES; REMOVABLE EXTERNAL PROTECTIVE COVERINGS SPECIALLY ADAPTED FOR VEHICLES
    • B60J10/00—Sealing arrangements
    • B60J10/20—Sealing arrangements characterised by the shape
    • B60J10/24—Sealing arrangements characterised by the shape having tubular parts
    • B60J10/248—Sealing arrangements characterised by the shape having tubular parts having two or more tubular cavities, e.g. formed by partition walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60J—WINDOWS, WINDSCREENS, NON-FIXED ROOFS, DOORS, OR SIMILAR DEVICES FOR VEHICLES; REMOVABLE EXTERNAL PROTECTIVE COVERINGS SPECIALLY ADAPTED FOR VEHICLES
    • B60J10/00—Sealing arrangements
    • B60J10/80—Sealing arrangements specially adapted for opening panels, e.g. doors
    • B60J10/86—Sealing arrangements specially adapted for opening panels, e.g. doors arranged on the opening panel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Removal Of Floating Material (AREA)
  • Measurement Of Force In General (AREA)
  • Train Traffic Observation, Control, And Security (AREA)

Abstract

METODO DE PRODUCIR DERIVADOS DE CEFALOSPORINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER DERIVADOS DE CEFALOSPORINA DE FORMULA (I), DONDE R ES UN RESIDUO BAB-, BBB- O BGB-AMINOACIDO; R ES UN GRUPO 1-ALCANOILOXIALQUILO Y OTROS; R ES CARBAMOILOXIMETILO O UN GRUPO HETEROCICLOTIOMETILO; Y R ES H O UN GRUPO HIDROXI. LA REACCION SE REALIZA ENTRE C20 Y 0JC DE TEMPERATYRA Y EN PRESENCIA DE UN DISOLVENTE INERTE TAL COMO AGUA, ACETONA Y OTROS.TIENE APLICACION FARMACEUTICA POR SU ALTA ACTIVIDAD ANTIBACTERIANA.
ES526561A 1982-11-10 1983-10-19 Un metodo de producir derivados de cefalosporina Granted ES526561A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1982/000437 WO1984001949A1 (fr) 1982-11-10 1982-11-10 Derives de cephalosporine, leur procede de preparation et agent prophylactique de traitement contre les infections bacteriennes

Publications (2)

Publication Number Publication Date
ES8504821A1 true ES8504821A1 (es) 1985-04-16
ES526561A0 ES526561A0 (es) 1985-04-16

Family

ID=13762361

Family Applications (3)

Application Number Title Priority Date Filing Date
ES526561A Granted ES526561A0 (es) 1982-11-10 1983-10-19 Un metodo de producir derivados de cefalosporina
ES532997A Granted ES532997A0 (es) 1982-11-10 1984-05-31 Un metodo de producir derivados de cefalosporina
ES532996A Expired ES8507150A1 (es) 1982-11-10 1984-05-31 Un metodo de producir derivados de cefalosporina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES532997A Granted ES532997A0 (es) 1982-11-10 1984-05-31 Un metodo de producir derivados de cefalosporina
ES532996A Expired ES8507150A1 (es) 1982-11-10 1984-05-31 Un metodo de producir derivados de cefalosporina

Country Status (18)

Country Link
US (1) US4605651A (es)
EP (1) EP0108942B1 (es)
JP (1) JPS59116292A (es)
KR (1) KR900007200B1 (es)
AT (1) ATE32724T1 (es)
AU (1) AU568094B2 (es)
CA (1) CA1239928A (es)
CY (1) CY1512A (es)
DE (1) DE3375787D1 (es)
DK (1) DK481883A (es)
ES (3) ES526561A0 (es)
FI (1) FI75348C (es)
HK (1) HK39390A (es)
NO (1) NO162240C (es)
NZ (1) NZ206019A (es)
SU (2) SU1309912A3 (es)
WO (1) WO1984001949A1 (es)
ZA (1) ZA837635B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034975A (ja) * 1984-03-29 1985-02-22 Kyoto Yakuhin Kogyo Kk セフアロスポリンの製造方法
JPS6034978A (ja) * 1984-03-29 1985-02-22 Kyoto Yakuhin Kogyo Kk セフアロスポリン誘導体およびその製造方法
DK401088A (da) * 1987-07-21 1989-01-22 Kyoto Pharma Ind Cephalosporinforbindelse, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende den
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
JP4323968B2 (ja) * 2004-01-14 2009-09-02 株式会社日立コミュニケーションテクノロジー 無線通信装置のタイミング調整方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1229453A (es) * 1968-01-30 1971-04-21
US3701775A (en) * 1970-11-25 1972-10-31 Smith Kline French Lab Esters of mandeloylaminocephalosporanic acids
IL38099A (en) * 1970-12-17 1976-01-30 Smith Kline French Lab 3-heterocyclyl thiomethylcephalosporins
US3812116A (en) * 1971-07-02 1974-05-21 Fujisawa Pharmaceutical Co 7-acylated 3-substituted cephalosporin compounds
GB1425933A (en) * 1972-03-13 1976-02-25 Astra Laekemedel Ab Cephalosporins
US4092476A (en) * 1974-02-21 1978-05-30 Beecham Group Limited Phthalidyl esters of 7-[(α amino, 2 substituted acetamido)-3-(heterocyclic-thio methyl)]cephalosporins
GB1492393A (en) * 1974-02-21 1977-11-16 Beecham Group Ltd Cephalosporin esters
CH606001A5 (es) * 1974-05-13 1978-10-13 Ciba Geigy Ag
US3933808A (en) * 1974-05-20 1976-01-20 Eli Lilly And Company Cephalosporin esters
US4172196A (en) * 1974-09-03 1979-10-23 Bristol-Myers Company Certain 7-α-substituted-α-hydroxyacetamido-3-(1-carboxymethyltetrazol-5-yl-thiomethyl)-3-cephem-4-carboxylic acids
JPS5283877A (en) * 1976-01-01 1977-07-13 Lilly Co Eli Cephalospoline esters
MA18686A1 (fr) * 1978-07-07 1980-10-01 Ciba Geigy Ag Composes aminothiazoliques
JPS57193489A (en) * 1981-05-21 1982-11-27 Fujisawa Pharmaceut Co Ltd Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation

Also Published As

Publication number Publication date
DE3375787D1 (en) 1988-04-07
US4605651A (en) 1986-08-12
ES532996A0 (es) 1985-08-16
FI833839A7 (fi) 1984-05-11
FI75348C (fi) 1988-06-09
FI833839A0 (fi) 1983-10-20
KR840006667A (ko) 1984-12-01
CY1512A (en) 1990-08-03
NZ206019A (en) 1986-06-11
EP0108942B1 (en) 1988-03-02
KR900007200B1 (ko) 1990-10-05
SU1309912A3 (ru) 1987-05-07
FI75348B (fi) 1988-02-29
HK39390A (en) 1990-06-01
SU1322983A3 (ru) 1987-07-07
DK481883A (da) 1984-05-11
NO833807L (no) 1984-05-11
ES8507151A1 (es) 1985-08-16
ES526561A0 (es) 1985-04-16
EP0108942A2 (en) 1984-05-23
CA1239928A (en) 1988-08-02
AU2019983A (en) 1984-05-17
JPS59116292A (ja) 1984-07-05
ZA837635B (en) 1984-11-28
EP0108942A3 (en) 1985-05-15
NO162240B (no) 1989-08-21
ES8507150A1 (es) 1985-08-16
ATE32724T1 (de) 1988-03-15
WO1984001949A1 (fr) 1984-05-24
ES532997A0 (es) 1985-08-16
NO162240C (no) 1989-11-29
AU568094B2 (en) 1987-12-17
DK481883D0 (da) 1983-10-20

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