ES8506033A1 - Procedimiento de obtencion de vincristina y de sus sales de adicion - Google Patents
Procedimiento de obtencion de vincristina y de sus sales de adicionInfo
- Publication number
- ES8506033A1 ES8506033A1 ES529562A ES529562A ES8506033A1 ES 8506033 A1 ES8506033 A1 ES 8506033A1 ES 529562 A ES529562 A ES 529562A ES 529562 A ES529562 A ES 529562A ES 8506033 A1 ES8506033 A1 ES 8506033A1
- Authority
- ES
- Spain
- Prior art keywords
- vincristine
- preparation
- vinblastine
- degrees
- permanganate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229960004528 vincristine Drugs 0.000 title abstract 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title abstract 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 229960003048 vinblastine Drugs 0.000 abstract 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 2
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229920000570 polyether Polymers 0.000 abstract 1
- 239000012286 potassium permanganate Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE VINCRISTINA Y DE SUS SALES DE ADICION.CONSISTE EN OBTENER VINCRISTINA A PARTIR DE LA VINBLASTINA, PARA LO CUAL HAY QUE TRATAR ESTA ULTIMA CON ION PERMANGANATO EN MEDIO ACIDO COMO ACIDO ACETICO, EN TOLUENO O EN UN SOLVENTE ORGANICO CLORADO COMO DICLOROMETANO, MANTENIENDOSE EL MEDIO DE REACCION A UNA TEMPERATURA ENTRE C40 Y C75JC Y AISLAR EL PRODUCTO OBTENIDO DE MANERA CLASICA, EN DONDE ANTES DE AISLAR LA VINCRISTINA, HAY QUE EXTRAER CON DICLOROMETANO EL MEDIO DE REACCION ACUOSO RESULTANTE DE LA ADICION DE SOLUCION DE BISULFITO CON EL QUE PREVIAMENTE SE HABRA TRATADO LA VINBLASTINA DESPUES DE HABERLO HECHO CON ION PERMANGANATO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU84640A LU84640A1 (fr) | 1983-02-10 | 1983-02-10 | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES529562A0 ES529562A0 (es) | 1985-07-01 |
| ES8506033A1 true ES8506033A1 (es) | 1985-07-01 |
Family
ID=19730034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529562A Expired ES8506033A1 (es) | 1983-02-10 | 1984-02-08 | Procedimiento de obtencion de vincristina y de sus sales de adicion |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0117861B1 (es) |
| JP (1) | JPS59152390A (es) |
| AT (1) | ATE31311T1 (es) |
| DE (1) | DE3468028D1 (es) |
| ES (1) | ES8506033A1 (es) |
| HU (1) | HU189817B (es) |
| IL (1) | IL70998A (es) |
| LU (1) | LU84640A1 (es) |
| ZA (1) | ZA84963B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2582651B1 (fr) * | 1985-06-03 | 1987-08-28 | Pf Medicament | Procede de preparation de vincristine |
| FR2651348B1 (es) * | 1989-08-04 | 1993-01-22 | Adir | |
| CN101362771B (zh) * | 2008-09-26 | 2010-12-08 | 深圳万乐药业有限公司 | 高纯度硫酸长春新碱的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
| US4303584A (en) * | 1980-04-02 | 1981-12-01 | Eli Lilly And Company | Method of preparing vincristine |
| HU183385B (en) * | 1980-04-02 | 1984-04-28 | Lilly Co Eli | Process for preparing vinca dimer derivatives |
-
1983
- 1983-02-10 LU LU84640A patent/LU84640A1/fr unknown
-
1984
- 1984-02-08 ES ES529562A patent/ES8506033A1/es not_active Expired
- 1984-02-09 JP JP59022703A patent/JPS59152390A/ja active Granted
- 1984-02-09 HU HU84526A patent/HU189817B/hu not_active IP Right Cessation
- 1984-02-09 AT AT84870018T patent/ATE31311T1/de not_active IP Right Cessation
- 1984-02-09 DE DE8484870018T patent/DE3468028D1/de not_active Expired
- 1984-02-09 ZA ZA84963A patent/ZA84963B/xx unknown
- 1984-02-09 EP EP84870018A patent/EP0117861B1/fr not_active Expired
- 1984-02-17 IL IL70998A patent/IL70998A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| LU84640A1 (fr) | 1984-11-08 |
| IL70998A (en) | 1986-12-31 |
| ATE31311T1 (de) | 1987-12-15 |
| ZA84963B (en) | 1984-09-26 |
| ES529562A0 (es) | 1985-07-01 |
| EP0117861A1 (fr) | 1984-09-05 |
| JPH041758B2 (es) | 1992-01-14 |
| EP0117861B1 (fr) | 1987-12-09 |
| HU189817B (en) | 1986-08-28 |
| DE3468028D1 (en) | 1988-01-21 |
| JPS59152390A (ja) | 1984-08-31 |
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