ES8506031A1 - Un procedimiento para la preparacion de derivados de ergolina - Google Patents

Un procedimiento para la preparacion de derivados de ergolina

Info

Publication number
ES8506031A1
ES8506031A1 ES531906A ES531906A ES8506031A1 ES 8506031 A1 ES8506031 A1 ES 8506031A1 ES 531906 A ES531906 A ES 531906A ES 531906 A ES531906 A ES 531906A ES 8506031 A1 ES8506031 A1 ES 8506031A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
compound
formula
ergoline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531906A
Other languages
English (en)
Other versions
ES531906A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838311679A external-priority patent/GB8311679D0/en
Priority claimed from GB838314816A external-priority patent/GB8314816D0/en
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES531906A0 publication Critical patent/ES531906A0/es
Publication of ES8506031A1 publication Critical patent/ES8506031A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ERGOLINA.CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (XFCFNFR5), EN UN DISOLVENTE COMO AGUA, ETANOL, ACIDO ACETICO Y A UNA TEMPERATURA ENTRE 50J Y 100JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO; R1, H O METILO; R2, H, HAL, METILO U OTROS; R3 H O METOXI; R4 GRUPO HIDROCARBILO DE C 1 A 4; R5 H O UN GRUPO HIDROCARBILO DE C 1 A 4; R6, H O ALQUILO DE C 1 A 4; R7, R8 Y R9, H; A, -CHR6, CH2-CHR6 Y OTROS; B, CIANO (ALCOXI C 2 A 5) CARBONILO Y OTROS; X, O, S O IMINO Y N 0, 1 O 2.SE UTILIZAN COMO ANTIPROLACTINICOS Y ANTIHIPERTENSIVOS.
ES531906A 1983-04-28 1984-04-25 Un procedimiento para la preparacion de derivados de ergolina Expired ES8506031A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838311679A GB8311679D0 (en) 1983-04-28 1983-04-28 Ergoline derivatives
GB838314816A GB8314816D0 (en) 1983-05-27 1983-05-27 Ergoline derivatives

Publications (2)

Publication Number Publication Date
ES531906A0 ES531906A0 (es) 1985-06-01
ES8506031A1 true ES8506031A1 (es) 1985-06-01

Family

ID=26285978

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531906A Expired ES8506031A1 (es) 1983-04-28 1984-04-25 Un procedimiento para la preparacion de derivados de ergolina

Country Status (18)

Country Link
US (1) US4690929A (es)
EP (1) EP0126968B1 (es)
KR (1) KR900008696B1 (es)
AU (1) AU556968B2 (es)
CA (1) CA1205801A (es)
DE (1) DE3475709D1 (es)
DK (1) DK162996C (es)
ES (1) ES8506031A1 (es)
FI (1) FI81349C (es)
GR (1) GR79575B (es)
HU (1) HU198713B (es)
IE (1) IE57240B1 (es)
IL (1) IL71633A (es)
NO (1) NO161562C (es)
PH (1) PH21123A (es)
PT (1) PT78496B (es)
SU (1) SU1327788A3 (es)
YU (1) YU43357B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714767D0 (en) * 1987-06-24 1987-07-29 Erba Farmitalia Egoline derivatives
HU196399B (en) * 1983-02-16 1988-11-28 Sandoz Ag Process for producing ergoline derivatives and pharmaceutical compositions comprising such compounds
GB8501078D0 (en) * 1985-01-16 1985-02-20 Erba Farmitalia Piperazin-1-yl-ergo-line derivatives
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
GB8515528D0 (en) * 1985-06-19 1985-07-24 Erba Farmitalia Ergoline derivatives
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
DE3528576A1 (de) * 1985-08-06 1987-02-19 Schering Ag Verfahren zur herstellung von ergolin-thioharnstoffen
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
GB8617907D0 (en) * 1986-07-22 1986-08-28 Erba Farmitalia Tetracyclic indole derivatives
GB8702364D0 (en) * 1987-02-03 1987-03-11 Erba Farmitalia Ergolinyl heterocycles
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
AU644625B2 (en) * 1990-01-25 1993-12-16 Farmitalia Carlo Erba S.R.L. Process for preparing ergoline derivatives
GB9006772D0 (en) * 1990-03-27 1990-05-23 Erba Carlo Spa 4-piperidinyl-ergoline derivatives
DK0628042T3 (da) * 1992-12-24 2001-11-12 Pharmacia & Upjohn Spa Serotoninerge ergolinderivater
JP3996897B2 (ja) 2001-06-08 2007-10-24 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス ソマトスタチン−ドーパミンキメラ類似体
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
CN104768565B (zh) 2012-11-01 2017-04-26 益普生制药股份有限公司 促生长素抑制素类似物及其二聚体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL283102A (es) * 1961-09-11
DK140596B (da) * 1971-05-19 1979-10-08 Sandoz Ag Analogifremgangsmåde til fremstilling af 8beta-(ureidomethyl)-ergolenderivater.
NL7416120A (nl) * 1973-12-21 1975-06-24 Farmaceutici Italia Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten.
US3996228A (en) * 1973-12-21 1976-12-07 Societa' Farmaceutici Italia S.P.A. Pyrimidinoaminoethyl ergoline derivatives
DE2456930A1 (de) * 1974-12-02 1976-08-12 Tesch Kg E Elektronisches zeitspeicherrelais
CH615181A5 (en) * 1975-05-21 1980-01-15 Sandoz Ag Process for the preparation of novel ergolene derivatives
GB2056437A (en) * 1979-08-07 1981-03-18 Erba Farmitalia Secoergoline derivatives
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen
DD154897A1 (de) * 1980-12-02 1982-04-28 Seifert Karlheinz Dipl Chem Dr Verfahren zur herstellung von 8-substituierten ergolinen
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
GB2112382B (en) * 1981-11-06 1985-03-06 Erba Farmitalia Ergoline derivatives

Also Published As

Publication number Publication date
YU74284A (en) 1986-10-31
EP0126968B1 (en) 1988-12-21
FI841631A0 (es) 1984-04-25
CA1205801A (en) 1986-06-10
IE57240B1 (en) 1992-06-17
HUT34024A (en) 1985-01-28
IL71633A (en) 1987-12-20
NO161562C (no) 1989-08-30
NO161562B (no) 1989-05-22
DE3475709D1 (en) 1989-01-26
KR900008696B1 (ko) 1990-11-27
NO841657L (no) 1984-10-29
AU556968B2 (en) 1986-11-27
KR840008353A (ko) 1984-12-14
GR79575B (es) 1984-10-30
ES531906A0 (es) 1985-06-01
FI81349B (fi) 1990-06-29
EP0126968A1 (en) 1984-12-05
DK162996B (da) 1992-01-06
DK212784D0 (da) 1984-04-27
DK212784A (da) 1984-10-29
DK162996C (da) 1992-06-01
FI841631A7 (es) 1984-10-29
IL71633A0 (en) 1984-07-31
PT78496A (en) 1984-05-01
FI81349C (fi) 1990-10-10
PH21123A (en) 1987-07-27
YU43357B (en) 1989-06-30
HU198713B (en) 1989-11-28
PT78496B (en) 1986-07-22
AU2742184A (en) 1984-11-01
SU1327788A3 (ru) 1987-07-30
US4690929A (en) 1987-09-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202